White Blood Cell Count and Haematocrit as Predictors of Coronary Recurrence after Myocardial Infarction

Lowe, G.D.O.; Machado, Stella G.; Król, W; Barton, Bruce; Forbes, C. D.

doi:10.1055/s-0038-1660101

Cited by 109 publications

(39 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This was probably because of the association of sICAM-1 and leucocyte counts demonstrated in the control group. We suppose that the well-known 'smokers' leucocytosis' (Lowe et al, 1985;Schwartz and Weiss, 1994) may account for the elevated serum levels in smokers that lay in the same range as those of patients with localized NSCLC. This possibility should be more carefully considered in future studies, as smokers could be regarded as a more obvious control group for patients with lung cancer than healthy non-smokers.…”

Section: Discussionmentioning

confidence: 95%

Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1, CD54) in patients with non-small-cell lung cancer: correlation with histological expression of ICAM-1 and tumour stage

Grothey¹,

Heistermann²,

Philippou³

et al. 1998

Br J Cancer

View full text Add to dashboard Cite

Summary The expression of the intercellular adhesion molecule-1 (ICAM-1, CD54) seems to have an influence on the metastatic behaviour of tumour cells via immunological mechanisms. Recently, a soluble form of ICAM-1 was identified in physiological fluids. We analysed the serum levels of sICAM-1 in patients with non-small-cell lung cancer (NSCLC) and healthy individuals using a sandwich ELISA technique. Sera from 51 patients with NSCLC were tested for sICAM-1 (46 male, five female; age 38-81 years, median 64 years), 29 of whom presented with localized and 26 with metastatic disease. The control group consisted of 40 healthy individuals (20 smokers, 20 non-smokers). Immunohistochemical analysis of ICAM-1 in tumour cells was performed in 20 cases. Patients with NSCLC had significantly higher serum levels of sICAM-1 compared with healthy non-smokers (P = 0.00001) and smokers (P = 0.0328). Metastatic disease was associated with higher sICAM-1 than localized tumours (P = 0.0013). Only 11 out of 23 patients with localized NSCLC had sICAM-1 levels >300 ng ml-1, compared with 25 out of 28 patients with metastatic disease. Histological expression of ICAM-1 was positively correlated with serum sICAM-1 (P = 0.0399). No difference was observed between histological tumour types with regard to sICAM-1 or NSCLC expression of ICAM-1. In sequential analysis (13 patients), rising sICAM-1 levels predicted a short-term fatal outcome (P = 0.0054) but, overall, sICAM-1 levels did not correlate with prognosis. In the control group, smokers showed significantly higher levels than non-smokers (P = 0.0016). In contrast to patients with NSCLC, sICAM-1 in the control group was correlated to the leucocyte count (r = 0.580, P = 0.003). In conclusion, serum levels of sICAM-1 seem to be associated with tumour burden and histological expression of ICAM-1 in patients with NSCLC. However, the (patho-) physiological role of ICAM-1 in NSCLC remains to be determined.

show abstract

Section: Discussionmentioning

confidence: 95%

Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1, CD54) in patients with non-small-cell lung cancer: correlation with histological expression of ICAM-1 and tumour stage

Grothey¹,

Heistermann²,

Philippou³

et al. 1998

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…16,18 Furman et al 27 examined the association between WBC count and mortality using data from the Worcester Heart Attack Study. Consistent with the findings from our study, these investigators found that WBC count was significantly associated with in-hospital survival.…”

Section: Wbc Count and Crp In Acute Myocardial Infarctionmentioning

confidence: 99%

White Blood Cell Count and C-reactive Protein Predict Short-term Prognosis in Acute Myocardial Infarction

