Which NK cell populations mark the high burden of CMV present in all HIV patients beginning ART in Indonesia?

Ariyanto, Ibnu; Estiasari, Riwanti; Karim, Birry; Wijaya, Ika Praseya; Bela, Budiman; Soebandrio, Amin; Price, Patricia; Lee, Silvia

doi:10.1186/s12981-022-00439-2

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…In the paper of Ariyanto, the levels of CMV antibody increased on ART [19]. In our study, ART has no statistical correlation with IgG CMV values, but there is a positive correlation (r(48) = 0.024) between the two variables as stated in Ariyanto's study as well.…”

Section: Discussionsupporting

confidence: 51%

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CMV and HIV Coinfection in Women from a Region in Eastern Europe

Halichidis,

Aschie,

Cozaru

et al. 2023

JPM

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(1) Background: Human cytomegalovirus (CMV) infection is one of the most frequent opportunistic infections in immunosuppressed patients. Romania has one of the highest incidences of patients living with human immunodeficiency virus (HIV) which determines an immunosuppressive state. The aim of this study was to establish the prevalence of CMV infection among women living with HIV in Southeastern Romania and also to evaluate and correlate antiretroviral therapy (ART) with CD4 level and CMV disease evolution. (2) Methods: Seventy women living with HIV from Southeastern Romania were screened for CMV infection using antigen quantification. Of these, 50 were included in the study. First, the patients filled out a questionnaire regarding social conditions and other associated diseases. Then, we explored the statistical correlations between the data and HIV status, CD4+ cell counts, viral load, and antiretroviral therapy (ART). (3) Results: Median age of the patients was 33 years. Twenty-nine cases were diagnosed with HIV after sexual life beginning and 21 before. Most of the patients had a CD4 level over 200 cells/µL. ART duration in the CD4 under 200 cells/µL group was a bit longer than that in the CD4 over 200 cells/µL group. Forty-one patients had undetectable viremia. CD4 average value in the lot of patients with undetectable viremia was 704.71 cells/µL and in the lot with detectable viremia was 452.44 cells/µL. Viremia values correlated negatively with CD4 level. A positive correlation between IgG CMV values and ART therapy length was identified. A negative significant correlation between values of IgG CMV and values of CD4 was identified. CD4 value correlated negatively with IgG CMV values and with CMV avidity. (4) Conclusions: IgG CMV values had a weak positive correlation with ART therapy length, and a negative statistically significant correlation with values of CD4. CMV avidity has a negative correlation with CD4 value.

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Section: Discussionsupporting

confidence: 51%

“…The youngest age at HIV diagnosis was 3 years old. The oldest age at HIV diagnosis was 63 years old (the patient is from the urban area, with one declared sexual partner and beginning of sexual life after age 19). Median age at HIV diagnosis is 18.82 years.…”

Section: Socio-demographic Characterization Of the Patientsmentioning

confidence: 99%

CMV and HIV Coinfection in Women from a Region in Eastern Europe

Halichidis,

Aschie,

Cozaru

et al. 2023

JPM

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Human Cytomegalovirus Infection and Cardiovascular Disease: Current Perspectives

et al. 2023

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Adaptive NK Cells Rapidly Expand during Acute HIV Infection and Persist Despite Early Initiation of Antiretroviral Therapy

Hearps,

Zhou,

Agius

et al. 2024

The Journal of Immunology

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HIV is associated with NK cell dysfunction and expansion of adaptive-like NK cells that persist despite antiretroviral therapy (ART). We investigated the timing of NK cell perturbations during acute HIV infection and the impact of early ART initiation. PBMCs and plasma were obtained from people with HIV (PWH; all men who have sex with men; median age, 26.0 y) diagnosed during Fiebig stages I, II, III, or IV/V. Participants initiated ART a median of 3 d after diagnosis, and immunophenotyping was performed at diagnosis and longitudinally after ART. Anti-CMV Abs were assessed by ELISA. Samples from matched HIV-uninfected males were also analyzed. Proportions of adaptive NK cells (A-NKs; defined as Fcε-Receptor-1γ–) were expanded at HIV diagnosis at all Fiebig stages (pooled median 66% versus 25% for controls; p < 0.001) and were not altered by early ART initiation. Abs to CMV immediate early protein were elevated in PWH diagnosed in Fiebig stages III and IV/V (p < 0.03 for both). Proportions of A-NKs defined as either Fcε-Receptor-1γ− or NKG2C+/CD57+ were significantly associated with HIV DNA levels at diagnosis (p = 0.046 and 0.029, respectively) and trended toward an association after 48 wk of ART. Proportions of activated HLA-DR+/CD38+ NK cells remained elevated in PWH despite early ART initiation. NK cell activation and A-NK expansion occur very early after HIV transmission, before T cell activation, and are not altered by ART initiation during acute infection. A-NKs may contribute to HIV control and thus be useful for HIV cure.

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Which NK cell populations mark the high burden of CMV present in all HIV patients beginning ART in Indonesia?

Cited by 3 publications

References 26 publications

CMV and HIV Coinfection in Women from a Region in Eastern Europe

CMV and HIV Coinfection in Women from a Region in Eastern Europe

Human Cytomegalovirus Infection and Cardiovascular Disease: Current Perspectives

Adaptive NK Cells Rapidly Expand during Acute HIV Infection and Persist Despite Early Initiation of Antiretroviral Therapy

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