White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate

Monk, Jennifer M.; Zhang, Claire P.; Wu, Wenqing; Zarepoor, Leila; Lu, Jenifer T.; Liu, Ronghua; Pauls, K. Peter; Wood, Geoffrey A.; Tsao, Rong; Robinson, Lindsay E.; Power, Krista A.

doi:10.1016/j.jnutbio.2015.02.003

Cited by 55 publications

(60 citation statements)

References 91 publications

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“…Our study shows that supplementation of GP accelerated the recovery from colitis symptoms in the HFD-fed mice as evident from decreased body weight loss and a lower fecal blood score during the recovery stage. In support of our findings, supplementation of dietary white and dark kidney beans as well as cranberry beans reduced colitis severity by reducing body weight loss, fecal blood score, and resultant DAI score in DSS-induced colitis mice [15,16]. Similarly, dietary supplementation of soybeans Bowman–Birk inhibitor concentrate reduced the severity of DSS-colitis by suppressing inflammation in the colon and improving the recovery following DSS-induction [14].…”

Section: Discussionsupporting

confidence: 66%

“…In the current study, elevated levels of IL-6, IL-17, IFN-γ, iNOS, and COX-2 caused by DSS-induction were ameliorated by GP supplementation in the colon of HFD-fed mice. Consistently, dietary white and dark kidney beans reduced the mRNA expression of IL-6 [15], and cranberry bean supplementation reduced the IL-6 protein in the colon along with reduced serum IL-6, IL-17, and IFN-γ in DSS-induced colitis [16]. The down-regulation of inflammatory cascades and oxidative stress by GP supplementation can be partially explained by the low neutrophil infiltration into the colon of HFD-fed DSS-colitis mice.…”

Section: Discussionmentioning

confidence: 96%

“…In agreement, the current study found that DSS-induction enhanced both the neutrophil infiltration and MCP-1 expression in the colon of HFD-fed mice, which were mitigated by GP supplementation. Inline, dietary white and dark kidney beans, as well as cranberry bean supplements, reduced the mRNA expression of MCP-1 in the colon of DSS-colitis mice [15,16]. …”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, dietary chickpea supplementation increased colon mucus content, mRNA expression of MUC-2, and differentiation marker Klf4 with enhanced gut barrier integrity and reduced inflammation in healthy unchallenged mice [13]. In DSS-induced colitis, dietary white and dark kidney beans, as well as dietary cranberry bean supplementation, enhanced the mRNA expression of MUC-2 and Tff3, and mitigated the severity of colitis and associated inflammation [15,16]. Consistent with these observations as well as improved colitis symptoms, GP supplementation improved both protein and gene expression of MUC-2 in HFD-fed DSS-induced mice, associated with the enhanced expression of goblet cell differentiation markers in the colon.…”

Section: Discussionmentioning

confidence: 99%

“…Legumes and pulses, including peas, are rich in fiber and other phytonutrients that boost beneficial intestinal microbiota [12], producing short chain fatty acids (SCFA) and promoting epithelial barrier integrity [13]. Further, dietary soybean Bowman–Birk inhibitor concentrate [14], white and dark kidney beans [15], and cranberry bean supplements [16] suppressed colonic inflammation and reduced the severity of DSS-induced colitis in mice. Consistently, pea seed albumin extract ameliorated DSS-induced colitis in mice by reducing the expression of inflammatory markers in colonic tissues [17].…”

Section: Introductionmentioning

confidence: 99%

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Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet

