White matter changes in patients with mild traumatic brain injury: MRI perspective

Narayana, Ponnada A.

doi:10.2217/cnc-2016-0028

Cited by 76 publications

(61 citation statements)

References 170 publications

(171 reference statements)

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“…Despite reports of alterations in diffusivity measures following concussion, the direction of these changes has been a source of substantial disagreement (Dodd et al, 2014;Eierud et al, 2014;Honce, Nyberg, Jones, & Nagae, 2016;Moore, Kay, & Ellemberg, 2018;Narayana, 2017;Schmidt et al, 2018). Most dMRI studies have focused on adult or mixed age samples in the acute periods following injury, and very few studies have focused on more chronic time points (i.e., greater than 3 or 6 months post-concussion).…”

Section: Introductionmentioning

confidence: 99%

“…However, increased FA has also been observed and may be indicative of cytotoxic edema acutely after injury (Wilde et al, 2008) or a loss of crossing fibers chronically after injury (Henry et al, 2011;Orr et al, 2016). Though often reported in terms of FA, similar inconsistent findings for measures of MD, AD, and RD in the corpus callosum have been reported as well (Eierud et al, 2014;Honce et al, 2016;Moore et al, 2018;Narayana, 2017;Schmidt et al, 2018). Unfortunately, few studies have utilized dMRI in pediatric-only populations with concussion.…”

Section: Introductionmentioning

confidence: 99%

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Microstructure of the Corpus Callosum Long after Pediatric Concussion

Sohn

Virani

Carlson

et al. 2020

J Int Neuropsychol Soc

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Objective: The long-term effects of pediatric concussion on white matter microstructure are poorly understood. This study investigated long-term changes in white matter diffusion properties of the corpus callosum in youth several years after concussion. Methods: Participants were 8–19 years old with a history of concussion (n = 36) or orthopedic injury (OI) (n = 21). Mean time since injury for the sample was 2.6 years (SD = 1.6). Participants underwent diffusion magnetic resonance imaging, completed cognitive testing, and rated their post-concussion symptoms. Measures of diffusivity (fractional anisotropy, mean, axial, and radial diffusivity) were extracted from white matter tracts in the genu, body, and splenium regions of the corpus callosum. The genu and splenium tracts were further subdivided into 21 equally spaced regions along the tract and diffusion values were extracted from each of these smaller regions. Results: White matter tracts in the genu, body, and splenium did not differ in diffusivity properties between youth with a history of concussion and those with a history of OI. No significant group differences were found in subdivisions of the genu and splenium after correcting for multiple comparisons. Diffusion metrics did not significantly correlate with symptom reports or cognitive performance. Conclusions: These findings suggest that at approximately 2.5 years post-injury, youth with prior concussion do not have differences in their corpus callosum microstructure compared to youth with OI. Although these results are promising from the perspective of long-term recovery, further research utilizing longitudinal study designs is needed to confirm the long-term effects of pediatric concussion on white matter microstructure.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microstructure of the Corpus Callosum Long after Pediatric Concussion

Sohn

Virani

Carlson

et al. 2020

J Int Neuropsychol Soc

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“…Listening engages cognitive networks and the precision of sound processing is linked to cognitive skills as attention and working memory (Kraus et al, 2016). These processes activate neural circuits within temporal and frontal cortices (Stanley et al, 2015), which are the areas of neocortex most susceptible to injury in a concussion (Narayana, 2017). Also, multimodal MRI studies identified that corpus callosum (CC), particularly splenium, is the most commonly affected white matter tract in mTBI (Aoki, Inokuchi, Gunshin, Yahagi, & Suwa, 2012) and that CC white matter changes can be associated with graded deficits in working memory (Prins, Hales, Reger, Giza, & Hovda, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…The other indicators of ongoing neuropathology after a concussion are biomarkers such as plasma tau changes (Gill, Merchant‐Borna, Jeromin, Livingston, & Bazarian, ) or white matter changes (Narayana, ). Recently, Kraus et al.…”

