Which Is the Most Suitable Classification for Colorectal Cancer, Log Odds, the Number or the Ratio of Positive Lymph Nodes?

Abstract

ObjectiveThe aim of the current study was to investigate which is the most suitable classification for colorectal cancer, log odds of positive lymph nodes (LODDS) classification or the classifications based on the number of positive lymph nodes (pN) and positive lymph node ratio(LNR) in a Chinese single institutional population.DesignClinicopathologic and prognostic data of 1297 patients with colorectal cancer were retrospectively studied. The log-rank statistics, Cox's proportional hazards model, the Nagelkerke R2 index and a Harrell's C statistic were used.ResultsUnivariate and three-step multivariate analyses identified that LNR was a significant prognostic factor and LNR classification was superior to both the pN and LODDS classifications. Moreover, the results of the Nagelkerke R2 index (0.130) and a Harrell's C statistic (0.707) of LNR showed that LNR and LODDS classifications were similar and LNR was a little better than the other two classifications. Furthermore, for patients in each LNR classification, prognosis was homologous between those in different pN or LODDS classifications. However, for patients in pN1a, pN1b, LODDS2 and LODDS3 classifications, significant differences in survival were observed among patients in different LNR classifications.ConclusionsFor patients with colorectal cancer, the LNR classification is more suitable than pN and LODDS classifications for prognostic assessment in a Chinese single institutional population.

Impact of Lymph Node Ratio on the Survival of Patients with Hypopharyngeal Squamous Cell Carcinoma: A Population-Based Analysis

“…The lymph node ratio (LNR), defined as the number of involved nodes divided by the number of lymph nodes examined, was found to improve prognostic information in breast cancer, gastric cancer, colorectal cancer, melanoma and others. [6], [7], [8], [9], [10], [11], [12] Approximately 60% to 80% of patients with hypopharyngeal cancer have locally advanced disease with spread to regional nodes at diagnosis. [13] However, there have been no previous studies on the impact of the LNR on predicting the prognosis of hypopharyngeal cancer.…”

Log odds of positive lymph nodes is superior to the number- and ratio-based lymph node classification systems for colorectal cancer patients undergoing curative (R0) resection

“…In the present study, the LODDS classification was found to be superior to the pN and LNR classifications in Chinese patients with CRC undergoing R0 curative resection for the first time. Song et al (32) revealed that, for Chinese patients with CRC, the LNR classification was more suitable compared with the pN and LODDS classifications for prognostic assessment. Several reasons may have contributed to these different results: i) The cut-off points acquired from different statistical methods for subclassification were different; ii) the proportion of colon and rectal cancer patients was different; and iii) the time interval between the date of the last patient undergoing curative resection to the follow-up deadline (October, 2015) was different.…”

Survival effect of different lymph node staging methods on ovarian cancer: An analysis of 10 878 patients

“…Therefore, increasing attention has been paid to lymph node status, which can be evaluated by the number of resected lymph nodes (RLNs), lymph node ratio (LNR), and the log odds of positive lymph nodes (LODDS) . Compared to a single parameter, LNR exhibits its advantage in breast, pancreatic, colon, and ovarian cancers.…”

“…Compared to a single parameter, LNR exhibits its advantage in breast, pancreatic, colon, and ovarian cancers. Another parameter, LODDS, showed superiority in predicting outcomes in breast, pancreatic, colorectal, and ovarian cancers.…”