Whitening Agent : Mekanisme, Sumber dari Alam dan Teknologi Formulasinya

Soyata, Amelia; Chaerunisaa, Anis Yohana

doi:10.24198/mfarmasetika.v6i2.28139

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…Hydroquinone (HQ) is an agent that widely known as a skin whitening and hyperpigmentation inhibitor [8]. However, there are side effects that appear such as irritation, erythema, ochronotic, rash, pruritic, burning sensation and to be mutagenic [9].…”

Section: Introductionmentioning

confidence: 99%

In silico analysis of trisindoline 1 as tyrosinase inhibitors

Sukma,

Nurhayati,

Santoso

2023

IOP Conf. Ser.: Earth Environ. Sci.

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Hyperpigmentation is darkening condition in the skin area due to excessive melanin production. This condition interferes with skin aesthetics and can increase the production of reactive oxygen species which can cause skin damage. The widely targeted approach to treat hyperpigmentation is inhibition of tyrosinase. Trisindoline is a compound synthesized from the marine sponge Hyrtios altum and has high bioactivity potential. Trisindoline itself has been shown in vitro to inhibit tyrosinase. Thus, trisindoline was synthesized into four derivatives, one of which was trisindoline 1 with the addition of a nitro group. This paper aims to determine the potency of trisindoline 1 as tyrosinase inhibitors and then compared with commercial tyrosinase inhibitors, kojic acid and arbutin, in silico. In silico analysis was carried out by molecular docking of trisindoline 1 to tyrosinase using AutoDock Vina. Kojic acid was used as the native ligand and arbutin as the control ligand. Visualization of molecular docking results using BIOVIA Discovery Studio. The binding affinity score obtained indicates that trisindoline 1 has the lowest binding score. It is -9.2 kcal/mol to the tyrosinase enzyme. These results indicate that trisindoline 1 has the potential as a candidate for anti-hyperpigmentation agents through the mechanism of tyrosinase inhibitors.

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Section: Introductionmentioning

confidence: 99%

In silico analysis of trisindoline 1 as tyrosinase inhibitors

Sukma,

Nurhayati,

Santoso

2023

IOP Conf. Ser.: Earth Environ. Sci.

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The effect of different salt concentrations on the physical properties of preparations gel face scrub gracilaria sp.

Mutiara,

Alamsjah,

Saputra

2024

IOP Conf. Ser.: Earth Environ. Sci.

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Human skin is often exposed to sunlight and pollution so it looks dull and lacks shine. This causes a buildup of dead skin cells so it is necessary to exfoliate using a Scrub. The Scrub material that can be used is salt. The purpose of this study was to determine the effect of adding salt concentration on the physical properties of the face Scrub gel preparation Gracilaria sp. The method used in this study was a completely randomized design (CRD) experiment with four treatments and five replications. The treatment used was administration with different salt concentrations, namely P0 (0%), P1 (10%), P2 (20%) and P3 (30%). The main parameters observed were the physical properties of the facial Scrub gel preparation which included pH test, homogeneity test, viscosity test, organoleptic test, specific gravity test. While the supporting parameters are irritation test and SEM-EDX test. The results showed that the administration of different salt concentrations had a significant effect on the physical properties of the facial Scrub gel preparation. The best formulation was in the P2 treatment (20% salt).

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Whitening Agent : Mekanisme, Sumber dari Alam dan Teknologi Formulasinya

Cited by 2 publications

References 48 publications

In silico analysis of trisindoline 1 as tyrosinase inhibitors

In silico analysis of trisindoline 1 as tyrosinase inhibitors

The effect of different salt concentrations on the physical properties of preparations gel face scrub gracilaria sp.

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