White Matter Lesions as a Predictor of Depression in the Elderly: The 3C-Dijon Study

Godin, O.; Dufouil, Carole; Maillard, Pauline; Delcroix, Nicolas; Mazoyer, Bernard; Crivello, Fabrice; Alpérovitch, Annick; Tzourio, Christophe

doi:10.1016/j.biopsych.2007.09.006

Cited by 130 publications

(122 citation statements)

References 30 publications

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“…Cross-sectional associations between WMLs and depression have been shown repeatedly, especially for MRI and mainly from clinical studies (Greenwald et al, 1998;Ikram et al, 2010;Kumar et al, 2000;Kumar et al, 2002), although not all studies support this association (Rainer et al, 2006;Skoog et al, 1994). Our finding that WMLs preceded major depression is in agreement with three previous longitudinal studies using MRI (Godin et al, 2008;Steffens et al, 2002;Teodorczuk et al, 2007). However, two longitudinal population-based studies did not support this association (Ikram et al, 2010;Versluis et al, 2006).…”

Section: Discussionsupporting

confidence: 84%

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Temporal Lobe Atrophy and White Matter Lesions are Related to Major Depression over 5 years in the Elderly

Olesen

Gustafson

Simoni

et al. 2010

Neuropsychopharmacol

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The influence of organic brain changes on the development of depression in the elderly is uncertain. Cross-sectional studies, most often from clinical samples, report associations with brain atrophy and cerebrovascular disease, while longitudinal population studies have given mixed results. Our aim was to investigate whether cortical atrophy and white matter lesions (WMLs) on computed tomography (CT) predict occurrence of depression in the elderly. This is a prospective population-based study with 5-year follow-up. The baseline sample included 525 elderly subjects, aged 70-86 years, without dementia or major depression, with a score on the Mini-Mental State Examination above 25, and without dementia at follow-up. Cortical atrophy and WMLs were evaluated at baseline using CT. The main outcome measure was development of major or minor depression at follow-up according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition, as evaluated using neuropsychiatric examinations and hospital discharge registers. Logistic regression was used to estimate risk. Over the period of 5 years, 20 individuals developed major and 63 minor depression. Presence of temporal lobe atrophy (odds ratio (OR) ¼ 2.81, 95% confidence interval (CI) 1.04-7.62) and moderate-to-severe WMLs (OR ¼ 3.21, 95% CI 1.00-10.26) independently predicted major, but not minor, depression after controlling for various confounders. Other brain changes did not predict occurrence of depression. Our findings suggest that temporal lobe atrophy and WMLs represent relatively independent and complementary pathways to major depression in the elderly. This may have implications for prevention, as both neurodegeneration and cerebrovascular disease have been related to preventable factors.

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Section: Discussionsupporting

confidence: 84%

“…The results from longitudinal population-based studies are conflicting. Three studies using MRI reported that WMLs increased the risk of subsequent depression (Godin et al, 2008;Steffens et al, 2002;Teodorczuk et al, 2007) while two could not confirm these findings (Ikram et al, 2010;Versluis et al, 2006).…”

Section: Introductionmentioning

confidence: 97%

Temporal Lobe Atrophy and White Matter Lesions are Related to Major Depression over 5 years in the Elderly

Olesen

Gustafson

Simoni

et al. 2010

Neuropsychopharmacol

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“…7,10,11 Previous studies have shown associations of CFPWV or local carotid stiffness with various manifestations of cerebral small vessel disease, including WMHV 6,12,17 and subcortical or lacunar infarcts. 6,12,17 In addition, previous studies have shown an association between depression and WMHV 19,38 and lacunar infarcts. 38,39 Furthermore, a population-based study 4 has shown that higher CFPWV and local carotid stiffness were associated with depression.…”

Section: Discussionmentioning

confidence: 92%

Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study

Sloten

Mitchell

Sigurðsson

et al. 2016

jpn

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“…10,11 Briefly, 4,931 noninstitutionalized persons aged 65 years and older were recruited from the electoral rolls of Dijon, France, between March 1999 and March 2001. Participants enrolled between June 1999 and September 2000, younger than 80 years, and who were able to come to the examination center (n 5 2,763) were invited to undergo a brain MRI.…”

Section: Methods Population and Study Design The 3c-dijonmentioning

confidence: 99%

Large-vessel correlates of cerebral small-vessel disease

et al. 2013

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Objective: Our aim was to investigate the relationship of carotid structure and function with MRI markers of cerebral ischemic small-vessel disease.Methods: The study comprised 1,800 participants (aged 72.5 6 4.1 years, 59.4% women) from the 3C-Dijon Study, a population-based, prospective cohort study, who had undergone quantitative brain MRI and carotid ultrasound. We used multivariable logistic and linear regression adjusted for age, sex, and vascular risk factors.Results: Presence of carotid plaque and increasing carotid lumen diameter (but not common carotid artery intima-media thickness) were associated with higher prevalence of lacunar infarcts: odds ratio ( Conclusions: In addition to and independently of carotid plaque, increasing carotid lumen diameter and markers of carotid stiffness were associated with increasing prevalence of lacunar infarcts and increasing WMHV, respectively. Neurology â 2013;80:662-669 GLOSSARY BI 5 brain infarct; CCA 5 common carotid artery; CI 5 confidence interval; IMT 5 intima-media thickness; LI 5 lacunar infarct; L-WMHV 5 large white matter hyperintensity volume; OR 5 odds ratio; SVD 5 small-vessel disease; WMH 5 white matter hyperintensity; WMHV 5 white matter hyperintensity volume.Brain imaging studies have shown that the impact of ischemic brain injury, a major cause of disability, dementia, and mortality in adults, 1 extends much beyond that of acute clinical events such as stroke. Vascular lesions, including MRI-defined brain infarcts (BIs) and white matter hyperintensities (WMH), are frequently observed in older community-dwelling individuals. The prevalence of BIs ranges between 8% and 28% 2,3

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White Matter Lesions as a Predictor of Depression in the Elderly: The 3C-Dijon Study

Abstract: Our data show that depression and WML volumes are strongly related. These results are consistent with the hypothesis of a vascular depression in the elderly.

Cited by 130 publications

References 30 publications

Temporal Lobe Atrophy and White Matter Lesions are Related to Major Depression over 5 years in the Elderly

Temporal Lobe Atrophy and White Matter Lesions are Related to Major Depression over 5 years in the Elderly

Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study

Large-vessel correlates of cerebral small-vessel disease

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