Cytotoxic activity and apoptotic induction of some edible Thai local plant extracts against colon and liver cancer cell lines

Putthawan, Pornhathai; Poeaim, Supattra; Areekul, Varipat

doi:10.4314/tjpr.v16i12.17

Cited by 9 publications

(7 citation statements)

References 17 publications

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“…(Gama -Sitosterol, 2019). This strengthened with the statement that F. Auriculata displayed more potent anti-proliferative activity than chemotherapy medicine (Ghani et al, 2019), (Putthawan,Poaeman, 2017), (Shao, 2014). Besides it also contain an…”

Section: Resultssupporting

confidence: 57%

Aristolone content analysis in ficus auriculata as predicted apoptotic activity in hela cells

Ambarwati

Jannah

Adawiyah

2021

J. Heal. Technol. Assess. Midwifery

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Antioxidants and herbs have been scientifically proven to be one of the substances that can prevent cervical cancer. The incidence of cervical cancer in Indonesia is very high and is a vital cause of death of women in Indonesia. Every day 40-45 new cases emerge, which means 20-25 people die from cervical cancer in Indonesia. Several previous studies have shown that there are plants, fruits and seeds that contain high antioxidants and are believed to prevent and reduce pain due to cervical cancer. Besides, many herbs that also found in Indonesia are known to affect cancer cells. Ficus auriculata can find in Indonesia. However, not many people use the available natural resources that are suspected to prevent cervical cancer. This study was a preliminary study analyzed of Aristolone in Ara Fruit used as a prediction of apoptosis in HeLa cells. The results showed that the positive effect of Aristolone content in F. auriculata affected proliferation supported by previous studies.

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Section: Resultssupporting

confidence: 57%

Aristolone content analysis in ficus auriculata as predicted apoptotic activity in hela cells

Ambarwati

Jannah

Adawiyah

2021

J. Heal. Technol. Assess. Midwifery

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“…Apoptotic cell death was observed by inverted microscopy and DNA fragmentation by using agarose gel electrophoresis, the results found the cytotoxicity percent of cell proliferation for HT-29 and HepG2 cell lines in F.auriculata extract at 2,000 µg/ml and mitomycin C at 50 µg/ml 31.02±2.11 and 30.56±7.04 respectively. Plant extracts did not show stronger anticancer activity than the positive control 34 .…”

Section: Anticancer Activitymentioning

confidence: 73%

Traditional Uses, Phytochemical and Pharmacological Properties of Ficus auriculata: A Review

Tamta

Mehra

Tandon

2021

J. Drug Delivery Ther.

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Ficus auriculata belongs to family Moraceae. It is also known as Elephant earfig tree because of its large leaves. In India it is commonly known as Timla, Gular , Tirmal, Timal, Timbal, Tremal, Trimmal.. The plants are mainly distributed in temperate, tropical and subtropical regions of about 1800–2600 m altitude. It is native to Asia, especially in India, China, Nepal, Bhutan, Pakistan, Myanmar, Thailand, Vietnam, Malaysia.The plants have great ethnomedicinal importance and are used in traditional folk medicine for curing many ailments in humans. The plants rich in Phytoconstituent e.g. alkaloids, carbohydrates, saponins, glycosides, phytosterols, resins, phenols, tannins, diterpenes, flavonoids, proteins, and amino acids which are present in barks, leaves and fruit extract. The review reveals that huge numbers of phytochemicals which was isolated from the plant possesses the biological and pharmacological properties are shown by the bark, leaves and fruits extract of Ficus auriculata i.e antioxidant, antibacterial, hepatoprotective, histopathological studies, toxicity activity, anticancerous, antidiabatic, hyperlipidemic, hyperglycemic and anti-inflammatory. Leaf extract has also an important role in Glutathione level in cardiac and also used as fodder for farming system, for medicinal properties and for further commercial purpose. Keywords: Ficus auriculata, Phytochemistry, Pharmacological Activity, Herbal Medicine

