White matter changes in first episode psychosis and their relation to the size of sample studied: A DTI study

Melicher, Tomáš; Horáček, Jiří; Hlinka, Jaroslav; Španiel, Filip; Tintěra, Jaroslav; Ibrahim, Ibrahim; Mikoláš, Pavol; Novák, Tomáš; Mohr, Pavel; Höschl, Cyril

doi:10.1016/j.schres.2015.01.029

Cited by 61 publications

(51 citation statements)

References 49 publications

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“…In a subsequent analysis, we explicitly addressed the effect of antipsychotic medication in FEP patients by comparing HC with untreated and antipsychotic-treated FEP patients only. In accordance with recent evidence [16,17,34], we expected that FA would be decreased and MD increased in ARMS and FEP subjects relative to healthy controls and that FA in antipsychotic-treated FEP patients would be increased compared to untreated patients [15]. We further hypothesised that in ARMS and FEP individuals there would be a positive correlation between FA values in the SLF and positive psychotic symptoms [26,27,28,29].…”

Section: Introductionsupporting

confidence: 76%

Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology

Schmidt¹,

Lenz²,

Smieskova³

et al. 2015

Neurosignals

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Background/Aims: Previous diffusion tensor imaging (DTI) studies have shown microstructural changes in the brain white matter of at-risk mental state (ARMS) subjects for psychosis and patients with first-episode psychosis (FEP). However, only a few studies have been conducted in clinical high-risk samples and findings in both groups are inconsistent, in particular along the superior longitudinal fasciculus (SLF). Methods: This DTI study used tract-based spatial statistics (TBSS) to compare fractional anisotropy (FA) and mean diffusivity (MD) between ARMS subjects, untreated and antipsychotic-treated FEP patients and healthy controls (HC) across the whole brain and the SLF. Results: Compared to HC, ARMS and FEP patients showed increased FA and decreased MD in diverse regions across the whole brain including the SLF. FA in the SLF was positively correlated with positive psychotic symptoms in ARMS and FEP individuals. Furthermore, untreated but not treated FEP patients showed increased FA in the left inferior longitudinal fasciculus and right SLF. Conclusion: This study revealed increased FA and decreased MD in early stages of psychosis in widespread white matter tracts including the SLF. Our findings further suggest that microstructural changes in the SLF are probably related to state-dependent psychopathology.

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Section: Introductionsupporting

confidence: 76%

Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology

Schmidt¹,

Lenz²,

Smieskova³

et al. 2015

Neurosignals

View full text Add to dashboard Cite

show abstract

“…On the other hand, superior longitudinal fasciculus is the main white matter tract that connects frontal-parietal regions. Recently, reduced integrity in anterior thalamic radiation and superior longitudinal fasciculus has been reported (41)(42)(43)(44)(45). Besides, a correlation has been found between negative symptoms, cognitive impairment, and white matter disintegrity within these white matter tracts (46,47).…”

Section: Discussionmentioning

confidence: 95%

A combined VBM and DTI study of schizophrenia: bilateral decreased insula volume and cerebral white matter disintegrity corresponding to subinsular white matter projections unlinked to clinical symptomatology

Onay¹,

Eser²,

Ulasoglu-Yildiz³

et al. 2017

Diagn Interv Radiol

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“…For the corpus callosum, both higher FA values in women compared to men 76 , higher FA values in men compared to women 77 , as well as no sex differences 78 have been reported. In patients with schizophrenia, the literature on sex differences in FA is limited, but suggests lower values in women compared to men in the genu 79 and the whole corpus callosum 80 .…”

Section: Sex Differencesmentioning

confidence: 93%

“…It is estimated that genetic factors account for around 85-88% of the individual difference in whole brain WM volume 75,76 . White matter FA shows moderate to high heritability (0.4 -0.7) depending on the tract, and with the exception of the corticospinal tract (lower values).…”

Section: Genes Environment and Microstructural White Mattermentioning

confidence: 99%

“…A recent study by Melicher and colleagues (2015) showed that detected regional FA differences strongly depend on the size of the studied sample. Studies with small samples are at risk for falsely suggesting WM abnormalities in certain re-gions 76 . Therefore, a minimum sample size for diffusion imaging should be imposed, especially if subgroups or statistical interactions are analysed.…”

Section: Sample Sizementioning

confidence: 99%

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White matter changes in first episode psychosis and their relation to the size of sample studied: A DTI study

Cited by 61 publications

References 49 publications

Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology

Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology

A combined VBM and DTI study of schizophrenia: bilateral decreased insula volume and cerebral white matter disintegrity corresponding to subinsular white matter projections unlinked to clinical symptomatology

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