Whitening Effect of Salicylic Acid Peels in Asian Patients

Ahn, Hyo Hyun; Kim, Il Hwan

doi:10.1111/j.1524-4725.2006.32075.x

Cited by 51 publications

(31 citation statements)

References 9 publications

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“…Salicylic acid is antiinflammatory and thus serves to decrease existing post-acne hyperpigmentation and prevent further inflammation. In addition, Ahn and Kim 18 showed salicylic acid to have a whitening effect on the skin. This effect was seen in the present study too, with patients reporting diffuse lightening of their facial complexion.…”

Section: Discussionmentioning

confidence: 99%

Glycolic Acid Peels Versus Salicylic-Mandelic Acid Peels in Active Acne Vulgaris and Post-Acne Scarring and Hyperpigmentation: A Comparative Study

Garg¹,

Sinha²,

Sarkar³

2009

Dermatologic Surgery

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Section: Discussionmentioning

confidence: 99%

Glycolic Acid Peels Versus Salicylic-Mandelic Acid Peels in Active Acne Vulgaris and Post-Acne Scarring and Hyperpigmentation: A Comparative Study

Garg¹,

Sinha²,

Sarkar³

2009

Dermatologic Surgery

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“…Previous publications have suggested that post-inflammatory hyperpigmentation is improved by use of anti-inflammatory and depigmenting agents,7,12,14,16–19,31 but few have objectively evaluated post-inflammatory hyperpigmentation at the histological level 14. Our results indicate that both drugs are capable of reducing mononuclear and phagocytic cell infiltrates and repairing the fragmented epidermal basal membrane, thus reducing melanin expression.…”

Section: Discussionmentioning

confidence: 51%

“…Prevention and treatment of the underlying inflammatory condition are the first steps, followed by depigmenting interventions. Topical treatments used in post-inflammatory hyperpigmentation include hydroquinone (alone or in combination with other agents),12,13 mequinol,7,8 retinoids,14–16 azelaic acid,17 chemical peels,18,19 and light-based procedures 20. There are other topical treatments known for their depigmenting properties, including kojic acid, arbutin, niacinamide, and N-acetyl glucosamine, but none of these have been studied in post-inflammatory hyperpigmentation 7…”

Section: Introductionmentioning

confidence: 99%

Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study

Castanedo-Cázares¹,

Lárraga-Piñones²,

Ehnis-Pérez³

et al. 2013

CCID

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BackgroundAxillary hyperpigmentation is a frequent cause of cosmetic consultations in dark-skinned women from tropical areas, including Latin America. Currently, there is no widely accepted treatment for the disorder, but it is usually treated with bleaching agents because it is considered a variant of inflammatory hyperpigmentation. The purpose of this study was to assess the efficacy of niacinamide 4% and desonide 0.05% emulsions compared with placebo in the treatment of axillary hyperpigmentation.MethodsTwenty-four women aged 19–27 years with hyperpigmented axillae (phototype III–V) were randomly assigned to receive the study treatments in the axillary region. Improvement was assessed at baseline, then clinically and by colorimetry 9 weeks later. Quantitative evaluation including melanin, inflammatory infiltrates, NKI/Beteb, CD1a, CD68, and collagen type IV content was performed by histochemistry and immunohistochemistry, assisted by computerized morphometric analysis.ResultsBoth niacinamide and desonide induced significant colorimetric improvement compared with placebo; however, desonide showed a better depigmenting effect than niacinamide. A good to excellent response was achieved in 24% of cases for niacinamide, 30% for desonide, and 6% for placebo. We observed a marked disruption of the basal membrane in axillary hyperpigmentation and an inflammatory infiltrate that improved after treatment. Decreased pigmentation in the desonide-treated axillae was associated with recovery of disruption at the basal membrane.ConclusionNiacinamide and desonide showed depigmenting properties in women with axillary hyperpigmentation. These findings may be explained by their antimelanogenic and anti-inflammatory properties, respectively.

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“…A clinical study was conducted using salicylic acid peels in 24 Korean patients with PIH secondary to acne [36]. Salicylic acid (30%) peels were performed every 2 weeks for 3 months.…”

Section: Chemical Peelsmentioning

confidence: 99%

Review of Topical Lightening Agents

Dharmana¹

2014

Pigmentary Disorders

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Whitening Effect of Salicylic Acid Peels in Asian Patients

Abstract: Salicylic acid peels are beneficial in whitening the face of Asian patients with acne. The whitening effect would be an important factor in choosing the superficial peeling agent for them.

Cited by 51 publications

References 9 publications

Glycolic Acid Peels Versus Salicylic-Mandelic Acid Peels in Active Acne Vulgaris and Post-Acne Scarring and Hyperpigmentation: A Comparative Study

Glycolic Acid Peels Versus Salicylic-Mandelic Acid Peels in Active Acne Vulgaris and Post-Acne Scarring and Hyperpigmentation: A Comparative Study

Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study

Review of Topical Lightening Agents

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