Damage estimates from 80 U.S. earthquakes since 1900 are "normalized" to 2005 dollars by adjusting for inflation, increases in wealth, and changes in population. Factors accounting for mitigation at 1 and 2% loss reduction per year are also considered. The earthquake damage record is incomplete, perhaps by up to 25% of total events that cause damage, but all of the most damaging events are accounted for. For events with damage estimates, cumulative normalized losses since 1900 total $453 billion, or $235 billion and $143 billion when 1 and 2% mitigation is factored, respectively. The 1906 San Francisco earthquake and fire adjusts to $39-$328 billion depending on assumptions and mitigation factors used, likely the most costly natural disaster in U.S. history in normalized 2005 values. Since 1900, 13 events would have caused $1 billion or more in losses had they occurred in 2005; five events adjust to more than $10 billion in damages. Annual average losses range from $1.3 billion to $5.7 billion with an average across data sets and calculation methods of $2.5 billion, below catastrophe model estimates and estimates of average annual losses from hurricanes. Fatalities are adjusted for population increase and mitigation, with five events causing over 100 fatalities when mitigation is not considered, four ͑three͒ events when 1% ͑2%͒ mitigation is considered. Fatalities in the 1906 San Francisco event adjusts from 3,000 to over 24,000, or 8,900 ͑3,300͒ if 1% ͑2%͒ mitigation is considered. Implications for comparisons of normalized results with catastrophe model output and with normalized damage profiles of other hazards are considered.