Where does meniscal damage progress most rapidly? An analysis using three-dimensional shape models on data from the Osteoarthritis Initiative

Dube, B.; Bowes, M.A.; Kingsbury, Sarah R.; Hensor, Elizabeth M A; Muzumdar, Siddhant; Conaghan, Philip G.

doi:10.1016/j.joca.2017.10.012

Cited by 16 publications

(18 citation statements)

References 46 publications

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“…Indeed, parameters of tibial plateau coverage displayed a strong relationship with subsequent KR in this study. This finding is in line with responsiveness to 1-year change reported applying shape models in a progression but non-KR cohort (15).…”

Section: Discussionsupporting

confidence: 88%

Changes in Medial Meniscal Three‐Dimensional Position and Morphology As Predictors of Knee Replacement in Rapidly Progressing Knee Osteoarthritis: Data From the Osteoarthritis Initiative

Roth

Emmanuel

Wirth

et al. 2021

Arthritis Care & Research

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Objective To assess whether quantitative changes in the meniscus predict progression from early knee osteoarthritis (OA) to knee replacement (KR). Methods A nested case–control study was conducted among Osteoarthritis Initiative participants: all 35 case knees with baseline Kellgren/Lawrence (K/L) grade ≤2 that had KR between 36 and 60 months were matched 1:1 by age, sex, and baseline K/L grade to 35 control knees without subsequent KR. Quantitative 3‐dimensional medial meniscus position and morphologic measures were determined from magnetic resonance imaging at the visit just before KR and 2 years before. Paired t‐tests and case–control odds ratios (ORs, standardized per SD of change in controls) were used to compare changes between groups. Results Cases (52% women, age 65 ± 7 years, body mass index [BMI] 30 ± 4 kg/m2, K/L grades 0/1/2: 5/8/22 participants, respectively) and controls (52% women, age 64 ± 7 years, BMI 30 ± 5 kg/m2, K/L grades 0/1/2: 9/4/22 participants, respectively) were similar. Compared to control knees, KR case knees displayed longitudinal changes, specifically, a decrease in tibial plateau coverage, an increase in meniscal extrusion, and a decrease in meniscal width. The odds for KR increased with greater reduction in the percentage of tibial plateau coverage (OR 2.28 [95% CI confidence interval (95% CI) 1.43, 3.64]), a greater increase in maximal extrusion (OR 1.40 [95% CI 1.12, 1.75]), and a greater reduction of mean meniscal width (OR 2.01 [95% CI 1.23, 3.26]). The odds for KR increased with medial compartment cartilage thickness loss (OR 2.86 [95% CI 1.51, 5.41]) for comparison. Conclusion Quantitative measures of meniscal position and morphology are associated with subsequent KR in knees with rapidly progressing knee OA. These findings show that structural changes of the meniscus are related to an important clinical and economic outcome of knee OA.

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Section: Discussionsupporting

confidence: 88%

Changes in Medial Meniscal Three‐Dimensional Position and Morphology As Predictors of Knee Replacement in Rapidly Progressing Knee Osteoarthritis: Data From the Osteoarthritis Initiative

Roth

Emmanuel

Wirth

et al. 2021

Arthritis Care & Research

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“…Medial meniscus thickness and tibial coverage demonstrated moderate but significant changes at 12 months. No significant variation was observed in meniscal volume and extrusion and in lateral meniscus for any of the measures 34 . Another study investigated the effect of weight changes on menisci among subjects with meniscal intrasubstance degeneration over 48 months in OAI dataset 35 .…”

Section: Prediction Prognostic and Progression Studiesmentioning

confidence: 69%

“…Dube et al 34 used shape analysis to determine quantitative morphological changes in menisci among symptomatic knee OA patients. Medial meniscus thickness and tibial coverage demonstrated moderate but significant changes at 12 months.…”

