White-Matter Hyperintensities and Lacunar Infarcts Are Associated with an Increased Risk of Alzheimer's Disease in the Elderly in China

Ye, Shuai; Dong, Shengjie; Tan, Jun; Chen, Le; Hai, Yang; Cs, Yang; Peng, Zeyan; Huo, Yingchao; Liu, Juan; Tang, Mingshan; Li, Yafei; Zhou, Hua‐Dong; Tao, Yong

doi:10.3988/jcn.2019.15.1.46

Cited by 16 publications

(14 citation statements)

References 47 publications

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“…When multiple markers of CSVD are present at the same time, they may have synergistic or superimposed effects on cognitive dysfunction ( Jokinen et al, 2012 ; Ye et al, 2019 ). The underlying mechanism of CSVD leading to cognitive impairment is still under investigation.…”

Section: Discussionmentioning

confidence: 99%

Higher Total Cerebral Small Vessel Disease Burden Was Associated With Mild Cognitive Impairment and Overall Cognitive Dysfunction: A Propensity Score-Matched Case–Control Study

Yuan

Qin

et al. 2021

Front. Aging Neurosci.

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Background and ObjectiveThe combination of neuroimaging and cognition characteristics may provide complementary information for early identification of mild cognitive impairment (MCI). This study aimed to establish the clinical relevance between cerebral small vessel disease (CSVD) burden and MCI and further explored the cognitive characteristics linked to CSVD applying a propensity score matching (PSM) approach.MethodsThe study was designed as a case–control study. All the subjects underwent the standard clinical assessments, neuropsychological testing battery (including global cognition, memory, executive function, and speed and motor control domains), and brain magnetic resonance imaging (MRI). A 1:2 nearest-neighbor matching approach without replacement was employed with a caliper of 0.15 in the PSM approach.ResultsA total of 84 MCI patients and 186 cognitively normal controls were included in this study. After PSM, 74 MCI patients and 129 controls were successfully matched, and the covariate imbalance was well eliminated. Compared with controls, the MCI group had more severe CSVD burden. In the binary logistic regression analysis, CSVD was associated with MCI after adjusting for all confounders. The results of multivariate linear regression analyses showed that higher total MRI CSVD burden was related to the deficit of cognitive performance in global cognition and three important cognitive domains after adjusting for all confounders.ConclusionCerebral small vessel disease was an independent risk factor of MCI. Moreover, higher total MRI CSVD burden was associated with the overall cognitive impairment among middle-aged and elderly Chinese adults.

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Section: Discussionmentioning

confidence: 99%

Higher Total Cerebral Small Vessel Disease Burden Was Associated With Mild Cognitive Impairment and Overall Cognitive Dysfunction: A Propensity Score-Matched Case–Control Study

Yuan

Qin

et al. 2021

Front. Aging Neurosci.

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“…From June 1, 2020, to December 31, 2021, patients diagnosed with AD at the rehabilitation department or neurology department of the Chongqing Daping Hospital were recruited to participate in our study. AD was diagnosed by a senior neurologist following a previously described protocol [14]. All patients participating in the study underwent MRI examination.…”

Section: Subjectsmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation Decreases Serum Amyloid-β and Increases Ectodomain of p75 Neurotrophin Receptor in Patients with Alzheimer’s Disease

Tao¹,

Liu²,

Zhu³

et al. 2022

J. Integr. Neurosci.

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Background: This study investigated the impact of repetitive transcranial magnetic stimulation (rTMS) on serum levels of Amyloid-β (Aβ) as well as the ectodomain of p75 neurotrophin receptor (p75ECD) in patients with Alzheimer's disease (AD). Methods: A total of 46 patients diagnosed with AD between June 1, 2020 and December 31, 2021 were randomized to undergo either 20 Hz rTMS treatment of the left dorsolateral prefrontal cortex (DLPFC) or sham procedure. Cognitive function and activity of daily living were evaluated. Neuropsychological tests and blood samples were gathered at baseline and at 2, 3, 4, and 6 weeks after rTMS therapy. Results: There were no evident differences between rTMS group and sham group in serum Aβ40, Aβ42, total Aβ, ApoE, and p75ECD standards at baseline (p > 0.05). Serum levels of Aβ40, Aβ42, as well as total Aβ, were significantly lower in the rTMS group at 3, 4 and 6 weeks relative to the sham group (p < 0.05). Serum p75ECD levels in the rTMS group were significantly higher than those of the sham group at 3, 4 and 6 weeks (p < 0.05). Levels of serum Aβ40 (r: -0.78, -0.83, -0.68, respectively), Aβ42 (r: -0.76, -0.76, -0.61, respectively) and total Aβ (r: -0.74, -0.81, -0.66, respectively) were negatively correlated with MoCA, MMSE and MBI scores, while serum p75ECD levels (r: 0.84, 0.90, 0.72, respectively) were positively correlated (p < 0.01). The level of serum Aβ40 (r = 0.77), Aβ42 (r = 0.69) as well as total Aβ (r = 0.73) were positively correlated with ADAS-cog score, while p75ECD levels (r = -0.86) were negatively correlated (p < 0.01). Conclusions: The results of this study suggest that rTMS may decrease serum Aβ levels and increase serum p75ECD levels in patients with AD, offering insight into a potential underpinning mechanism of rTMS.

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“…WMH has been widely accepted in imaging associations with aging and AD (Chen et al, 2011). For example, a longitudinal study showed that a high burden of WMH was associated with an increased risk of developing AD over a 5-year follow-up period (Ye et al, 2019). One cohort study showed that overall WMH load was associated with AD risk factors in subjects whose cognitive function was not impaired.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Association of Cerebral Small Vessel Disease With Gait and Balance Disorders

Yang

Wei

et al. 2022

Front. Aging Neurosci.

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Cerebral small vessel disease (CSVD) is a common cerebrovascular disease and an important cause of gait and balance disorders. Gait and balance disorders can further lead to an increased risk of falls and a decreased quality of life. CSVD can damage gait and balance function by affecting cognitive function or directly disrupting motor pathways, and different CSVD imaging features have different characteristics of gait and balance impairment. In this article, the correlation between different imaging features of sporadic CSVD and gait and balance disorders has been reviewed as follows, which can provide beneficial help for standardized management of CSVD.

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White-Matter Hyperintensities and Lacunar Infarcts Are Associated with an Increased Risk of Alzheimer's Disease in the Elderly in China

Cited by 16 publications

References 47 publications

Higher Total Cerebral Small Vessel Disease Burden Was Associated With Mild Cognitive Impairment and Overall Cognitive Dysfunction: A Propensity Score-Matched Case–Control Study

Higher Total Cerebral Small Vessel Disease Burden Was Associated With Mild Cognitive Impairment and Overall Cognitive Dysfunction: A Propensity Score-Matched Case–Control Study

Repetitive Transcranial Magnetic Stimulation Decreases Serum Amyloid-β and Increases Ectodomain of p75 Neurotrophin Receptor in Patients with Alzheimer’s Disease

Association of Cerebral Small Vessel Disease With Gait and Balance Disorders

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