Which are the Best Biological Markers of the Antiphospholipid Syndrome?

Carreras, L; Forastiero, Ricardo; Martinuzzo, Marta

doi:10.1006/jaut.2000.0401

Cited by 71 publications

(51 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is noteworthy that autoimmune Ab's of the IgG isotype, as found in the RE patients, are found characteristically only in patients at the progressive stages of the respective autoimmune disease, often in good correlation with the clinical status of the patients (e.g. see Carreras et al (2000)). …”

Section: Insulin-dependent Diabetes Mellitus (Iddm) Stiff-person Synmentioning

confidence: 91%

Autoimmune Epilepsy: Some Epilepsy Patients Harbor Autoantibodies to Glutamate Receptors and dsDNA on both Sides of the Blood‐brain Barrier, which may Kill Neurons and Decrease in Brain Fluids after Hemispherotomy

Ganor

Goldberg‐Stern

Amrom³

et al. 2004

Journal of Immunology Research

View full text Add to dashboard Cite

Purpose: Elucidating the potential contribution of specific autoantibodies (Ab's) to the etiology and/or pathology of some human epilepsies. Methods: Six epilepsy patients with Rasmussen's encephalitis (RE) and 71 patients with other epilepsies were tested for Ab's to the "B" peptide (amino acids 372-395) of the glutamate/AMPA subtype 3 receptor (GluR3B peptide), double-stranded DNA (dsDNA), and additional autoimmune disease-associated autoantigens, and for the ability of their serum and cerebrospinal-fluid (CSF) to kill neurons. Results: Elevated anti-GluR3B Ab's were found in serum and CSF of most RE patients, and in serum of 17/71 (24%) patients with other epilepsies. In two RE patients, anti-GluR3B Ab's decreased drastically in CSF following functional-hemispherotomy, in association with seizure cessation and neurological improvement. Serum and CSF of two RE patients, and serum of 12/71 (17%) patients with other epilepsies, contained elevated anti-dsDNA Ab's, the hallmark of systemic-lupus-erythematosus. The sera (but not the CSF) of some RE patients contained also clinically elevated levels of "classical" autoimmune Ab's to glutamic-acid-decarboxylase, cardiolipin, b2-glycoprotein-I and nuclear-antigens SS-A and RNP-70. Sera and CSF of some RE patients caused substantial death of hippocampal neurons. Conclusions: Some epilepsy patients harbor Ab's to GluR3 and dsDNA on both sides of the bloodbrain barrier, and additional autoimmune Ab's only in serum. Since all these Ab's may be detrimental to the nervous system and/or peripheral organs, we recommend testing for their presence in epilepsy, and silencing their activity in Ab-positive patients.

show abstract

Section: Insulin-dependent Diabetes Mellitus (Iddm) Stiff-person Synmentioning

confidence: 91%

Autoimmune Epilepsy: Some Epilepsy Patients Harbor Autoantibodies to Glutamate Receptors and dsDNA on both Sides of the Blood‐brain Barrier, which may Kill Neurons and Decrease in Brain Fluids after Hemispherotomy

Ganor

Goldberg‐Stern

Amrom³

et al. 2004

Journal of Immunology Research

View full text Add to dashboard Cite

show abstract

“…However, aPL have also been shown to bind antigens such as prothrombin, annexin V, and ␤ 2 -glycoprotein I (␤ 2 GPI). Antibodies reacting with these antigens may be directly involved in the pathogenesis of aPL-associated symptoms (16)(17)(18)(19)(20)(21).…”