et al. 2017

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Obesity is a risk factor for developing inflammatory bowel disease. Pea is unique with its high content of dietary fiber, polyphenolics, and glycoproteins, all of which are known to be health beneficial. We aimed to investigate the impact of green pea (GP) supplementation on the susceptibility of high-fat diet (HFD)-fed mice to dextran sulfate sodium (DSS)-induced colitis. Six-week-old C57BL/6J female mice were fed a 45% HFD or HFD supplemented with 10% GP. After 7-week dietary supplementation, colitis was induced by adding 2.5% DSS in drinking water for 7 days followed by a 7-day recovery period. GP supplementation ameliorated the disease activity index score in HFD-fed mice during the recovery stage, and reduced neutrophil infiltration, mRNA expression of monocyte chemoattractant protein-1 (MCP-1) and inflammatory markers interleukin (IL)-6, cyclooxygenase-2 (COX-2), IL-17, interferon-γ (IFN-γ), and inducible nitric oxide synthase (iNOS) in HFD-fed mice. Further, GP supplementation increased mucin 2 content and mRNA expression of goblet cell differentiation markers including Trefoil factor 3 (Tff3), Krüppel-like factor 4 (Klf4), and SAM pointed domain ETS factor 1 (Spdef1) in HFD-fed mice. In addition, GP ameliorated endoplasmic reticulum (ER) stress as indicated by the reduced expression of Activating transcription factor-6 (ATF-6) protein and its target genes chaperone protein glucose-regulated protein 78 (Grp78), the CCAAT-enhancer-binding protein homologous protein (CHOP), the ER degradation-enhancing α-mannosidase-like 1 protein (Edem1), and the X-box binding protein 1 (Xbp1) in HFD-fed mice. In conclusion, GP supplementation ameliorated the severity of DSS-induced colitis in HFD-fed mice, which was associated with the suppression of inflammation, mucin depletion, and ER stress in the colon.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet

et al. 2017

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Compositional, morphological, and physicochemical properties of starches from red adzuki bean, chickpea, faba bean, and baiyue bean grown in China

Zuo-sheng

Tian

Wang

et al. 2019

Food Science & Nutrition

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Starches of four legume varieties grown in China were evaluated for composition, granule structure, turbidity, swelling power, solubility, and thermal and pasting properties. The similar granule shapes, surface fissures, polarized crosses, inner structure characteristics, and granule sizes could be observed among all legume varieties through a variety of microscopy techniques such as light microscopy, scanning electron microscopy, and confocal laser scanning microscopy. Amylose contents were in the range of 30.61%–33.55%. All of the starch varieties showed C‐type X‐ray pattern, but exhibited different relative crystallinity percentage. Significant differences were observed among starch varieties in swelling power, solubility, and light transmittance. Thermal analysis and pasting profile of legume starches showed that all the varieties’ differences are probably due to variation in amylose content. The thermal and pasting parameters of starches were evaluated using differential scanning calorimeter and Rapid Visco‐Analyser, respectively, and significant differences were observed in individual pasting and thermal parameters. The present study can be used for identifying differences between legume varieties for starch structural and physicochemical characteristics and could provide guidance to possible industries for their end use.

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Inclusion of limited amounts of extruded legumes plus cereal mixes in normocaloric or obesogenic diets for rats: effects on intestinal microbiota composition

et al. 2020

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BACKGROUND: Differences in the composition of the intestinal microbiota and energetic metabolism between lean and obese populations have been described. Legume consumption has been reported to modulate intestinal microbiota composition. However, to the best of our knowledge, no information can be found in the literature on the effects of consumption of diets containing extruded legume plus cereal mixes on the intestinal microbiota composition of rats. Our purpose was to evaluate the effects on lipids profile (see the accompanying paper) and intestinal microbiota composition (current paper) of incorporating this new food ingredient in normocaloric and obesogenic diets. RESULTS: Intestinal and fecal qPCR-based microbial composition of rats fed the extruded legumes plus cereal mixes differed (P < 0.05) from controls. Obesogenic diets did not affect bacterial counts. However, the inclusion of the extruded mixes reduced (P < 0.05) log 10 counts in some bacterial groups and increased (P < 0.05) counts of Lactobacilli, while others remained unaffected. PCoA at the genus level grouped together Lactobacillus reuteri, Akkermansia miciniphila and species from Parabacteroides, Prevotella, Rikenellaceae, and Lactobacillus with extruded legume plus cereal diets. Feeding on extruded legumes plus cereal mixes was associated with increased mRNA expression of the cytokines IL6 and TNF-⊍ and decreased expression of TLR4. CONCLUSIONS: Our results show that the inclusion in the feed of limited amounts of extruded legumes plus cereal mix, providing a diet that is closer to a normal human one, did modulate the intestinal microbiota composition. Taken together, these results point to the protective, health-promoting properties of extruded legume plus cereal mixes.

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White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate

Cited by 55 publications

References 91 publications

Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet

Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet

Compositional, morphological, and physicochemical properties of starches from red adzuki bean, chickpea, faba bean, and baiyue bean grown in China

Inclusion of limited amounts of extruded legumes plus cereal mixes in normocaloric or obesogenic diets for rats: effects on intestinal microbiota composition

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