When the Effect of Dairy “Protein” on Weight Gain Cannot Be Solely Ascribed to Protein

Mariotti, François; Bos, Cécile; Huneau, Jean‐François

doi:10.1038/oby.2009.495

Cited by 3 publications

(2 citation statements)

References 9 publications

(11 reference statements)

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“…These effects, in turn, act to improve nitric oxide bioavailability to the vascular endothelium by increasing arginine availability and limiting competitive inhibition on NO biosynthesis by asymmetric dimethylarginine [115]. Milk proteins have yet to demonstrate beneficial effects on arterial stiffness, as assessed by pulse wave velocity, in the postprandial state [101,116,117]. Another key measure of peripheral vascular function, flow-mediated dilation, a measure of endothelial-dependent vasodilation, may change acutely as it is depressed in hyperglycemic, hyperlipidemic, and hyperinsulinemic states [118].…”

Section: Vascular Function and Dairymentioning

confidence: 99%

Role of Fluid Milk in Attenuating Postprandial Hyperglycemia and Hypertriglyceridemia

Leary

Tanaka

2020

Nutrients

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Postprandial plasma glucose and triglyceride concentrations are predictive of relative cardiovascular disease (CVD) risk, and the pathogenesis of both insulin resistance and atherosclerosis has been attributed to acute states of hyperglycemia and hypertriglyceridemia. Postprandial lipemia and hyperglycemia suppress vascular reactivity and induce endothelial dysfunction. Epidemiological studies suggest that chronically-high consumption of milk and milk products is associated with a reduced risk of type 2 diabetes, metabolic syndrome, and CVD. The addition of dairy products to meals high in carbohydrates and fat may lessen these risks through reductions in postprandial glucose and triglyceride responses. Purported mechanisms include dairy proteins and bioactive compounds, which may explain the inverse relationship between dairy consumption and cardiometabolic diseases. The current review evaluates the available literature describing the relationships between metabolic dysfunction, postprandial metabolism, and vascular dysfunction and discusses the potential role of milk and dairy products in attenuating these impairments.

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Section: Vascular Function and Dairymentioning

confidence: 99%

Role of Fluid Milk in Attenuating Postprandial Hyperglycemia and Hypertriglyceridemia

Leary

Tanaka

2020

Nutrients

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“…TO THE EDITOR: We appreciate the comments by Mariotti et al (1) in their letter “When the Effect of Dairy ‘Protein’ on Weight Gain Cannot Be Solely Ascribed to Protein” regarding our recent article in which we showed improvements in body composition and insulin sensitivity in obese rats fed complete dairy vs. casein or whey alone (2). Mariotti et al correctly point out that a component of our complete dairy diet, in addition to complete milk protein, was lactose.…”

mentioning

confidence: 96%

Response to “When the Effect of Dairy ‘Protein’ on Weight Gain Cannot Be Solely Ascribed to Protein”

Reimer

Eller

2010

Obesity

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Animal and Plant Protein Sources and Cardiometabolic Health

Mariotti

2019

Advances in Nutrition

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The sources or types of protein in the diet have long been overlooked regarding their link to cardiometabolic health. The picture is complicated by the fact that animal and plant proteins are consumed along with other nutrients and substances which make up the “protein package” so plant and animal protein come with clear nutrient clusters. This review aimed at deciphering the relation between plant and animal protein and cardiometabolic health by examining different nutritional levels (such as amino acids, protein type, protein foods, protein patterns, and associated overall dietary and nutrient patterns) and varying levels of scientific evidence [basic science, randomized controlled trials (RCTs), observational data]. Plant protein in Western countries is a robust marker of nutrient adequacy of the diet, whereas the contribution of animal protein is highly heterogeneous. Yet recent data from large cohorts have confirmed that total and animal proteins are associated with the risk of cardiovascular disease and diabetes, even when fully adjusting for lifestyle and dietary or nutritional factors. Here again, there is marked variability depending on the type of animal protein. Protein from processed red meat and total red meat on the one hand, and from legumes, nuts, and seeds on the other, are often reported at the extremes of the risk range. RCTs using purified proteins have contributed little to the topic to date, inasmuch as the findings cannot readily be extrapolated to current or near-future diets, but RCTs studying whole protein foods have shown a beneficial effect of pulses. Despite the fact that many of the benefits of plant protein reported in observational or interventional studies may stem from the protein package that they convey and the nutrients that they displace, there are also important indications that protein per se may affect cardiometabolic health via the many amino acids that are present in typically contrasting levels in plant compared with animal proteins.

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When the Effect of Dairy “Protein” on Weight Gain Cannot Be Solely Ascribed to Protein

Cited by 3 publications

References 9 publications

Role of Fluid Milk in Attenuating Postprandial Hyperglycemia and Hypertriglyceridemia

Role of Fluid Milk in Attenuating Postprandial Hyperglycemia and Hypertriglyceridemia

Response to “When the Effect of Dairy ‘Protein’ on Weight Gain Cannot Be Solely Ascribed to Protein”

Animal and Plant Protein Sources and Cardiometabolic Health

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