Which Obesity Index Best Correlates With Prostate Volume, Prostate-specific Antigen, and Lower Urinary Tract Symptoms?

Yang, Hee Jo; Doo, Seung Whan; Yang, Won Jae; Song, Yun Seob

doi:10.1016/j.urology.2012.04.003

Cited by 29 publications

(19 citation statements)

References 27 publications

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“…A recent growing body of evidence suggests that obese men may have lower serum PSA, 2-13 mainly due to a haemodilution effect. In contrast, obesity has been positively correlated with PV in multiple study populations [10][11][12][13] and it is well known that a larger PV is associated with a higher serum PSA level. Therefore, obesity has conflicting influences on serum PSA level.…”

Section: Discussionmentioning

confidence: 96%

Association between obesity, prostate-specific antigen level and prostate-specific antigen density in men with a negative prostate biopsy

et al. 2014

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Objective: To determine the association between body mass index (BMI), serum prostate-specific antigen (PSA) level and PSA density (PSAD) in patients with an elevated serum PSA level but a negative prostate biopsy. Methods: This retrospective study enrolled men with a negative prostate biopsy but a serum PSA level of 3.0-10 ng/ml. All men underwent anthropometric measurements, serum PSA determination and transrectal ultrasound examination. BMI was grouped according to the Asia-Pacific obesity criteria: nonobese (<25 kg/m 2 ) versus obese (!25 kg/m 2 ). Partial correlation and linear regression models between PSA, PSAD and BMI were conducted after adjusting for age. Results: A total of 907 men were enrolled in this study. On multivariate analyses, PSA showed no significant correlation with age or BMI, whereas PSAD had a negative correlation with age and BMI. Similar results were obtained when patients were categorized as having low (3.0 < PSA 6.5 ng/ml) or high PSA (6.5 < PSA 10.0 ng/ml) levels. Conclusion: PSAD, but not PSA, demonstrated a significant negative correlation with BMI. This indicates that a new strategy including PSAD rather than simple PSA levels should be adopted in the study of obesity-adjusted PSA cut-offs.

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Section: Discussionmentioning

confidence: 96%

Association between obesity, prostate-specific antigen level and prostate-specific antigen density in men with a negative prostate biopsy

et al. 2014

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“…The cause of a positive relationship between PSA and age is that prostate volume increases with age, thus the production content of PSA in prostate tissue increases (20). Moreover, a study, conducted by Yang et al, showed that there was a positive relationship between central obesity and prostate volume, also there was a negative relationship between serum PSA level and an increase in BMI (7). Accordingly, in a study, conducted by Ahn et al, a negative relationship between serum PSA level and BMI was observed, and age in this group which includes 20-39 years people, did not show a relationship with serum PSA level (6).…”

Section: Discussionmentioning

confidence: 99%

Prostate-specific antigen rising in Iranian men in correlation with body mass index, fasting blood sugar and blood lipid profile

Arab¹,

Zadeh²,

Mirmohammadkhani³

et al. 2016

J Nephropathol

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Background Prostate-specific antigen (PSA) is a serine protease that is secreted by prostate cells and it is useful as a tumor marker for prostate cancer. Objectives In this study, the relationship between some of metabolic factors and serum PSA level was investigated. Materials and Methods In this cross-sectional study, patients with urinary symptoms or for screening of the prostate cancer (after 50 years of age or 40 years with a family history of prostate cancer), were evaluated. Collected data included metabolic syndrome factors such as cholesterol (Chol), triglycerides (TG), fasting blood sugar (FBS), and body mass index (BMI), serum PSA level, prostate volume and age. Results 481 patients were enrolled to this study with the average age of 60.69 ± 9.72 years and the average PSA level of 1.70 ng/ml. Data analysis showed that there was a significant relationship between serum PSA level with age (P < 0.001, r = 0.30) and prostate volume (P < 0.001, r = 0.29). There were not significant relationship between serum PSA level with TG (P = 0.57, r = 0.026), Chol (P = 0.57, r = -0.025), FBS (P = 0.054, r = 0.088), and BMI (P = 0.89, r = 0.006). Conclusions This study showed that, with increasing age and prostate volume, serum PSA level increased, and an increase in the levels of cholesterol, TG, FBS and BMI did not have significant effect on serum PSA level.

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“…In men, lower urinary tract symptoms were greatly affected by prostates. Previous studies showed conflicting results with regard to the impact of obesity on prostate volume . Therefore, we chose CKD male patients under 50 to eliminate the effects of prostates on lower urinary tract symptoms.…”

Section: Discussionmentioning

confidence: 99%

Are Middle‐Aged Men with Chronic Kidney Disease at Higher Risk of Having Nocturia than Age‐Matched Controls

Hsu

Chiang

et al. 2014

LUTS

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Which Obesity Index Best Correlates With Prostate Volume, Prostate-specific Antigen, and Lower Urinary Tract Symptoms?

Cited by 29 publications

References 27 publications

Association between obesity, prostate-specific antigen level and prostate-specific antigen density in men with a negative prostate biopsy

Association between obesity, prostate-specific antigen level and prostate-specific antigen density in men with a negative prostate biopsy

Prostate-specific antigen rising in Iranian men in correlation with body mass index, fasting blood sugar and blood lipid profile

Are Middle‐Aged Men with Chronic Kidney Disease at Higher Risk of Having Nocturia than Age‐Matched Controls

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