Whipple disease in a patient under anti-TNFα therapy

Estévez-Gil, Melania; Castro-Parga, Maria Luisa de; Carballo-Fernandez, Carmen; Martín-Alonso, Mario San; Machado-Prieto, Begoña; Cid-Gómez, Lucia Amelia; Caride-López, Gloria

doi:10.1016/j.gastre.2016.02.008

Cited by 1 publication

(2 citation statements)

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“…Deformations of the spine are rare. Nonsteroidal antirheumatic drugs are ineffective and administration of TNFα inhibitors usu ally aggravated the disease and facilitated making the WD diagnosis [40][41][42][43][44]. It is of note that Tropheryma whipplei can cause uveitis, a common extraarticular manifestation of inflammatory spondyloarthropathy [45] (Table I).…”

Section: Musculoskeletal Manifestationsmentioning

confidence: 99%

“…Reported cases suggested association of initiation of immunosuppres sion with onset of diarrhea and subsequent diagnosis of WD. TNFα inhibitors have been shown to result in fatal exacerbation of the disease [40][41][42][43][44]. Previous immuno suppressive therapy can be associated with the develop ment of immune reconstitution inflammatory syndrome in patients with WD.…”

Section: Treatmentmentioning

confidence: 99%

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Clinical manifestations of Whipple’s disease mimicking rheumatic disorders

Kucharz¹,

Kramza²,

Grosicka³

et al. 2021

Reumatologia

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Whipple’s disease is a rare, chronic, systemic disorder caused by Tropheryma whipplei infection. The most common symptoms are weight loss, arthralgia, diarrhea and abdominal pain. Other organ involvement can also occur in the patients. Joint manifestations may mimic rheumatoid arthritis or spondyloarthritis. Arthalgia, arthritis, spondylodiscitis, bursitis and/or tenosynovitis are seen in the majority of the patients. This explains why some of the symptoms are misdiagnosed as those of rheumatic diseases. Understanding of Whipple’s disease is important for differential diagnostics of several rheumatic symptoms.

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