The relationship of anterior thalamic radiation integrity to psychosis risk associated neuregulin-1 variants

Sprooten, Emma; Lymer, G. Katherine S.; Maniega, Susana Muñoz; McKirdy, James; Clayden, Jonathan D.; Bastin, Mark E.; Porteous, David J.; Johnstone, Eve C.; Lawrie, Stephen M.; Hall, Jérémy; McIntosh, Andrew M.

doi:10.1038/mp.2008.136

Cited by 44 publications

(14 citation statements)

References 9 publications

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“…Interestingly, as opposed to the GM findings, both the Self Impact and the Social-Emotional Impact show an inverse correlation to WM integrity (i.e., FA) in the anterior thalamic radiations. The anterior thalamic radiation is the primary path from the ventral medial frontal cortex, inferior frontal gyrus, and dorsolateral prefrontal cortex to the thalamus [51] and shows reductions in relation to psychiatric conditions such as schizophrenia and bipolar disorder [52], [53]. In previous research we have found increases in this tract during adolescence longitudinally [21], the current research suggests that failure to increase FA in this region may accompany distortions of self world concept along affective domains.…”

Section: Discussionsupporting

confidence: 55%

The Parametric, Psychological, Neuropsychological, and Neuroanatomical Properties of Self and World Evaluation

et al. 2012

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BackgroundAs an individual moves from adolescence to adulthood, they need to form a new sense of self as their environment changes from a limited to a more expansive structure. During this critical stage in development the last dramatic steps of neural development occur and numerous psychiatric conditions begin to manifest. Currently, there is no measure that aids in the quantification of how the individual is adapting to, and conceptualizing their role in, these new structures. To fill this gap we created the Self and World Evaluation Expressions Test(SWEET).MethodSixty-five young adults (20.6 years-old), 36 with a history of drug use, completed the SWEET. A factor analysis was performed on the SWEET and the resultant factors were correlated with psychological, neuropsychological, and neuroanatomical battery that included both T1-wieghted and diffusion tensor magnetic resonance imaging scans.ResultsWe derived four factors: Self, Social-Emotional, Financial-Intellectual, and Spirituality. While showing limited relationships to psychological and neuropsychological measures, both white matter integrity and gray matter density showed significant relationships with SWEET factors.ConclusionsThese findings suggest that while individual responses may not be indicative of psychological or cognitive processes they may relate to changes in brain structure. Several of these structures, such as the negative correlation of the affective impact of world with the dorsal anterior corpus callosum white matter integrity have been observed in psychiatric conditions (e.g., obsessive-compulsive disorder). Further longitudinal research using the SWEET may help understand the impact of dramatic shifts in self/world conceptualization and potentially link these shifts to underlying changes in brain structure.

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Section: Discussionsupporting

confidence: 55%

The Parametric, Psychological, Neuropsychological, and Neuroanatomical Properties of Self and World Evaluation

et al. 2012

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“…rs6994992,originally identified as part of the so-called deCODE haplotype, could be specifically related to disruption of normal frontal and temporal lobe function, premorbid intelligence levels and the emergence of psychotic symptoms (Harrison and Law, 2006; Li et al, 2006). Individuals with the TT genotype at this SNP also had reduced white matter density and structural connectivity (McIntosh et al, 2008), impaired frontal and temporal lobe activation (Hall et al, 2006), and cognition (Hall et al, 2006; Stefanis et al, 2007; Sprooten et al, 2009), including reduced spatial working memory capacity (Stefanis et al, 2007) and emotion processing (Keri and Kelemen, 2008). …”

Section: Discussionmentioning

confidence: 99%

Association study of Neuregulin-1 gene polymorphisms in a north Indian schizophrenia sample

Kukshal¹,

Bhatia²,

Bhagwat³

et al. 2013

Schizophrenia Research

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Background Neuregulin-1 (NRG1) gene polymorphisms have been proposed as risk factors for several common disorders. Associations with cognitive variation have also been tested. With regard to Schizophrenia (SZ) risk, studies of Caucasian ancestry samples indicate associations more consistently than East Asian samples, suggesting heterogeneity. To exploit the differences in linkage disequilibrium (LD) structure across ethnic groups, we conducted a SZ case-control study (that included cognitive evaluations) in a sample from the north Indian population. Methods NRG1 variants (n= 35 SNPs, three microsatellite markers) were initially analyzed among cases (DSM IV criteria, n = 1007) and controls (n=1019, drawn from two groups) who were drawn from the same geographical region in North India. Nominally significant associations with SZ were next analyzed in relation to neurocognitive measures estimated with a computerized neurocognitive battery in a subset of the sample (n=116 cases, n=170 controls). Results Three variants and one microsatellite showed allelic association with SZ (rs35753505, rs4733263, rs6994992, and microsatellite 420 M9-1395, p ≤ 0.05 uncorrected for multiple comparisons). A six marker haplotype 221121 (rs35753505-rs6994992-rs1354336-rs10093107-rs3924999-rs11780123) showed (p=0.0004) association after Bonferroni corrections. Regression analyses with the neurocognitive measures showed nominal (uncorrected) associations with emotion processing and attention at rs35753505 and rs6994992, respectively. Conclusions Suggestive associations with SZ and SZ-related neurocognitive measures were detected with two SNPs from the NRG1 promoter region in a north Indian cohort. The functional role of the alleles merits further investigation.

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“…In addition, white matter integrity across diffuse regions of the brain was found to correlate with cyclothymic personality traits, suggesting white matter deficits are related to bipolar symptoms even in unaffected individuals. Dr McIntosh’s group has begun to study the molecular genetic basis for these changes, showing that putative risk variants in the NRG-1 and Erb4 genes are related to white matter integrity of the anterior limb of the internal capsule and anterior thalamic radiation (McIntosh, et al, 2008; Sprooten, et al, 2009). …”

Section: Vi: Geneticsmentioning

confidence: 99%

The 2nd Schizophrenia International Research Society Conference, 10–14 April 2010, Florence, Italy: Summaries of oral sessions

Baharnoori

Bartholomeusz

Boucher³

et al. 2010

Schizophrenia Research

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The 2nd Schizophrenia International Research Society Conference, was held in Florence, Italy, April 10–15, 2010. Student travel awardees served as rapporteurs of each oral session and focused their summaries on the most significant findings that emerged from each session and the discussions that followed. The following report is a composite of these reviews. It is hoped that it will provide an overview for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but who would be interested in an update on current investigations ongoing in the field of schizophrenia research.

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The relationship of anterior thalamic radiation integrity to psychosis risk associated neuregulin-1 variants

Cited by 44 publications

References 9 publications

The Parametric, Psychological, Neuropsychological, and Neuroanatomical Properties of Self and World Evaluation

The Parametric, Psychological, Neuropsychological, and Neuroanatomical Properties of Self and World Evaluation

Association study of Neuregulin-1 gene polymorphisms in a north Indian schizophrenia sample

The 2nd Schizophrenia International Research Society Conference, 10–14 April 2010, Florence, Italy: Summaries of oral sessions

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