mentioning

confidence: 99%

The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus

McClain¹,

Arbuckle²,

Heinlen³

et al. 2004

Arthritis & Rheumatism

171

126

View full text Add to dashboard Cite

Objective. To determine whether antiphospholipid antibodies (aPL) occur before the diagnosis of systemic lupus erythematosus (SLE) and before initial clotting events, and whether their presence early in the disease course influences clinical outcome.Methods. Serum samples obtained from 130 lupus patients before and after SLE diagnosis were screened for IgG and IgM aPL using an anticardiolipin (aCL) enzyme-linked immunosorbent assay. Medical records of all patients were carefully reviewed for data on the time of onset of SLE features meeting clinical criteria and on disease manifestations.Results. Twenty-four patients (18.5%) were positive for IgG and/or IgM aCL prior to SLE diagnosis. Anticardiolipin antibodies appeared from 7.6 years prior to SLE diagnosis to within the same month as SLE diagnosis, with a mean onset occurring 3.0 years before SLE diagnosis. Additionally, aCL presence early in the disease process seemed to predict a more severe clinical outcome; these patients eventually met an average of 6.1 of the 11 classification criteria for SLE, compared with 4.9 criteria for other patients (P < 0.001). The early aCL-positive population also had more frequent renal disease, central nervous system disease, thrombocytopenia, and clotting events. In this population, aCL preceded initial thrombotic events by a mean of 3.1 years.Conclusion. Anticardiolipin antibodies in SLE patients tend to precede initial clotting events by several years. Furthermore, the presence of early, prediagnosis aPL seems to herald a more varied, severe clinical course with earlier onset in patients with SLE.

show abstract

“…They are often transient and can disappear after treatment of the infection. [6][7][8][9] Although the aCL antibodies detected in infectious disorders were initially reported to be mainly b 2 GPI independent, b 2 GPI dependent aCL and antibodies against the protein antigens b 2 GPI and prothrombin itself have also been recently reported in many infections. The prevalence of aPL in infections has mainly been reported for the IgG and IgM isotypes, although a few recent studies have also investigated the IgA isotype in some infections.…”

mentioning

confidence: 99%

Anticardiolipin, anti- 2-glycoprotein I and antiprothrombin antibodies in black South African patients with infectious disease

Loizou

Singh²,

Wypkema³

et al. 2003

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

Objectives: To investigate IgG, IgM, and IgA, antiphospholipid antibodies (aPL), against cardiolipin (aCL), b 2 -glycoprotein I (anti-b 2 GPI), and prothrombin (anti-PT), in black South African patients with infectious disease. Unlike patients with systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS), raised levels of aPL in infectious diseases are not usually associated with thrombotic complications. Patients and methods: Serum samples from 272 patients with a variety of infectious diseases (100 HIV positive, 112 leprosy, 25 syphilis, 25 malaria, and 10 HCV patients) were studied and compared with autoantibody levels in 100 normal controls. All three aPL were measured using commercial enzyme linked immunosorbent assay (ELISA) kits. Results: Raised levels of all thee aPL were found in all patient groups studied: aCL in 7%, anti-b 2 GPI in 6%, and aPT in 43% of 100 HIV patients, in 29%, 89%, and 21% of 112 patients with leprosy, in 8%, 8%, and 28% of 25 patients with syphilis, in 12%, 8%, and 28% of 25 patients with malaria, and in 20%, 30%, and 30% of 10 HCV patients studied, respectively. Conclusions: The prevalence of aCL and anti-b 2 GPI in black South African HIV positive patients, or those with syphilis, malaria, or hepatitis C virus is lower than reported for mixed race or white populations. aPT were the most prevalent aPL detected in these patient groups, except in patients with leprosy, for whom anti-b 2 GPI was the most prevalent, and where the spectrum of aPL was similar to that seen in patients with SLE and APS.

show abstract

Which are the Best Biological Markers of the Antiphospholipid Syndrome?

Cited by 71 publications

References 93 publications

Autoimmune Epilepsy: Some Epilepsy Patients Harbor Autoantibodies to Glutamate Receptors and dsDNA on both Sides of the Blood‐brain Barrier, which may Kill Neurons and Decrease in Brain Fluids after Hemispherotomy

Autoimmune Epilepsy: Some Epilepsy Patients Harbor Autoantibodies to Glutamate Receptors and dsDNA on both Sides of the Blood‐brain Barrier, which may Kill Neurons and Decrease in Brain Fluids after Hemispherotomy

The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus

Anticardiolipin, anti- 2-glycoprotein I and antiprothrombin antibodies in black South African patients with infectious disease

Contact Info

Product

Resources

About