White-sided dolphin metallothioneins: purification, characterisation and potential role

Das, Krishna; Jacob, Valérie; Bouquegneau, Jean-Marie

doi:10.1016/s1532-0456(02)00011-x

Cited by 23 publications

(31 citation statements)

References 22 publications

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“…The differences in metal binding, stability, and expression between the MTs forms in vertebrate animals are also reported (Kito et al 1982;Olsson and Hogstrand 1987;Kershaw and Klaassen 1992;Muto et al 1999;Olsvik et al 2000;Lacorn et al 2001;Das et al 2002). In our study, the destruction of MT-2 upon the effect of non-favorable conditions at the U site is observed.…”

Section: Discussionsupporting

confidence: 79%

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Seasonal and spatial comparison of metallothioneins in frog Rana ridibunda from feral populations

2008

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The aim of this study was to elucidate the seasonal and spatial regularity of the properties of metallothioneins (MTs) from the liver and kidney of the frog Rana ridibunda in rural (R) and urban (U) sites in Western Ukraine. This allowed examination of their possibility use in biomonitoring of environmental quality. The positive correlation for Zn and negative correlation for Cu were reflected between their content in the liver and MTs. The content of MTs was higher in summer compared to other seasons and also at the U site compare to the R site. MTs had been comprised of two chromatographic forms (MT-1 and MT-2/MT-2a), with lesser and variable MT-2/2a in frogs from the U site, particularly in the kidney. MTs accumulated about 75% of Cd in the liver. In summary, the ability MTs to elevate content as a stress response, together with the sensitivity of MT-2, may be explored to understand the health status of the frog in each season, reflecting the higher overall anthropogenic impact at the U site.

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Section: Discussionsupporting

confidence: 79%

“…However, the experience of such use of MTs is mostly restricted to the estimation of their content. The diversity of MTs forms and their metal-binding function is poorly understood (Lacorn et al 2001;Das et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Seasonal and spatial comparison of metallothioneins in frog Rana ridibunda from feral populations

2008

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“…It has also been observed that MeHg exposure exerts an inhibitory effect on paraoxonase 1 activity, which can be counteracted by selenium in humans [125]. Other hypotheses are that: (i) selenium can promote the redistribution of Hg from more sensitive organs (kidney, central nervous system) to less sensitive ones (muscle), and that there is competition from Se for the same receptors; (ii) complexes such as tiemannite [126] or SeHg-S [127] are formed, or; (iii) the conversion of MeHg + into less toxic forms is promoted and oxidative damage is prevented [128]. In addition, Yang et al proposed that Se is involved in the demethylation of MeHg + in the liver to form less toxic inorganic Hg compounds [129]; other authors later proposed the same mechanism in octopus [130].…”

Section: Interaction Mechanismsmentioning

confidence: 99%

Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

et al. 2012

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The fact that the essential or toxic character of elements is species specific has encouraged the development of analytical strategies for chemical speciation over the last twenty years; indeed, there are now a great number of them that provide very good performance. However, biological systems are exposed to a complex environment in which species of elements can interact in a synergistic/antagonistic fashion. Thus, the metabolism of trace elements cannot be considered in isolation. On the other hand, biological systems are dynamic, so it is necessary to study the trafficking of species of elements between organs, tissues or cell compartments in order to decipher the biochemical processes of the interactions in which they are involved. Although the application of liquid chromatography-inductively coupled plasma-based "metallomics" methods in combination with organic mass spectrometry can provide much-needed insight, new analytical strategies are required to really understand the role of species of elements in biological systems and the mechanisms of their interactions. In the present paper, the interactions of the most widely studied elements in this context (Se, Hg and As) are discussed, as well as other important interactions between different elements.

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“…In marine mammals they were associated with the homeostasis of essential metals and defenses of Cd effects, in both pinnipeds (Ikemoto et al, 2004a;Pillet et al, 2002;Sonne et al, 2009;Teigen et al, 1999) and cetaceans (Das et al, 2002(Das et al, , 2004(Das et al, , 2006Falconer et al, 1983;Ikemoto et al, 2004b). Therefore, metallothioneins are considered as valid biomarkers in medicine (Carpene et al, 2007) and environmental studies (Blackmore and Wang, 2004;Teigen et al, 1999;Sheehan et al, 1995;Sonne et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Metallothioneins pattern during ontogeny of coastal dolphin, Pontoporia blainvillei, from Argentina

Polizzi¹,

Romero²,

Boudet³

et al. 2014

Marine Pollution Bulletin

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a b s t r a c tMetallothioneins are signals of metal exposure and widely used in biomonitoring. Franciscana dolphin is an endemic cetacean from the Southwestern Atlantic Ocean, classified as Vulnerable A3d by the IUCN. Metallothionein, copper and zinc in Franciscana were assessed in two geographic groups; one inhabits La Plata River estuary, anthropogenically impacted, and the other inhabits marine coastal ecosystems, with negligible pollution. Despite the environment, hepatic and renal MT concentrations were similar, but there was a declining trend from early to later developmental stages. Metallothionein K/L, Cu and Zn levels corresponded to normal reported ranges. MT was not related with Cd. Fetal concentrations were higher than its mother. These results and the health status of dolphins are suggesting that MT correspond to physiological ranges for the species, and they are closely to homeostasis of Zn and Cu, according to its ontogenetic changes. The information constitutes the first MT information on Franciscana dolphin and can be considered as baseline for the species conservation.

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White-sided dolphin metallothioneins: purification, characterisation and potential role

Cited by 23 publications

References 22 publications

Seasonal and spatial comparison of metallothioneins in frog Rana ridibunda from feral populations

Seasonal and spatial comparison of metallothioneins in frog Rana ridibunda from feral populations

Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

Metallothioneins pattern during ontogeny of coastal dolphin, Pontoporia blainvillei, from Argentina

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