Keskin¹,

Ulusoy²,

Kalemoğlu³

et al. 2004

J Int Med Res

View full text Add to dashboard Cite

An elevated white blood cell (WBC) count and C-reactive protein (CRP) concentration are associated with acute myocardial infarction (AMI) and long-term mortality in patients with coronary artery disease. Their relationship with short-term prognosis following AMI is less clear, however. We investigated the relationship between WBC count and CRP concentration, obtained at the time of admission, and the development of subsequent ischaemic coronary events (SICE) within 30 days of AMI in 177 patients. After adjustment for confounding factors, CRP concentration was found to be a strong independent predictor for SICE within 30 days in patients with AMI. WBC count was not found to be an independent predictor, but there was a strong correlation between high WBC counts and the onset of SICE within 30 days in patients with AMI. We conclude that CRP concentration and WBC count could be used to predict the short-term prognosis of patients with AMI.

show abstract

“…1 Different markers of inflammation, including C-reactive protein, interleukin-6, erythrocyte sedimentation rate, fibrinogen, and other acute phase proteins have been associated with coronary events (CEs). [2][3][4][5][6] Increased leukocyte count is a classic marker of chronic and acute inflammation, reflecting proliferation and recruitment of leukocytes to the vascular system. Elevated leukocyte concentrations have been associated with increased incidence of myocardial infarction and stroke.…”

mentioning

confidence: 99%

“…8,14 Approximately 30% of men who experience a first acute CE die within the first days, and most of them die suddenly without reaching the hospital. 15 Elevated concentrations of leukocytes have been associated with worse prognosis in subjects with clinically manifest CHD, 5 but there are limited data from population-based studies of case fatality, including cases who died out-of-hospital. It was reported that 5 acute phase proteins were associated with increased fatality in men who experienced a CE, 16 but it remains unknown whether raised concentrations of leukocytes affect the fatality of subsequent CEs.…”

mentioning

confidence: 99%

Incidence of Coronary Events and Case Fatality Rate in Relation to Blood Lymphocyte and Neutrophil Counts

Eryd

Smith

Melander

et al. 2012

ATVB

View full text Add to dashboard Cite

Objective-Elevated levels of blood leukocytes have been associated with acute coronary events (CEs), but data on leukocyte subclasses are limited. This study aimed to explore whether blood lymphocyte and neutrophil counts are associated with incidence of CEs and with fatal outcome in subjects who subsequently experienced a first CE. Methods and Results-Neutrophil and lymphocyte counts were measured in 27 419 subjects from the general population without a history of CEs, heart failure, or atrial fibrillation. Incidence of CEs was studied in relation to leukocyte counts during a mean follow-up of 13.6 years. Neutrophil but not lymphocyte counts were significantly associated with incidence of CEs. After adjustments for confounding factors, the hazard ratios (95% confidence interval) were 1.00 (reference), 1.07 (0.94 -1.23), 1.09 (0.95-1.25), and 1.39 (1.22-1.59) for subjects with neutrophils in the first, second, third, and fourth (highest) sex-specific quartiles, respectively (P for trend Ͻ0.001). Of the 1965 subject who had a CE, 471 subjects died on the first day of the CE, in-or outside hospital. The proportions of subjects who died the first day were 19%, 21%, 25%, and 28%, respectively in the first, second, third, and fourth quartiles (P for trend Ͻ0.001). Conclusion-Increased neutrophil counts are associated with incidence of CEs and increased case-fatality rate after a CE.(Arterioscler Thromb Vasc Biol. 2012;32:533-539.)

show abstract

White Blood Cell Count and Haematocrit as Predictors of Coronary Recurrence after Myocardial Infarction

Cited by 109 publications

References 29 publications

Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1, CD54) in patients with non-small-cell lung cancer: correlation with histological expression of ICAM-1 and tumour stage

Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1, CD54) in patients with non-small-cell lung cancer: correlation with histological expression of ICAM-1 and tumour stage

White Blood Cell Count and C-reactive Protein Predict Short-term Prognosis in Acute Myocardial Infarction

Incidence of Coronary Events and Case Fatality Rate in Relation to Blood Lymphocyte and Neutrophil Counts

Contact Info

Product

Resources

About