Whey hydrolysate compared with cow's milk-based formula for weaning at about 6 months of age in high allergy-risk infants: effects on atopic disease and sensitization

Odelram, H.; Vanto, T.; Jacobsen, Lars; Kjellman, N.‐I. M.

doi:10.1111/j.1398-9995.1996.tb00063.x

Cited by 40 publications

(24 citation statements)

References 9 publications

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“…Although one of those (i.e., the GINI study) was not designed for evaluation of food allergy, it reported on atopic eczema/dermatitis and allergic manifestations including gastrointestinal food allergy (food allergy with manifestations in the gastrointestinal tract), and food sensitization . Two other randomized comparisons failed to find a benefit . However, in one of these, the children were breastfed for a long period and the formula was introduced after the age of 6 months , which may indicate that the window of opportunity for prevention with hydrolyzed formulas is likely to be restricted to the first 6 months.…”

Section: Prevention Strategies During Infancymentioning

confidence: 99%

EAACI Food Allergy and Anaphylaxis Guidelines. Primary prevention of food allergy

Muraro

Halken

Arshad

et al. 2014

Allergy

424

376

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Food allergy can have significant effects on morbidity and quality of life and can be costly in terms of medical visits and treatments. There is therefore considerable interest in generating efficient approaches that may reduce the risk of developing food allergy. This guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Taskforce on Prevention and is part of the EAACI Guidelines for Food Allergy and Anaphylaxis. It aims to provide evidence-based recommendations for primary prevention of food allergy. A wide range of antenatal, perinatal, neonatal, and childhood strategies were identified and their effectiveness assessed and synthesized in a systematic review.Based on this evidence, families can be provided with evidence-based advice about preventing food allergy, particularly for infants at high risk for development of allergic disease. The advice for all mothers includes a normal diet without restrictions during pregnancy and lactation. For all infants, exclusive breastfeeding is recommended for at least first 4-6 months of life. If breastfeeding is insufficient or not possible, infants at high-risk can be recommended a hypoallergenic formula with a documented preventive effect for the first 4 months. There is no need to avoid introducing complementary foods beyond 4 months, and currently, the evidence does not justify recommendations about either withholding or encouraging exposure to potentially allergenic foods after 4 months once weaning has commenced, irrespective of atopic heredity. There is no evidence to support the use of prebiotics or probiotics for food allergy prevention. 590Food allergy can have a significant effect on people's morbidity and quality of life and can be costly in terms of medical visits and treatments. Given the morbidity resulting from food allergy, there is considerable scientific, professional, and lay interest in approaches that may reduce the risk of developing food allergy. This guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Taskforce on Prevention and is part of the EAACI Guidelines for Food Allergy and Anaphylaxis. This guideline aims to provide evidence-based recommendations for the primary prevention of food allergy. The primary audience is allergists throughout Europe, but this guideline is also likely to be of relevance to all other healthcare professionals (e.g., doctors, nurses, and pharmacists) in hospitals' primary care and other ambulatory settings.The causes of food allergy are likely to reflect an interaction between genetic factors and environmental exposure. Genetic factors are currently not modifiable, so strategies to prevent food allergy have tended to focus on early likely exposures to the food proteins most likely to be involved in its pathogenesis. These strategies may be implemented before birth or during breastfeeding, by focusing on the maternal diet, or it may directly target infant nutrition. In addition, there has been a focus on other nutritional f...

