White matter abnormalities in drug‐naïve patients with obsessive–compulsive disorder: a Diffusion Tensor Study before and after citalopram treatment

Yoo, So Young; Jang, Joon Hwan; Shin, Yong-il; Kim, D. J.; Park, Hae Jeong; Moon, Won-Jin; Chung, Eun Chul; Lee, J.-M.; Kim, I. Y.; Kim, S. I.; Kwon, Jun Soo

doi:10.1111/j.1600-0447.2007.01046.x

Cited by 147 publications

(159 citation statements)

References 61 publications

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“…Increased FA in OCD patients compared to controls in the left anterior Corpus Callosum has been found in a study of Yoo et al, 2007. Furthermore, increased FA in the left Insula and decreased FA in the left Occipital lobe in OCD patients have been reported by Nakamae et al, 2008 andSzeszko et al, 2005 Our findings in the MZ discordant twins suggest that these white matter changes found in OCD patients are caused in part by environmental risk factors acting independently from genetic risk factors.…”

Section: Discussionsupporting

confidence: 62%

A DTI Study of Monozygotic Twins Discordant for Obsessive-Compulsive Symptoms

Braber¹,

Ent²,

Cath³

et al. 2009

NeuroImage

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Section: Discussionsupporting

confidence: 62%

A DTI Study of Monozygotic Twins Discordant for Obsessive-Compulsive Symptoms

Braber¹,

Ent²,

Cath³

et al. 2009

NeuroImage

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“…[12][13][14][15] To date, 8 studies have examined white matter pathology in patients with OCD using DTI. 5,[16][17][18][19][20][21][22] However, the findings of these studies have been variable (Table 1), and no study has examined whether axonal injury or abnormal myelination explains the observed findings. In this study, our aim was to extend previous work and to examine alterations in fractional anisotropy as well as measures of axial and radial diffusivity in a sample of patients with OCD and healthy controls using a well-validated Tract-Based Spatial Statistics (TBSS) technique.…”

Section: Introductionmentioning

confidence: 85%

White matter microstructure in patients with obsessive–compulsive disorder

Bora

2011

J Psychiatry Neurosci

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Background: Previous diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination. Methods: In this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls. Results: We found decreased fractional anisotropy in the body of the corpus callosum in the OCD group, which was underpinned by increased radial diffusivity. Limitations: The cross-sectional design was the main limitation. Conclusion: Our findings of increased radial diffusivity provide preliminary evidence for abnormal myelination in patients with OCD.

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“…In another investigation, Yoo et al . [24] investigated the white matter abnormalities of the patients with OCD who were drug-naive by using diffusion tensor-imaging and structural magnetic resonance imaging at baseline and the white matter changes in the patients after twelve weeks of citalopram treatment. They found that drug-naive OCD patients showed significant increases in fractional anisotropy (FA) in the corpus callosum, internal capsule and white matter in the area superolateral to the right caudate compared with helthy controls and that the increases in FA were mostly no longer observed in patients after 12 weeks of treatment compared to control subjects.…”

Section: Functional and Neurochemical Investigationsmentioning

confidence: 99%

The Effects of Psychopharmacologic and Therapeutic Approaches on Neuro-imaging in Obsessive-compulsive Disorder

Atmaca

2013

Current Neuropharmacology

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The neurobiological etiopathogenesis of OCD is still obscure. Neuroimaging studies have been very influential in shaping neurobiological models of OCD. Investigations performed within last twenty years have revealed some important findings and proposed that specific cortico-striato-thalamic circuits are involved in the mediation of its symptoms. The effects of antiobsessional drugs and cognitive behavioral therapy on structural and functional imaging have been evaluated in limited size of investigations. In structural investigations, in summary, it was found key brain regions in the pathophysiology of OCD and amygdala to change volumetrically by treatment. In functional and neurochemical investigations, by using different treatment modalities, cortico-striatal function disablements and NAA changes in a variety of brain regions were reported. In this paper, these limited data are reviewed. It is clear that there is so many things to be performed in the future researches on the effects of therapy on brains of the patients with OCD.

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White matter abnormalities in drug‐naïve patients with obsessive–compulsive disorder: a Diffusion Tensor Study before and after citalopram treatment

Abstract: Our findings suggest that white matter alterations are associated with the pathophysiology of OCD, and the abnormalities may be partly reversible with pharmacotherapy.

Cited by 147 publications

References 61 publications

A DTI Study of Monozygotic Twins Discordant for Obsessive-Compulsive Symptoms

A DTI Study of Monozygotic Twins Discordant for Obsessive-Compulsive Symptoms

White matter microstructure in patients with obsessive–compulsive disorder

The Effects of Psychopharmacologic and Therapeutic Approaches on Neuro-imaging in Obsessive-compulsive Disorder

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