When the Progression of Disease Lowers Opioid Requirement in Cancer Patients

Mercadante, Sebastiano; Ferrera, Patrizia; Emidio, Loriana Di; Arcuri, Edoardo; Tirelli, Walter

doi:10.1097/ajp.0b013e3181bff90d

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…These symptoms, especially constipation, nausea, and vomiting, are very negatively evaluated and can lead patients to abandon treatment. The therapeutic measures applied to relieve the side effects included switching to another drug, rotating the opioids, changing the administration route, and reducing the dose with a progressive reintroduction, as previously reported [35,38,45–51]. Some of the present patients reported virtually no adverse effects from opioid use, as observed by other authors [34,52].…”

Section: Discussionsupporting

confidence: 78%

Preferences of Caregivers and Patients Regarding Opioid Analgesic Use in Terminal Care

et al. 2014

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These patients and caregivers demonstrated a preference for pain alleviation by opioid treatment and gave negative assessments on adverse digestive effects that can cause this treatment to be abandoned. They expressed interest in receiving more information and in participating in therapeutic decision making, and they reported erroneous beliefs and a lack of information about the effects of these drugs.

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Section: Discussionsupporting

confidence: 78%

Preferences of Caregivers and Patients Regarding Opioid Analgesic Use in Terminal Care

et al. 2014

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“…As seen at the final “tail” of colored ribbons of Figure 10 , there is a reduced response to any of the combinations. In cancer pain, this wind-down component can be masked by the concomitant usage of analgesics like morphine [ 23 ], so that pain relief is erroneously thought to be due to the pharmacological treatment rather than being derived from neural plasticity dynamics.…”

Section: Resultsmentioning

confidence: 99%

The Gate Theory of Pain Revisited: Modeling Different Pain Conditions with a Parsimonious Neurocomputational Model

Peláez

Taniguchi

2016

Neural Plasticity

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The gate control theory of pain proposed by Melzack and Wall in 1965 is revisited through two mechanisms of neuronal regulation: NMDA synaptic plasticity and intrinsic plasticity. The Melzack and Wall circuit was slightly modified by using strictly excitatory nociceptive afferents (in the original arrangement, nociceptive afferents were considered excitatory when they project to central transmission neurons and inhibitory when projecting to substantia gelatinosa). The results of our neurocomputational model are consistent with biological ones in that nociceptive signals are blocked on their way to the brain every time a tactile stimulus is given at the same locus where the pain was produced. In the computational model, the whole set of parameters, independently of their initialization, always converge to the correct values to allow the correct computation of the circuit. To test the model, other painful conditions were analyzed: phantom limb pain, wind-up and wind-down pain, breakthrough pain, and demyelinating syndromes like Guillain-Barré and multiple sclerosis.

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When the Progression of Disease Lowers Opioid Requirement in Cancer Patients

Cited by 2 publications

References 11 publications

Preferences of Caregivers and Patients Regarding Opioid Analgesic Use in Terminal Care

Preferences of Caregivers and Patients Regarding Opioid Analgesic Use in Terminal Care

The Gate Theory of Pain Revisited: Modeling Different Pain Conditions with a Parsimonious Neurocomputational Model

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