White tea (Camellia sinensis) inhibits proliferation of the colon cancer cell line, HT-29, activates caspases and protects DNA of normal cells against oxidative damage

Abstract

Tea (Camellia sinensis) is one of the most consumed beverages in the world. White tea is made from the buds and young leaves of the tea plant which are steamed and dried, whilst undergoing minimal oxidation. The MTT assay was used to test the extract on the effect of the proliferation of the colorectal cancer cell line, HT-29. The extract inhibited the proliferation of HT-29 cells with an IC50 of 87μg/ml. The extract increased the levels of caspase-3, -8, and -9 activity in the cells. DNA damage in 3T3-L1 normal cells was detected by using the comet assay. The extract protected 3T3-L1 cells against H2O2-induced DNA damage. The results from this study show that white tea has antioxidant and antiproliferative effects against cancer cells, but protect normal cells against DNA damage. Regular intake of white tea can help to maintain good health and protect the body against disease.

Cytotoxic activity and apoptotic induction of some edible Thai local plant extracts against colon and liver cancer cell lines

“…Hajiaghaalipour et al [2] found that Camellia sinensis extract exhibited anti-proliferative effects on HT-29 cells. Devika and Mohandas [3] reported that extracts of Foeniculum vulgare induced apoptosis in cervical cancer cells and had anti-proliferative effects through DNA fragmentation.…”

Cytotoxic Effect of Caralluma fimbriata Against Human Colon Cancer Cells

“…Naturaceuticals such as silibinin, quercetin, curcumin [13][14][15] and plant extracts such as Curcuma longa, Moringa oleifera, Camellia sinensis, Dictyopteris undulata have also been tested for their anticancer effects against colon cancer. [16][17][18][19] In previous studies C. fimbriata has been evaluated against several cancer models except colon cancer. Methanolic extract of the C. fimbriata reported to exhibit anti lung cancer activity, Priya et al carried out cell viability and growth inhibition activity of the methanolic extract of C. fimbriata against A-549 lung cancer cell lines.…”

Effect of water quality on the main components in Fuding white tea infusions

“…White tea is unfermented and prepared exclusively from young tea leaves and buds that have tiny, silvery hairs (Kim et al 2015;Nunes et al 2015;Rusak et al 2008;Hajiaghaalipour et al 2015) that differ from other teas (Zielinski et al 2016). During growth, buds may be shielded from sunlight in order to reduce the chlorophyll content, which makes the leaves appear white (Kim et al 2015).…”