Prevention of allergic disease in childhood: clinical and epidemiological aspects of primary and secondary allergy prevention

Halken, Susanne

doi:10.1111/j.1399-3038.2004.0148b.x

Cited by 196 publications

(183 citation statements)

References 187 publications

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“…Genetic factors as well as environmental exposure to allergens and not specific factors contribute to the emergence of a complex network that influences atopic diseases 16 .…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Recurrent Wheezing in Infants

Lustosa

Melo

Isidório

et al. 2013

J. Hum. Growth Dev.

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Introduction: wheezing is one of the most common respiratory symptoms in childhood. Regardless of the cause, it is a reason to seek medical care in emergency rooms, especially if there is recurrence of episodes. Very common in childhood, recurrent wheezing has its first episodes in the first year of life. We sought to examine the risk factors for recurrent wheezing in infants in the first year of life. Methods: this is a cross-sectional quantitative study in which a standardized questionnaire of the International Study of Wheezing in Infants, translated and validated in Brazil, consisting of objective questions, applied 40 mothers were enrolled in two Family Health units. Results: the risk factors found were: smoking during pregnancy, family history of asthma, rhinitis and allergic dermatitis, the presence of at least one pet in the home at the time of birth and age at first cold less than or equal to three months of life. No significant relationships were found between males and wheezing, exclusive breastfeeding or numbers of colds in the first year of life. Conclusion: our findings are different from those reported in the literature.

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“…Genetic factors as well as environmental exposure to allergens and not specific factors contribute to the emergence of a complex network that influences atopic diseases 16 .…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Recurrent Wheezing in Infants

Lustosa

Melo

Isidório

et al. 2013

J. Hum. Growth Dev.

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“…94 Breastfed children demonstrate protection for several years afterwards against various pathogens, including Haemophilus influenza type B, respiratory tract infections, otitis media and diarrhea. [95][96][97][98] Select reports indicate that breastfeeding might provide some protection against allergic diseases, such as asthma [99][100][101][102] but to a lesser extent for eczema and allergic rhinitis. 102 However, other cohort studies suggest that breastfeeding does not reduce the incidence of later offspring allergic diseases.…”

Section: Gut Microbiome and Immune Effectsmentioning

confidence: 99%

“…Of these, 237 completed the first-year follow-up and 178 were re-examined at 3 years of age to determine whether breastfeeding was associated with a reduced incidence of otitis media 98 Breastfeeding of varying lengths Breastfed children demonstrated protection for several years against diseases such as HI type B, respiratory tract infections, otitis media, and diarrhea [99][100][101][102] A comprehensive review of 132 studies with 56 being deemed conclusive 99 A comprehensive review of various articles 100 A meta-analyses of 12 prospective articles identified via the 1966-1999 MEDLINE database 101 A meta-analyses of 89 articles from PubMed, CINAHL and EMBASE databases that included a search string of breastfeeding and allergic outcomes 102 Breastfeeding of varying lengths Breastfeeding appeared to against allergic diseases, such as asthma 105,106 A parallel, double-blind placebo-controlled trial of 241 mother-infant (males and females) pairs where 205 infants completed the follow-up studies and were included in the final analyses 105 Study included 1828 school age children (males and females) ranging from 9 to 12 years of age 106 Breastfeeding and maternal probiotic supplementation…”