Section: Introductionmentioning

confidence: 99%

“…The other indicators of ongoing neuropathology after a concussion are biomarkers such as plasma tau changes (Gill, Merchant-Borna, Jeromin, Livingston, & Bazarian, 2017) or white matter changes (Narayana, 2017). Recently, Kraus et al (2016) have shown that the midbrain electrophysiological responses of concussed athletes reflect impaired auditory processing (Kraus, Anderson, White-Schwoch, Fay, & Popper, 2017).…”

Section: Introductionmentioning

confidence: 99%

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The auditory comprehension changes over time after sport‐related concussion can indicate multisensory processing dysfunctions

Białuńska

Salvatore

2017

Brain and Behavior

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BackgroundAlthough science findings and treatment approaches of a concussion have changed in recent years, there continue to be challenges in understanding the nature of the post‐concussion behavior. There is growing a body of evidence that some deficits can be related to an impaired auditory processing.PurposeTo assess auditory comprehension changes over time following sport‐related concussion (SRC) in young athletes.MethodsA prospective, repeated measures mixed‐design was used. A sample of concussed athletes (n = 137) and the control group consisted of age‐matched, non‐concussed athletes (n = 143) were administered Subtest VIII of the Computerized‐Revised Token Test (C‐RTT). The 88 concussed athletes selected for final analysis (neither previous history of brain injury, neurological, psychiatric problems, nor auditory deficits) were evaluated after injury during three sessions (PC1, PC2, and PC3); controls were tested once. Between‐ and within‐group comparisons using RMANOVA were performed on the C‐RTT Efficiency Score (ES).Results ES of the SRC athletes group improved over consecutive testing sessions (F = 14.7, p < .001), while post‐hoc analysis showed that PC1 results differed from PC2 and PC3 (ts ≥ 4.0, ps < .001), but PC2 and PC3 C‐RTT ES did not change statistically (t = 0.6, p = .557). The SRC athletes demonstrated lower ES for all test session when compared to the control group (ts > 2.0, Ps<.01).ConclusionDysfunctional auditory comprehension performance following a concussion improved over time, but after the second testing session improved performance slowed, especially in terms of its timing. Yet, not only auditory processing but also sensorimotor integration and/or motor execution can be compromised after a concussion.

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A population‐based study of head injury, cognitive function and pathological markers

James

Nicholas

Lane

et al. 2021

Ann Clin Transl Neurol

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Objective To assess associations between head injury (HI) with loss of consciousness (LOC), ageing and markers of later‐life cerebral pathology; and to explore whether those effects may help explain subtle cognitive deficits in dementia‐free individuals. Methods Participants (n = 502, age = 69–71) from the 1946 British Birth Cohort underwent cognitive testing (subtests of Preclinical Alzheimer Cognitive Composite), 18F‐florbetapir Aβ‐PET and MR imaging. Measures include Aβ‐PET status, brain, hippocampal and white matter hyperintensity (WMH) volumes, normal appearing white matter (NAWM) microstructure, Alzheimer’s disease (AD)‐related cortical thickness, and serum neurofilament light chain (NFL). LOC HI metrics include HI occurring: (i) >15 years prior to the scan (ii) anytime up to age 71. Results Compared to those with no evidence of an LOC HI, only those reporting an LOC HI>15 years prior (16%, n = 80) performed worse on cognitive tests at age 69–71, taking into account premorbid cognition, particularly on the digit‐symbol substitution test (DSST). Smaller brain volume (BV) and adverse NAWM microstructural integrity explained 30% and 16% of the relationship between HI and DSST, respectively. We found no evidence that LOC HI was associated with Aβ load, hippocampal volume, WMH volume, AD‐related cortical thickness or NFL (all p > 0.01). Interpretation Having a LOC HI aged 50’s and younger was linked with lower later‐life cognitive function at age ~70 than expected. This may reflect a damaging but small impact of HI; explained in part by smaller BV and different microstructure pathways but not via pathology related to AD (amyloid, hippocampal volume, AD cortical thickness) or ongoing neurodegeneration (serum NFL).

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White matter changes in patients with mild traumatic brain injury: MRI perspective

Cited by 76 publications

References 170 publications

Microstructure of the Corpus Callosum Long after Pediatric Concussion

Microstructure of the Corpus Callosum Long after Pediatric Concussion

The auditory comprehension changes over time after sport‐related concussion can indicate multisensory processing dysfunctions

A population‐based study of head injury, cognitive function and pathological markers

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