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“…Positive controls were considered in 4 studies. They were ellipticine and doxorubicin ( Nanasombat and Teckchuen, 2009 ); catechin, trolox, and ascorbic acid ( Woraratphoka et al, 2012 ); mitomycin ( Putthawan et al, 2017 ); and vincristine ( Semsri et al, 2018 ). The concentration of the extracts used in each assay varied.…”

Section: Resultsmentioning

confidence: 99%

“…Several studies have reported diverse bioactive compounds and biological activities of P. odoratum . Its pharmacological activities have been documented and include antibacterial ( Chansiw et al, 2019 ; Řebíčková et al, 2020 ), antifungal ( Yanpirat and Vajrodaya, 2015 ), antioxidant ( Somparn et al, 2013 ; Thongra-ar et al, 2021 ), anti-inflammatory ( Okonogi et al, 2019 ), anti-osteoporosis ( Sungkamanee et al, 2014 ) anticataractogenesis and antiretinopathy ( Wattanathorn et al, 2017 ) and anticancer activities ( Nanasombat and Teckchuen, 2009 ; Putthawan et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activities of Polygonum odoratum Lour.: A Systematic Review

et al. 2022

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Cancers are a potential cause of death worldwide and represent a massive burden for healthcare systems. Treating cancers requires substantial resources, including skilled personnel, medications, instruments, and funds. Thus, developing cancer prevention and treatment measures is necessary for healthcare personnel and patients alike. P. odoratum (Polygonaceae family) is a plant used as a culinary ingredient. It exhibits several pharmacological activities, such as antibacterial, antifungal, antioxidant, anti-inflammatory, and anticancer. Several classes of phytochemical constituents of P. odoratum have been reported. The important ones might be polyphenol and flavonoid derivatives. In this systematic review, the activities of P. odoratum against cancerous cells were determined and summarized. Data were obtained through a systematic search of electronic databases (EMBASE, PubMed, Scopus, Thai Thesis Database, Science Direct and Clinical Key). Eight studies met the eligibility criteria. The cancerous cell lines used in the studies were lymphoma, leukemia, oral, lung, breast, colon, and liver cancer cells. Based on this review, P. odoratum extracts significantly affected Epstein-Barr virus (EBV) genome-carrying human lymphoblastoid (Raji), mouse lymphocytic leukemia (P388), human acute lymphocytic leukemia (Jurkat), breast adenocarcinoma (MCF-7), human colon adenocarcinoma (HT-29), human T lymphoblast (MOLT-4), human promyelocytic leukemia cell line (HL-60), human hepatocellular carcinoma (HepG2), and oral squamous cell carcinoma (SAS, SCC-9, HSC-3) through induction of cell apoptosis, arrest of the cell cycle, inhibition of cell proliferation, migration, and colonization. The molecular mechanism of P. odoratum against cancers was reported to involve suppressing essential proteins required for cell proliferation, colonization, migration, apoptosis, and angiogenesis. They were survivin, cyclin-D, cyclooxygenase 2 (COX-2), matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor A (VEGF-A). The extract of P. odoratum was also involved in the protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway by inhibiting the expression of Akt, phosphorylated Akt, mTOR, and phosphorylated mTOR. From the key results of this review, P. odoratum is a promising chemotherapy and chemopreventive agent. Further investigation of its pharmacological activity and mechanism of action should be conducted using standardized extracts. In vivo experiments and clinical trials are required to confirm the anticancer activity.

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Cytotoxic activity and apoptotic induction of some edible Thai local plant extracts against colon and liver cancer cell lines

Cited by 9 publications

References 17 publications

Aristolone content analysis in ficus auriculata as predicted apoptotic activity in hela cells

Aristolone content analysis in ficus auriculata as predicted apoptotic activity in hela cells

Traditional Uses, Phytochemical and Pharmacological Properties of Ficus auriculata: A Review

Anticancer Activities of Polygonum odoratum Lour.: A Systematic Review

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