White Matter Tractography in Bipolar Disorder and Schizophrenia

McIntosh, Andrew M.; Maniega, Susana Muñoz; Lymer, G. Katherine S.; McKirdy, James; Hall, Jérémy; Sussmann, Jessika E.; Bastin, Mark E.; Clayden, Jonathan D.; Johnstone, Eve C.; Lawrie, Stephen M.

doi:10.1016/j.biopsych.2008.07.026

Cited by 238 publications

(179 citation statements)

References 32 publications

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“…In silico work predicts that this variant may act as a binding site for a myelin transcription factor, serving as a link to shared findings of oligodendrocyte and myelin disruption in the postmortem brain in both schizophrenia and bipolar disorder (Riley et al, 2010). In vivo, evidence has accumulated that corticocortical white matter tracts may be disrupted in schizophrenia (Voineskos et al, 2010b) and in bipolar disorder (McIntosh et al, 2008). However, postmortem data demonstrating oligodendrocyte gene downregulation and reduced oligodendrocyte number in these disorders emerge primarily from studies that have sampled tissues from the cortical gray matter (Tkachev et al, 2003).…”

Section: Introductionmentioning

confidence: 97%

“…In particular, DTI tractography can be used to measure major white matter connections between brain regions that are essential for effective corticocortical communication (Catani et al, 2002). Although there are unique findings for each disorder, recent evidence is emerging suggesting that alterations in cortical thickness (Rimol et al, 2010) and white matter tract integrity (McIntosh et al, 2008) may be shared neural vulnerability phenotypes for schizophrenia and bipolar disorder.…”

Section: Introductionmentioning

confidence: 99%

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The ZNF804A Gene: Characterization of a Novel Neural Risk Mechanism for the Major Psychoses

Voineskos

Lerch

Felsky

et al. 2011

Neuropsychopharmacol

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Schizophrenia and bipolar disorder share genetic risk, brain vulnerability, and clinical symptoms. The ZNF804A risk variant, rs1344706, confers susceptibility for both disorders. This study aimed to identify neural mechanisms common to both schizophrenia and bipolar disorder through this variant's potential effects on cortical thickness, white matter tract integrity, and cognitive function. Imaging, genetics, and cognitive measures were ascertained in 62 healthy adults aged between 18 and 59 years. High-resolution multimodal MRI/DTI imaging was used to measure cortical thickness and major frontotemporal and interhemispheric white matter tracts. The general linear model was used to examine the influence of the ZNF804A rs1344706 risk variant on cortical thickness, white matter tract integrity, and cognitive measures. Individuals homozygous for the risk variant ('A' allele) demonstrated reduced cortical gray matter thickness in the superior temporal gyrus, and in the anterior and posterior cingulate cortices compared with C-allele carriers. No effect of the risk variant on microstructural integrity of white matter tracts was found. Reduced attention control was found in risk allele homozygotes, aligning with findings in the anterior cingulate cortex. Our data provide a novel, genetically based neural risk mechanism for the major psychoses by effects of the ZNF804A risk variant on neural structures and cognitive function susceptible in both disorders. Our findings link genetic, imaging, and cognitive susceptibility relevant to both schizophrenia and bipolar disorder.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

The ZNF804A Gene: Characterization of a Novel Neural Risk Mechanism for the Major Psychoses

Voineskos

Lerch

Felsky

et al. 2011

Neuropsychopharmacol

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“…1,2 These deficits have been recently localized to the anterior thalamic radiation (ATR) using tractography. 3 Neuregulin-1 (NRG1) is a gene associated with risk for schizophrenia 4 and bipolar disorder 5 as well as with white matter density and integrity in the medial prefrontal cortex 6 and the ALIC. 7 In this study, tractography reveals that these NRG1 effects can also be localized to the ATR.…”

mentioning

confidence: 99%

“…Left and right ATR were automatically segmented in each subject using neighbourhood tractography 8 as previously implemented. 3 The resulting tracts were checked by eye, blind to genotype group, and those that were truncated, branched or deviated from the expected anatomical structure were discarded. A mean fractional anisotropy (FA) value, weighted according to the likelihood of connection between the voxel and the seed point, was calculated for the left and the right ATR in each subject.…”

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confidence: 99%

The relationship of anterior thalamic radiation integrity to psychosis risk associated neuregulin-1 variants

et al. 2009

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“…From the DTI data, FA, ADC, and DEC (directionally encoded color) maps were reconstructed to visualize white matter fiber tracts and functional connectivity using dTV.II.R2 software Volume-one 1.72 (The Laboratory of Image Calculation and Analysis, Tokyo University) (24)(25)(26)(27). Three regions of interest (ROIs), each with diameter of 2 mm and size of 7 voxels, were placed on the FA map at three locations of optic radiations near the cornu occipitale.…”

Section: Dti and Dtt Data Processingmentioning

confidence: 99%

Visual pathway lesion and its development during hyperbaric oxygen treatment: A bold‐ fMRI and DTI study

Chen

Yang

et al. 2010

Magnetic Resonance Imaging

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Purpose: To characterize and evaluate functional and anatomic changes of visual pathway lesions during hyperbaric oxygen (HBO) treatment with blood-oxygenation-level-dependent functional MRI (BOLD-fMRI) and diffusion tensor imaging (DTI). Materials and Methods:Sixteen patients with visual pathway lesions received HBO treatment. Both BOLDfMRI and DTI were performed before and after the treatment, while 12 healthy subjects were also studied with 2 examinations as control. The t-tests were used for the comparison of number of activated voxels (AVs) and fractional anisotropy (FA) between the two groups, and within the patient group before and after HBO treatment. Visual acuity of the patient group before and after the treatment was compared using Wilcoxon signed-rank test.Results: Before the treatment, both AVs (P < 0.01) and FA (P < 0.05) in the bilateral cortexes of occipital lobes were significantly less in the patient group than in the control group. After the treatment, both AVs (P < 0.05) and FA (P < 0.05) were significantly increased. Moreover, The FA of 6 patients with lesions in the optical nerve was greater than the FA of the other 10 patients with lesions in the optic radiation (P < 0.05).Conclusion: BOLD-fMRI combined with DTI was useful for the characterization and evaluation of anatomic and functional changes of visual pathway lesions and their development during HBO treatment.

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White Matter Tractography in Bipolar Disorder and Schizophrenia

Cited by 238 publications

References 32 publications

The ZNF804A Gene: Characterization of a Novel Neural Risk Mechanism for the Major Psychoses

The ZNF804A Gene: Characterization of a Novel Neural Risk Mechanism for the Major Psychoses

The relationship of anterior thalamic radiation integrity to psychosis risk associated neuregulin-1 variants

Visual pathway lesion and its development during hyperbaric oxygen treatment: A bold‐ fMRI and DTI study

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