Whey and Casein Proteins and Medium-Chain Saturated Fatty Acids from Milk Do Not Increase Low-Grade Inflammation in Abdominally Obese Adults

Bohl, Mette; Bjørnshave, Ann; Gregersen, Søren; Hermansen, Kjeld

doi:10.1900/rds.2016.13.148

Cited by 13 publications

(6 citation statements)

References 34 publications

(55 reference statements)

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“…However, Pal and Ellis (2010) demonstrated that casein supplementation had no significant influence on plasma inflammatory markers in overweight and obese individuals. This finding is in accordance with the study conducted by Bohl, Bjornshave, Gregersen, and Hermansen (2016) which showed that casein protein did not alter circulating inflammatory markers in abdominally obese adults. Till now, the effect of casein on atherosclerotic progression and its potential mechanism are not fully understood.…”

Section: Introductionsupporting

confidence: 93%

Subcutaneous administration of casein attenuates atherosclerotic progression in male apoE^‐/‐ mice fed with high‐fat diet

Hou

Wang

Zhang

et al. 2020

Food Science & Nutrition

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The impact of casein on atherosclerotic lesion progression remains controversial. In this study, we tested the effect of casein on atherosclerotic development and its potential mechanisms in male apolipoprotein E knockout (apoE ‐/‐ ) mice fed with high‐fat diet (HFD). Male apoE ‐/‐ mice fed with HFD were randomized into HFD group (subcutaneous injection with 0.5 ml of 0.9% sodium chloride daily, n = 6) and HFD + Casein group (subcutaneous injection with 0.5 ml of 10% casein daily, n = 6). Body weight was recorded at baseline and once a week thereafter. After 12 weeks of treatment, plasma lipid and inflammatory markers, and histological characterization of atherosclerotic plaques in the aortic arch and aortic sinus were analyzed. There was no significant difference in weight gain between the two groups after 12 weeks of treatment. Plasma levels of total cholesterol (TC), triglyceride (TG), and low‐density lipoprotein cholesterol (LDL‐C) were significantly lower, while high‐density lipoprotein cholesterol (HDL‐C) level tended to be higher in the HFD + Casein group compared with the HFD group. The positive percentages of atherosclerotic lesions in aortic arch and aortic sinus as well as collagen deposition in aortic sinus plaques were significantly lower in the HFD + Casein group compared with the HFD group. Plasma levels of interleukin (IL)‐1β and granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) were also significantly lower in the HFD + Casein group compared with the HFD group. In conclusion , subcutaneous administration of casein attenuates atherosclerotic lesion progression, possibly through decreasing fibrosis and inflammatory responses in male apoE ‐/‐ mice fed with HFD.

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Section: Introductionsupporting

confidence: 93%

Subcutaneous administration of casein attenuates atherosclerotic progression in male apoE^‐/‐ mice fed with high‐fat diet

Hou

Wang

Zhang

et al. 2020

Food Science & Nutrition

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“…Different nutrients might either enhance or reduce low-grade inflammation [35]. For example, magnesium has been inversely associated with CRP [36], while the two main proteins of dairy, casein and whey, have been suggested to have no effect on inflammatory markers [15,37,38]. The relationship between calcium intake and inflammation has not been fully established, but it has been proposed not to have a role in inflammation [20], and our analyses showed no association with hs-CRP, either.…”

Section: Discussionmentioning

confidence: 59%

“…It is known that diet and dietary components play a role in modulating lowgrade inflammation [13], and for example saturated fatty acids (SFA) are considered as proinflammatory [13,14]. Therefore, dairy fat is suspected to induce inflammation due to its high content of SFA [15]. However, a recent systematic review of randomized controlled trials indicated that consumption of dairy products did not have proinflammatory effects in healthy individuals or in subjects who were overweight, obese or had metabolic abnormalities [16].…”

Section: Introductionmentioning

confidence: 99%

Associations of fermented and non-fermented dairy consumption with serum C-reactive protein concentrations – A cross-sectional analysis

Voutilainen

Hantunen

Ruusunen

et al. 2022

Clinical Nutrition ESPEN

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Background and aims:The results of epidemiological studies on dairy products and low-grade inflammation are scarce and inconsistent. Some studies have suggested that the associations may vary depending on the type of dairy product consumed. The aim of this cross-sectional study was to investigate the associations between intake of fermented and non-fermented dairy products and separately butter and serum high-sensitivity C-reactive protein (hs-CRP), a common inflammation marker, among a population with high dairy intake. Methods: The study included 1338 generally healthy men aged 42e60 years and serum hs-CRP 10 mg/L from the Kuopio Ischaemic Heart Disease Risk Factory Study, examined in 1984e1989. Dietary intakes were assessed using 4-day food records. ANCOVA and linear and logistic regression were used for analyses.Results: The reported mean intakes of fermented and non-fermented dairy products and butter were 189 (SD 217), 522 (SD 330) and 33 (SD 27) g/d, respectively. In the model adjusted for age, year of examination and energy intake (Model 1), higher intake of total dairy, total non-fermented dairy, total milk and butter were associated with higher concentration of serum hs-CRP, whereas fermented dairy intake was not associated with serum hs-CRP. After further adjustment for potential confounders, only higher butter intake remained statistically significantly associated with increased serum hs-CRP (P-trend ¼ 0.049). The odds ratio for elevated hs-CRP (>3 mg/L) in the highest vs. the lowest quartile was 2.50 (95% confidence interval 1.19e5.26, P-trend ¼ 0.02). Conclusions: These results suggest that high intake of butter, but not other dairy products may be associated with increased low-grade inflammation.

