Osteoarthritis year in review 2018: imaging

Nieminen, Miika T.; Casula, Victor; Nevalainen, Mika; Saarakkala, Simo

doi:10.1016/j.joca.2018.12.009

Cited by 35 publications

(17 citation statements)

References 80 publications

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“…4 In addition to direct visualization of articular cartilage, quantitative magnetic resonance imaging (qMRI) provides numerical outcome measures that can be used to nondestructively evaluate early PTOA changes in the tissue. 5,6 MRI relaxation time mapping sequences such as T 1 , T 2 , continuous-wave T 1ρ (CWT 1ρ ), adiabatic T 1ρ (AdT 1ρ ), adiabatic T 2ρ (AdT 2ρ ), and relaxation along a fictitious field (T RAFF ) have been proposed as quantitative biomarkers for the assessment of articular cartilage. 7,8 Native T 1 has been linked to interstitial water content of articular cartilage, 9 while T 2 has been associated with collagen fiber orientation and tissue hydration.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of articular cartilage with quantitative MRI in an equine model of post‐traumatic osteoarthritis

Kajabi

Casula

Sarin

et al. 2020

Journal Orthopaedic Research

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Chondral lesions lead to degenerative changes in the surrounding cartilage tissue, increasing the risk of developing post-traumatic osteoarthritis (PTOA). This study aimed to investigate the feasibility of quantitative magnetic resonance imaging (qMRI) for evaluation of articular cartilage in PTOA. Articular explants containing surgically induced and repaired chondral lesions were obtained from the stifle joints of seven Shetland ponies (14 samples). Three age-matched nonoperated ponies served as controls (six samples). The samples were imaged at 9.4 T. The measured qMRI parameters included T 1 , T 2 , continuous-wave T 1ρ (CWT 1ρ), adiabatic T 1ρ (AdT 1ρ), and T 2ρ (AdT 2ρ) and relaxation along a fictitious field (T RAFF). For reference, cartilage equilibrium and dynamic moduli, proteoglycan content and collagen fiber orientation were determined. Mean values and profiles from full-thickness cartilage regions of interest, at increasing distances from the lesions, were used to compare experimental against control and to correlate qMRI with the references. Significant alterations were detected by qMRI parameters, including prolonged T 1 , CWT 1ρ , and AdT 1ρ in the regions adjacent to the lesions. The changes were confirmed by the reference methods. CWT 1ρ was more strongly associated with the reference measurements and prolonged in the affected regions at lower spin-locking amplitudes. Moderate to strong correlations were found between all qMRI parameters and the reference parameters (ρ = −0.531 to −0.757). T 1 , low spin-lock amplitude CWT 1ρ , and AdT 1ρ were most responsive to changes in visually intact cartilage adjacent to the lesions. In the context of PTOA, these findings highlight the potential of T 1 , CWT 1ρ , and AdT 1ρ in evaluation of compositional and structural changes in cartilage.

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Section: Introductionmentioning

confidence: 99%

Evaluation of articular cartilage with quantitative MRI in an equine model of post‐traumatic osteoarthritis

Kajabi

Casula

Sarin

et al. 2020

Journal Orthopaedic Research

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“…Despite the numerous advantages of available imaging modalities, their limitations are in ultrastructural details at molecular resolution, the complexity of sample preparation procedures, and the lack of the morphological distortion of cells at nanometer resolution [ 32 , 33 , 34 , 35 ]. Osteoarthritis appears as a result of changes in elasticity of cells and tissues; hence, it is crucial to consider aspects such as the mechanical properties and the submicron surface morphology of hyaline cartilage.…”

Section: Introductionmentioning

confidence: 99%

Nanomechanical Properties of Articular Cartilage Due to the PRP Injection in Experimental Osteoarthritis in Rabbits

et al. 2020

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The purpose of this study was twofold. Firstly, we proposed a measurement protocol for the atomic force microscopy (AFM) method to determine the nanomechanical properties of articular cartilage in experimental osteoarthritis in rabbits. Then, we verified if mechanical properties can be evaluated with AFM shortly after platelet-rich plasma (PRP) injection. We hypothesized that the modulus determined by AFM indentation experiments could be utilized as a progressive disease marker during the treatment of osteoarthritis. The rabbits were equally divided into three groups of six: control (group 1); injections of saline (0.5 mL) and 10% surgical talc (Talcum Pharmaceutical®, Minsk, Belarus) were delivered into the right knee under the patella (group 2 and 3); and PRP was injected into the right knee (group 3). In group 2, the arithmetic average of absolute values (Ra) change was a 25% increase; the maximum peak height (Rp) increased by over 102%, while the mean spacing between local peaks (S) increased by 28% (p < 0.05). In group 3, Ra increased by 14% and Rp increased by 32%, while S decreased by 75% (p < 0.05). The Young’s modulus of the surface layers decreased by 18% as a result of induced model of osteoarthritis (IMO) (p < 0.05), and it increased by 9% (p < 0.05) as a result of PRP therapy, which means that the mechanical properties of cartilage were partially recovered. This research demonstrates that Young’s modulus utilized on a nanometer scale has potential to be a progressive disease marker during the treatment of osteoarthritis.

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“…Currently, conventional radiography is considered the gold standard and the most widely used imaging technique. As complementary modalities, magnetic resonance imaging (MRI), ultrasonography (US) and computed tomography (CT) can also be used to diagnose OA on some occasions 4 . However, the clinical diagnosis of osteoarthritis is often problematic since the phenotype of OA is variable, and only a poor correlation between clinical and imaging findings exists 5 .…”

Section: Introductionmentioning

confidence: 99%

Acoustic emissions and kinematic instability of the osteoarthritic knee joint: comparison with radiographic findings

Nevalainen

Veikkola

Thevenot

et al. 2021

Sci Rep

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To evaluate the acoustic emissions (AE) and kinematic instability (KI) of the osteoarthritic (OA) knee joints, and to compare these signals to radiographic findings. Sixty-six female and 43 male participants aged 44–67 were recruited. On radiography, joint-space narrowing, osteophytes and Kellgren–Lawrence (KL) grade were evaluated. Based on radiography, 54 subjects (the study group) were diagnosed with radiographic OA (KL-grade ≥ 2) while the remaining 55 subjects (KL-grade < 2) formed the control group. AE and KI were recorded with a custom-made prototype and compared with radiographic findings using area-under-curve (AUC) and independent T-test. Predictive logistic regression models were constructed using leave-one-out cross validation. In females, the parameters reflecting consistency of the AE patterns during specific tasks, KI, BMI and age had a significant statistical difference between the OA and control groups (p = 0.001–0.036). The selected AE signals, KI, age and BMI were used to construct a predictive model for radiographic OA with AUC of 90.3% (95% CI 83.5–97.2%) which showed a statistical improvement of the reference model based on age and BMI, with AUC of 84.2% (95% CI 74.8–93.6%). In males, the predictive model failed to improve the reference model. AE and KI provide complementary information to detect radiographic knee OA in females.

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Osteoarthritis year in review 2018: imaging

Cited by 35 publications

References 80 publications

Evaluation of articular cartilage with quantitative MRI in an equine model of post‐traumatic osteoarthritis

Evaluation of articular cartilage with quantitative MRI in an equine model of post‐traumatic osteoarthritis

Nanomechanical Properties of Articular Cartilage Due to the PRP Injection in Experimental Osteoarthritis in Rabbits

Acoustic emissions and kinematic instability of the osteoarthritic knee joint: comparison with radiographic findings

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