Section: Prediction Prognostic and Progression Studiesmentioning

confidence: 99%

Osteoarthritis year in review 2018: imaging

Nieminen

Casula

Nevalainen

et al. 2019

Osteoarthritis and Cartilage

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Purpose: To provide a narrative review of the most relevant original research published in 2017/2018 on osteoarthritis imaging. Methods: The PubMed database was used to recover all relevant articles pertaining to osteoarthritis and medical imaging published between 1 April 2017 and 31 March 2018. Review articles, case studies and in vitro or animal studies were excluded. The original publications were subjectively sorted based on relevance, novelty and impact. Results and conclusions: The publication search yielded 1,155 references. In the assessed publications, the most common imaging modalities were radiography (N ¼ 708) and magnetic resonance imaging (MRI) (355), followed by computed tomography (CT) (220), ultrasound (85) and nuclear medicine (17). An overview of the most important publications to the osteoarthritis (OA) research community is presented in this narrative review. Imaging studies play an increasingly important role in OA research, and have helped us to understand better the pathophysiology of OA. Radiography and MRI continue to be the most applied imaging modalities, while quantitative MRI methods and texture analysis are becoming more popular. The value of ultrasound in OA research has been demonstrated. Several multi-modality predictive models have been developed. Deep learning has potential for more automatic and standardized analyses in future OA imaging research.

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“…4, the curvature of the upper and lower sides may be recognized in many cases based on the convex shape of the femoral cartilage and the tibial cartilage. However, if this crushed state continued, the impact absorption function of the meniscus might decrease, and potentially cause contact of the femoro-tibial cartilage, suggesting that it may lead to OA progression [22].…”

Section: Discussionmentioning

confidence: 99%

Stage-specific meniscal features predict progression of osteoarthritis of the knee: a retrospective cohort study using data from the osteoarthritis initiative

Kawahara

Sasho

Ohnishi

et al. 2019

BMC Musculoskelet Disord

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BackgroundIn the progression of osteoarthritis (OA) of the knee, a correlation between meniscal posterior segment injuries and medial meniscal extrusion has been reported, but there have been few reports on the relationship with the meniscal shape. The purpose of this study was to clarify the features of the meniscal shape involved in the progression of knee OA.MethodsData were obtained from the Osteoarthritis Initiative (OAI) database. We defined two sets of subjects. One set included 455 knees of subjects whose OA grade on the Kellgren Lawrence (KL) scale progressed in 24 months from baseline and the other set consisted of 455 knees with no progression. The OA progressed subjects were divided to three groups: the “OA change group”, KL0 and KL1 knees that progressed to KL2 and KL3; the “mild change group”, KL2 knees that progressed to KL3; and the “severe change group”, KL2 and KL3 knees that progressed to KL4. The no progression set was divided into three groups whose OA grade remained unchanged. We used magnetic resonance imaging data and manually measured seven items (longitudinal diameter [LD], anterior wedge thickness, anterior wedge width, posterior wedge width, posterior wedge thickness, anterior wedge angle, posterior wedge angle) from the sagittal slice and the extrusion from the coronal slice. These measurements were compared between knees with and without OA progression.ResultsIn the “OA change group” and “mild change group”, the anterior and posterior wedge widths and the extrusion were significantly larger, but the anterior and the posterior wedge angles were significantly smaller. In the “severe change group,” the LD and the extrusion were significantly larger. In each group, there was no uniform tendency for the correlation coefficient of the parameters evaluated.ConclusionsOur findings suggested (1) a larger meniscal LD at the baseline predicted progression of knee OA after 24 months and (2) a larger meniscal width and smaller meniscal angle predicted progression of knee OA after 24 months.

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Where does meniscal damage progress most rapidly? An analysis using three-dimensional shape models on data from the Osteoarthritis Initiative

Abstract: The location of meniscal damage was consistently in the posterior medial region, and two measurements (thickness and tibial coverage) were most responsive. Meniscal measures should add to discriminatory power in OA progression assessment.

Cited by 16 publications

References 46 publications

Changes in Medial Meniscal Three‐Dimensional Position and Morphology As Predictors of Knee Replacement in Rapidly Progressing Knee Osteoarthritis: Data From the Osteoarthritis Initiative

Changes in Medial Meniscal Three‐Dimensional Position and Morphology As Predictors of Knee Replacement in Rapidly Progressing Knee Osteoarthritis: Data From the Osteoarthritis Initiative

Osteoarthritis year in review 2018: imaging

Stage-specific meniscal features predict progression of osteoarthritis of the knee: a retrospective cohort study using data from the osteoarthritis initiative

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