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“…As a simple example, if participants donated blood specimens at various times throughout the day, some before and some after meals, there are increased chances of differences in circulating miRNAs being at least partially due to effects of these variables and not more specifically due to biological differences between obesity and MetS. Additionally, these plasma specimens are limited in volume (as they are part of an intervention study), as many other baseline parameters had to be assessed [ 21 , 22 ]. Thus, we elected to perform a pre-screen on a limited number (n=20) of specimens.…”

Section: Discussionmentioning

confidence: 99%

miR-758-3p: a blood-based biomarker that’s influence on the expression of CERP/ABCA1 may contribute to the progression of obesity to metabolic syndrome

et al. 2018

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Due to increasing prevalence of obesity, a simple method or methods for the diagnosis of metabolic syndrome are urgently required to reduce the risk of associated cardiovascular disease, diabetes and cancer. This study aimed to identify a miRNA biomarker that may distinguish metabolic syndrome from obesity and to investigate if such a miRNA may have functional relevance for metabolic syndrome.52 adults with clinical obesity (n=26) or metabolic syndrome (n=26) were recruited. Plasma specimens were procured from all and were randomly designated to discovery and validation cohorts. miRNA discovery profiling was performed, using array technology, on plasma RNA. Validation was performed by quantitative polymerase chain reaction. The functional effect of miR-758-3p on its predicted target, cholesterol efflux regulatory protein/ATP-binding cassette transporter, was investigated using HepG2 liver cells.Custom miRNA profiling of 25 miRNAs in the discovery cohort found miR-758-3p to be detected in the obese cohort but undetected in the metabolic syndrome cohort. miR-758-3p was subsequently validated as a potential biomarker for metabolic syndrome by quantitative polymerase chain reaction. Bioinformatics analysis identified cholesterol efflux regulatory protein/ATP-binding cassette transporter as miR-758-3p’s predicted target. Specifically, mimicking miR-758-3p in HepG2 cells suppressed cholesterol efflux regulatory protein/ATP-binding cassette transporter protein expression; conversely, inhibiting miR-758-3p increased cholesterol efflux regulatory protein/ATP-binding cassette transporter protein expression.miR-758-3p holds potential as a blood-based biomarker for distinguishing progression from obesity to metabolic syndrome and as a driver in controlling cholesterol efflux regulatory protein/ATP-binding cassette transporter expression, indicating it potential role in cholesterol control in metabolic syndrome.

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Whey and Casein Proteins and Medium-Chain Saturated Fatty Acids from Milk Do Not Increase Low-Grade Inflammation in Abdominally Obese Adults

Cited by 13 publications

References 34 publications

Subcutaneous administration of casein attenuates atherosclerotic progression in male apoE^‐/‐ mice fed with high‐fat diet

Subcutaneous administration of casein attenuates atherosclerotic progression in male apoE^‐/‐ mice fed with high‐fat diet

Associations of fermented and non-fermented dairy consumption with serum C-reactive protein concentrations – A cross-sectional analysis

miR-758-3p: a blood-based biomarker that’s influence on the expression of CERP/ABCA1 may contribute to the progression of obesity to metabolic syndrome

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Whey and Casein Proteins and Medium-Chain Saturated Fatty Acids from Milk Do Not Increase Low-Grade Inflammation in Abdominally Obese Adults

Cited by 13 publications

References 34 publications

Subcutaneous administration of casein attenuates atherosclerotic progression in male apoE‐/‐ mice fed with high‐fat diet

Subcutaneous administration of casein attenuates atherosclerotic progression in male apoE‐/‐ mice fed with high‐fat diet

Associations of fermented and non-fermented dairy consumption with serum C-reactive protein concentrations – A cross-sectional analysis

miR-758-3p: a blood-based biomarker that’s influence on the expression of CERP/ABCA1 may contribute to the progression of obesity to metabolic syndrome

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Subcutaneous administration of casein attenuates atherosclerotic progression in male apoE^‐/‐ mice fed with high‐fat diet

Subcutaneous administration of casein attenuates atherosclerotic progression in male apoE^‐/‐ mice fed with high‐fat diet