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confidence: 99%

Homage to the ‘H’ in developmental origins of health and disease

Rosenfeld

2016

J Dev Orig Health Dis

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Abundant evidence exists linking maternal and paternal environments from pericopconception through the postnatal period to later risk to offspring diseases. This concept was first articulated by the late Sir David Barker and as such coined the Barker Hypothesis. The term was then mutated to Fetal Origins of Adult Disease and finally broadened to developmental origins of adult health and disease (DOHaD) in recognition that the perinatal environment can shape both health and disease in resulting offspring. Developmental exposure to various factors, including stress, obesity, caloric-rich diets and environmental chemicals can lead to detrimental offspring health outcomes. However, less attention has been paid to date on measures that parents can take to promote the long-term health of their offspring. In essence, have we neglected to consider the ‘H’ in DOHaD? It is the ‘H’ component that should be of primary concern to expecting mothers and fathers and those seeking to have children. While it may not be possible to eliminate exposure to all pernicious factors, prevention/remediation strategies may tip the scale to health rather than disease. By understanding disruptive DOHaD mechanisms, it may also illuminate behavioral modifications that parents can adapt before fertilization and throughout the neonatal period to promote the lifelong health of their male and female offspring. Three possibilities will be explored in the current review: parental exercise, probiotic supplementation and breastfeeding in the case of mothers. The ‘H’ paradigm should be the focus going forward as a healthy start can indeed last a lifetime.

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“…13 Deben dirigirse a los pacientes de alto riesgo, definidos como individuos que presentan un antecedente alérgico familiar en primer grado.…”

Section: Niveles De Prevención: Definición Y Objetivosunclassified

“…Los objetivos generales son los siguientes: 13 • Disminuir la incidencia de sensibilización y de enfermedades alérgicas.…”

Section: Niveles De Prevención: Definición Y Objetivosunclassified

Prevención de las enfermedades alérgicas en la infancia: entre la teoría y la realidad

2016

Arch Argent Pediat

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RESUMENLas enfermedades alérgicas tienen una prevalencia creciente de modo universal y ocasionan alto impacto sanitario. La investigación está dirigida al estudio de los factores etiológicos y de riesgo de estas enfermedades, que pueden ser potencialmente modificados con estrategias de prevención primaria, secundaria y terciaria. Muchas de esas medidas no tienen un efecto comprobado de manera definitiva, dado que se realizan en un contexto controlado diferente a lo que ocurre en la vida real. Este documento tiene por objetivo revisar las evidencias más actuales sobre prevención de las enfermedades alérgicas considerando las certezas y cuestiones por resolver, y está especialmente centrado en las medidas ambientales, dietéticas, farmacológicas e inmunológicas para los distintos niveles preventivos. Es imperativo un mejor conocimiento de genes y factores ambientales responsables de las enfermedades alérgicas para optimizar las medidas preventivas que permitan revertir la creciente prevalencia de estas enfermedades en la infancia. Palabras clave: alergia, prevención, asma, control ambiental, inmunoterapia. ABSTRACTAllergic diseases have an increasing worldwide prevalence and a great impact on the health related costs. The research is focused on the study of etiological and risk factors of allergic diseases that can potentially be modified with primary, secondary and tertiary prevention strategies. Many of these measures do not have a definitively proven effect taking place in a controlled context different to what happens in real life. This paper aims to review the latest evidence on prevention of allergic diseases considering certainties and unresolved issues and focuses mainly on environmental, dietary, pharmacological and immunological preventive strategies for different levels of prevention. It is imperative to have a better understanding of genetic and environmental factors that cause allergic diseases to optimize preventive measures that are effective in reversing the increasing trend in the prevalence of allergic illnesses in childhood. Key words : allergy, prevention, asthma, environmental control, immunotherapy. http://dx.doi.org/10.5546/aap.2016.277 INTRODUCCIÓNL a s e n f e r m e d a d e s a l é r g i c a s constituyen las patologías crónicas más frecuentes en la edad pediátrica, c o n e l e v a d o s c o s t o s s a n i t a r i o s para el diagnóstico y tratamiento y afectación de la calidad de vida.1 . En Latinoamérica, aproximadamente el Comité Nacional de Alergia Documento de toma de posición Documento desarrollado en el marco del 50° aniversario del

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Prevention of allergic disease in childhood: clinical and epidemiological aspects of primary and secondary allergy prevention

Cited by 196 publications

References 187 publications

Risk Factors for Recurrent Wheezing in Infants

Risk Factors for Recurrent Wheezing in Infants

Homage to the ‘H’ in developmental origins of health and disease

Prevención de las enfermedades alérgicas en la infancia: entre la teoría y la realidad

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