White Matter Density in Patients with Schizophrenia, Bipolar Disorder and Their Unaffected Relatives

McIntosh, Andrew M.; Job, Dominic; Moorhead, T. William J.; Harrison, Lesley K.; Lawrie, Stephen M.; Johnstone, Eve C.

doi:10.1016/j.biopsych.2005.03.044

Cited by 106 publications

(86 citation statements)

References 19 publications

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“…These regions recapitulate those reported to have reduced WM volume and density, and reductions in fractional anisotropy in prior studies of unaffected relatives of BD patients, 21,22,39,[49][50][51] in addition to those with established BD. 49,[52][53][54][55][56][57][58] The specific involvement of the IFG adds to a converging body of evidence from structural and functional studies of BD.…”

Section: Discussionsupporting

confidence: 80%

784. Structural Dysconnectivity of Key Cognitive and Emotional Hubs in Young People at High Genetic Risk for Bipolar Disorder

Mitchell

Breakspear

Roberts

et al. 2017

Biological Psychiatry

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Section: Discussionsupporting

confidence: 80%

784. Structural Dysconnectivity of Key Cognitive and Emotional Hubs in Young People at High Genetic Risk for Bipolar Disorder

Mitchell

Breakspear

Roberts

et al. 2017

Biological Psychiatry

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“…2 These findings have been associated with increased genetic liability to psychosis, albeit to unidentified loci 4 and by functional imaging studies in patients with schizophrenia 27,28 and those at high risk for genetic reasons. 29 These studies further implicate white matter disconnectivity in psychosis, although they cannot determine whether this is because of reduced axonal number, increased axonal disorganization or dysmyelination.…”

Section: Discussionmentioning

confidence: 98%

“…Using T 1 -weighted MRI, and DTI, abnormalities of white matter density and integrity have been shown in the ALIC in schizophrenia, 2,3 bipolar disorder 2,26 and their unaffected relatives. 2 These findings have been associated with increased genetic liability to psychosis, albeit to unidentified loci 4 and by functional imaging studies in patients with schizophrenia 27,28 and those at high risk for genetic reasons.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with both conditions show white matter density reductions in the anterior limb of the internal capsule (ALIC) and in prefrontal subgyral white matter using T 1 -weighted magnetic resonance imaging (MRI). 2,3 These abnormalities are shared by unaffected relatives in proportion to their proximity to an affected subject. 4 These findings suggest that white matter density reductions are likely to be associated with shared genetic factors, although no specific genetic variants have yet been found which account for these findings.…”

Section: Introductionmentioning

confidence: 99%

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The effects of a neuregulin 1 variant on white matter density and integrity

et al. 2007

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Theories of abnormal anatomical and functional connectivity in schizophrenia and bipolar disorder are supported by evidence from functional magnetic resonance imaging (MRI), structural MRI and diffusion tensor imaging (DTI). The presence of similar abnormalities in unaffected relatives suggests such disconnectivity is genetically mediated, albeit through unspecified loci. Neuregulin 1 (NRG1) is a psychosis susceptibility gene with effects on neuronal migration, axon guidance and myelination that could potentially explain these findings. In the current study, unaffected subjects were genotyped at the NRG1 single nucleotide polymorphism (SNP) rs6994992 (SNP8NRG243177) locus, previously associated with increased risk for psychosis, and the effect of genetic variation at this locus on white matter density (T 1 -weighted MRI) and integrity (DTI) was ascertained. Subjects with the riskassociated TT genotype had reduced white matter density in the anterior limb of the internal capsule and evidence of reduced structural connectivity in the same region using DTI. We therefore provide the first imaging evidence that genetic variation in NRG1 is associated with reduced white matter density and integrity in human subjects. This finding is discussed in the context of NRG1 effects on neuronal migration, axon guidance and myelination.

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“…1,2 These deficits have been recently localized to the anterior thalamic radiation (ATR) using tractography. 3 Neuregulin-1 (NRG1) is a gene associated with risk for schizophrenia 4 and bipolar disorder 5 as well as with white matter density and integrity in the medial prefrontal cortex 6 and the ALIC.…”

mentioning

confidence: 99%

The relationship of anterior thalamic radiation integrity to psychosis risk associated neuregulin-1 variants

et al. 2009

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White Matter Density in Patients with Schizophrenia, Bipolar Disorder and Their Unaffected Relatives

Cited by 106 publications

References 19 publications

784. Structural Dysconnectivity of Key Cognitive and Emotional Hubs in Young People at High Genetic Risk for Bipolar Disorder

784. Structural Dysconnectivity of Key Cognitive and Emotional Hubs in Young People at High Genetic Risk for Bipolar Disorder

The effects of a neuregulin 1 variant on white matter density and integrity

The relationship of anterior thalamic radiation integrity to psychosis risk associated neuregulin-1 variants

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