When is a GIST not a GIST? A case report of synchronous metastatic gastrointestinal stromal tumor and fibromatosis

Lee, Chee Khoon; Hadley, Alison; DeSilva, Keshani; Smith, Greg T.; Goldstein, David

doi:10.1186/1477-7819-7-8

Cited by 10 publications

(8 citation statements)

References 13 publications

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“…In these cases, IAF was first misdiagnosed as GIST recurrence [2,3]. Very recently, a non-random association between GIST and IAF was described.…”

Section: Discussionmentioning

confidence: 99%

“…However, the two cases reported had been treated with imatinib at a dose of 400 mg for liver metastatic GIST. One achieved four years of long-term stable control [3] and the other achieved 11 months of disease control [2], but both developed IAF in primary GIST bed. The second patient was not benefit from imatinib therapy at this dosage.…”

Section: Discussionmentioning

confidence: 99%

“…With the accumulation of knowledges on GIST and long-time follow-up information, GIST patients are found to simultaneously or metachronously have other types of tumors [2-7], some of which are easier to be differentiated from GIST [4,6], while others might be confused with recurrent GIST from the clinical point of view [2,3]. …”

Section: Introductionmentioning

confidence: 99%

“…IAF developed after abdominal surgery and individual with both GIST and IAF were reported recently [2,3] and non-random association between GIST and IAF was established very recently based on data from 10 medical centers [12]. …”

Section: Introductionmentioning

confidence: 99%

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Subsequent intra-abdominal fibromatosis mimicking recurrent gastrointestinal stromal tumor

Jiang

Hou

et al. 2013

Diagn Pathol

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Intra-abdominal fibromatosis (IAF) commonly develops in patients who had abdominal surgery. In rare instances, it occurs subsequent to gastrointestinal stromal tumor (GIST). This special situation has clinical significance in imatinib era. About 1000 patients with GIST in our institution from 1993 to 2010 were re-evaluated based on their clinical and pathological data, the treatment strategies and the follow-up information. We identified 2 patients who developed IAF after GIST resection. Patient 1 was a 54 year-old male and had 5 cm × 4.5 cm × 3.5 cm jejunal GIST excised on February 22, 1994. Three years later, an abdominal mass with 7 cm × 6 cm × 3 cm was identified. He was diagnosed as recurrent GIST from clinical point of view. After excision, the second tumor was confirmed to be IAF. Patient 2 was a 45-year-old male and had 6 cm × 4 cm × 3 cm duodenal GIST excised on August 19, 2008. One year later, a 4 cm mass was found at the original surgical site. The patient refused to take imatinib until the tumor increased to 8 cm six months later. The tumor continued to increase after 6 months’ imatinib therapy, decision of surgical resection was made by multidisciplinary team. The second tumor was confirmed to be IAF with size of 17 cm × 13 cm × 11 cm. Although IAF subsequent to GIST is very rare, it is of clinical significance in imatinib era as an influencing factor for making clinical decision.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1076715989961803

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“…In these cases, IAF was first misdiagnosed as GIST recurrence [2,3]. Very recently, a non-random association between GIST and IAF was described.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Subsequent intra-abdominal fibromatosis mimicking recurrent gastrointestinal stromal tumor

Jiang

Hou

et al. 2013

Diagn Pathol

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“…2 The coexistence of mesenteric fibromatosis with GIST was reported as well. 3 Previous studies showed a significant male predominance with an average age of 59 years. 2 Distinguishing mesenteric fibromatosis from recurrent GIST may be difficult given the similarities in radiologic appearance and c-kit expression in up to 75% of cases of mesenteric fibromatosis that respond to imatinib mesylate.…”

mentioning

confidence: 98%

Gastrointestinal Stromal Tumor, or Another Tumor Type?

2018

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Question: A 53-year-old man was evaluated for nausea, progressive weakness, and loss of energy. He had a history of pituitary adenoma resected approximately 8 months prior, Barrett's esophagus without dysplasia and most relevantly, a history of a 20-cm (Figure A, computed tomography scan of the abdomen) stage IIIb gastric high-grade, predominantly epithelioid, gastrointestinal stromal tumor (GIST; Figure B, note the epithelioid appearing GIST within the black arrows, the oxyntic mucosa within the blue arrows, and the muscularis separating the 2 areas) extirpated by partial gastrectomy and Billroth II approximately 18 months prior. Family history was remarkable for thyroid cancer in a maternal uncle. He denied any history of alcohol use, tobacco use, or illicit drug use. The patient was later noted to have a 3-cm left upper quadrant abdominal mass on surveillance imaging 12 months later while being treated with adjuvant tyrosine kinase inhibitors (imatinib followed by sorafenib). Subsequent laboratory values and physical examination were unremarkable. Repeat imaging demonstrated an enlarging 6.7 Â 7.0-cm mass within the abdominal mesentery anterior to the left kidney (Figure C, repeat computed tomography scan of the abdomen). He was referred for laparoscopic partial small bowel resection and excision of a 10-cm mesenteric mass at the level of the efferent jejunal limb, a 3-cm nodule at the level of the proximal ileum, and 6 smaller nodules within the small bowel mesentery. What is the diagnosis? See the Gastroenterology web site (www.gastrojournal.org) for more information on submitting your favorite image to Clinical Challenges and Images in GI.

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Synchronous gastrointestinal stromal tumors (GIST) and other primary cancers: Case series of a single institution experience

Ferreira

Werutsky

Toneto

et al. 2010

International Journal of Surgery

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When is a GIST not a GIST? A case report of synchronous metastatic gastrointestinal stromal tumor and fibromatosis

Abstract: Background: A number of non-malignant diseases that share similar morphological features as gastrointestinal stromal tumor (GIST) have been reported. Co-existence of GIST with these other diseases is rarely recognized or reported.

Cited by 10 publications

References 13 publications

Subsequent intra-abdominal fibromatosis mimicking recurrent gastrointestinal stromal tumor

Subsequent intra-abdominal fibromatosis mimicking recurrent gastrointestinal stromal tumor

Gastrointestinal Stromal Tumor, or Another Tumor Type?

Synchronous gastrointestinal stromal tumors (GIST) and other primary cancers: Case series of a single institution experience

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