Whipple’s Disease: An Endoscopic and Histologic Study

Mönkemüller, Klaus; Fry, Lucía C.; Arnim, Ulrike von; Neumann, Helmut; Evert, Matthias; Malfertheiner, Peter

doi:10.1159/000140978

Cited by 17 publications

(16 citation statements)

References 31 publications

(78 reference statements)

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“…Whipple's disease has a wide range of endoscopic features such as brown discoloration of the mucosa, erythematous spots, subepithelial hemorrhages and megaduodenum. Features on magnification endoscopy include engorged and flattened villi, villi filled with white material, white ring-like structures inside of the villi and multiple yellow spots [51]. Histologically, small intestinal biopsies reveal foamy macrophages containing periodic-acid-Schiff-positive materials [52].…”

Section: Associated Conditionsmentioning

confidence: 99%

Mesenteric panniculitis: an update

Hussein¹,

Abdelwahed²

2014

Expert Review of Gastroenterology & Hepatology

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In 1924, mesenteric panniculitis was first described in the medical literature by Jura et al. as 'retractile mesenteritis.' It represents a spectrum of disease processes characterized by degeneration, inflammation and scarring of the adipose tissue of the mesentery. The clinical presentations vary according to the stage of the disease and they include abdominal pain, weight loss, nausea and vomiting. Computed tomography findings are usually diagnostic. The gross findings include thickening of the mesentery, mass lesions and adhesion to the surrounding organs. Histologically, there is a chronic inflammatory process involving the adipose tissue with fat necrosis, inflammation and fibrosis. Herein, the authors address the clinicopathological features, course, treatment and pathogenetic mechanisms of mesenteric panniculitis.

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Section: Associated Conditionsmentioning

confidence: 99%

Mesenteric panniculitis: an update

Hussein¹,

Abdelwahed²

2014

Expert Review of Gastroenterology & Hepatology

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“…White‐light endoscopy revealed pale yellow, shaggy mucosa with intermittent, superficial, erythematous eroded patches of the duodenum, whereas i‐scan additionally revealed edematous and engorged duodenal villi filled with a white material representing lymph. Moreover, concentric rings of the mucosa were visible, which have been identified to be specific for Whipple's disease in previous studies using optical magnification endoscopy with 115‐fold magnification …”

Section: Present Applications Of I‐scan Technology For Duodenal Pathomentioning

confidence: 77%

Present and future perspectives of virtual chromoendoscopy with i‐scan and optical enhancement technology

Neumann

Fujishiro

Wilcox

et al. 2013

Digestive Endoscopy

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Despite being the current gold standard, white-light endoscopy may miss a significant proportion of lesions within the colorectum, thus leading to a misinterpretation of various disease findings. Traditionally, dye-based chromoendoscopy is used to improve both detection and characterization of lesions during luminal gastrointestinal (GI) endoscopy. Recently introduced dyeless chromoendoscopy (DLC) techniques have overcome many of the limitations of dye-based chromoendoscopy, thereby potentially improving lesion recognition and characterization. In detail, DLC techniques allow for better detection of esophageal lesions, gastric cancer and colorectal pathologies including colorectal polyps and inflammatory bowel diseases. Moreover, DLC techniques enable a more precise characterization of lesions throughout the whole luminal GI tract, thereby potentially enabling more accurate endoscopic therapies. In the present review we focus on the newly introduced dye-less chromoendoscopy technique i-scan and give an additional outlook on the recent development of optical enhancement technology.

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“…Manifestna faza se karakteriše simptomima koji zavise od zahva enog organskog sistema 9 . Gastrointestinalni trakt je zahva en kod jedne tre ine bolesnika 10,11 . Dominiraju simptomi malapsorpcije (proliv, nadimanje), kao i bolovi u trbuhu [12][13][14] .…”

Section: Diskusijaunclassified

“…Ova tehnika se može sprovoditi na bilo kom tkivu, krvi ili sekretu 19,20 . Primenom drugih imaging tehnika za evaluaciju tankog creva (pasaža, enterokliza) vide se nespecifi ni znaci malapsorpcije, kao i zadebljanje mukoznih nabora, naro ito u duodenumu i proksimalnom jejunumu 10 . Kod opisanog bolesnika, nalaz pasaže tankog creva ukazao je na diskretno izraženije Kerkingove nabore i reljef sluznice tankog creva, ali tipi ni radiografski znaci malapsorpcije nisu vi eni.…”

Section: Diskusijaunclassified