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Section: Prevention Strategies During Infancymentioning

confidence: 99%

EAACI Food Allergy and Anaphylaxis Guidelines. Primary prevention of food allergy

Muraro

Halken

Arshad

et al. 2014

Allergy

424

376

View full text Add to dashboard Cite

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“…Hydrolyzed formulas, soy formulas, and early exposure to cow's milk have been tested for prevention of allergy development. Two systematic reviews 60,61 and 5 RCTs [96][97][98][99][100] evaluated the effects of hydrolyzed formulas on the development of food allergies in children. The effects of soy formula were evaluated by 1 systematic review 59 and 1 RCT.…”

Section: Maternal Diet During Pregnancy or Lactation Maternal Diet Dmentioning

confidence: 99%

Diagnosing and Managing Common Food Allergies

Chafen¹,

Newberry²,

Riedl³

et al. 2010

JAMA

424

248

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“…Both these regimens resulted in a very low incidence of CMA and other food allergies until the age of 18 months (100)(101)(102)173). In another recent study (199) no significant effect of supplement with hydrolysate formula (eHF) compared with CMF after the age of 6 months in breastfed HR infants was found. Controlled studies concerning the possible preventive effect of avoidance of other potential food allergens, e.g.…”

mentioning

confidence: 91%

Prevention of allergic disease in childhood: clinical and epidemiological aspects of primary and secondary allergy prevention

Halken

2004

Pediatric Allergy Immunology

193

158

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The development and phenotypic expression of atopic diseases depends on a complex interaction between genetic factors, environmental exposure to allergens,and non-specific adjuvant factors, such as tobacco smoke, air pollution and infections. Preventive measures may include both exposure to allergens and adjuvant risk/protective factors and pharmacological treatment. These measures may address the general population, children at risk for development of atopic disease (high-risk infants), children with early symptoms of allergic disease or children with chronic disease. The objective for this review was to evaluate possible preventive measures as regards prevention of development of allergic disease in childhood--primary prevention--and also some aspects of the effect of specific allergy treatment as regards secondary prevention in children with allergic asthma and allergic rhinoconjunctivitis. In one prospective observational study of a birth cohort of unselected infants we evaluated possible predictive/risk factors. In two prospective intervention studies including 1 yr birth cohorts of high-risk(HR) infants we investigated the effect of feeding HR infants exclusively breast milk (BM) and/or hydrolyzed cow's milk-based formula the first 4-6 months as regards: (i) the allergy preventive effect of BM/extensively hydrolysed formula (eHF) compared with ordinary cow's milk-based formula, (ii) the effect of two different eHFs, a whey (Profylac) and a casein-based (Nutramigen) formula, as regards development of cow's milk protein allergy (CMA), and (iii) a comparison of the preventive effect of eHF (Profylac/Nutramigen) with a partially hydrolyzed cow's milk-based formula (pHF) (NanHA) as regards development of CMA. None of the mothers had a restricted diet during pregnancy or lactation period. In two prospective randomized intervention studies we evaluated the preventive effect of specific allergen avoidance and specific immunotherapy (SIT) in children with allergic asthma and allergic rhinoconjunctivitis, respectively. The combination of atopic heredity and elevated cord blood IgE resulted in the best predictive discrimination as regards development of allergic disease. The optimal high-risk group was defined by either double parental atopic predisposition or single atopic predisposition, the latter combined with a cord blood IgE > or = 0.3 kU/1. 66% of unselected infants were daily exposed to tobacco smoke, which was a significant risk factor for recurrent wheezing until the age of 1.5 yr. HR infants were breastfed for a longer period and less exposed to tobacco smoke than unselected infants. Exclusively BM/eHF for at least 4 months was associated with a significantly reduced cumulative prevalence of CMA [3.6% (5/141) vs. 20%(15/75) in the control group] up to 5 yr. The effect of the two different eHFs was similar. Exclusively breastfed infants were significantly less exposed to tobacco smoke and pets, had solid foods introduced later and belonged to higher social classes. pHF was significantly (p = 0.05) less effec...

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Whey hydrolysate compared with cow's milk-based formula for weaning at about 6 months of age in high allergy-risk infants: effects on atopic disease and sensitization

Cited by 40 publications

References 9 publications

EAACI Food Allergy and Anaphylaxis Guidelines. Primary prevention of food allergy

EAACI Food Allergy and Anaphylaxis Guidelines. Primary prevention of food allergy

Diagnosing and Managing Common Food Allergies

Prevention of allergic disease in childhood: clinical and epidemiological aspects of primary and secondary allergy prevention

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