Synchronous gastrointestinal stromal tumors (GIST) and other primary cancers: Case series of a single institution experience

Ferreira, Sheila; Werutsky, Gustavo; Toneto, Marcelo Garcia; Alves, Jarcedy Machado; Piantá, Christina Duarte; Breunig, Raquel Cristine; Rocha, Adriana Brondani da; Grivicich, Ivana; Garicochea, Bernardo

doi:10.1016/j.ijsu.2010.03.008

Cited by 46 publications

(42 citation statements)

References 30 publications

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“…The majority of previous case reports describe small GISTs that were discovered during surgical procedures for another primary malignancy (8). In the present case, two lesions could have been incorrectly diagnosed as a reappearance of colon cancer, as the second colonoscopy and biopsy prior to surgery were indicative of a case of poorly differentiated adenocarcinoma; furthermore, the patient had a history of cancer of the ascending colon.…”

Section: Discussionmentioning

confidence: 99%

Metachronous multiple gastrointestinal stromal tumors and adenocarcinoma of the colon: A case report

Wang

Song

2014

Oncology Letters

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Synchronous or metachronous occurrence of gastrointestinal stromal tumors (GISTs) and other primary gastrointestinal neoplasms has previously been reported. However, to the best of our knowledge, there are few studies regarding metachronous multiple GISTs and adenocarcinoma of the colon. The current case of an 80-year-old male patient who underwent a laparoscopic right hemicolectomy for colonic adenocarcinoma, located in the ascending colon, is presented. Twenty-one months after receiving the laparoscopic right hemicolectomy, two new disc-like bulge lesions in the descending colon and rectosigmoid were identified during an endoscopic follow-up examination, and a segmental bowel resection was performed. The final diagnosis of multiple colonic GISTs was established as a result of histopathological examination and immunohistochemistry.

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Section: Discussionmentioning

confidence: 99%

Metachronous multiple gastrointestinal stromal tumors and adenocarcinoma of the colon: A case report

Wang

Song

2014

Oncology Letters

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“…The synchronous or metachronous occurrence of GIST and other primary neoplasms is not uncommon, with an incidence ranging between 3% and 33% 7–9 14 21. The most common site of an additional malignancy is in the gastrointestinal tract, but studies have also shown occurrences of breast, prostate, uterine, lung and renal cancer 7 8 14 36. Of the studies reporting GIST with additional malignancies, BRCA1/2 mutation status was either not tested or not reported.…”

Section: Discussionmentioning

confidence: 99%

BRCA 1/2 gene mutation and gastrointestinal stromal tumours: a potential association

Waisbren¹,

Uthe

Siziopikou

et al. 2015

BMJ Case Reports

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Mutations of theBRCA1/2genes have been described in association with a number of malignancies including cancers of the breast, ovary, prostate and stomach, but have never been described in relation to gastrointestinal stromal tumours (GIST). We describe a patient with aBRCA28642del3insC mutation who developed prostate cancer, breast cancer and GIST. GIST has been shown to be associated with a number of malignancies, including some of the commonBRCA1/2-related cancers, but it has never been associated withBRCA1/2gene mutations. This report highlights the potential association betweenBRCA1/2mutations and GIST, and aims to raise awareness for further genetic screening in GIST patients.

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“…The most common are carcinomas of gastrointestinal track. Other coexistent tumors include carcinomas of breast, lung, kidney, prostate, female genital track, soft tissue sarcomas, lymphoma, and malignant melanoma [1, 3]. However, the etiology of synchronous occurrence of GISTs with histologically unrelated tumors still remains unclear [1].…”

Section: Discussionmentioning

confidence: 99%

Synchronous Gastric Gastrointestinal Stromal Tumor and Colon Adenocarcinoma: A Case Report

Vasilakaki

Koulia

Tsavari

et al. 2014

Case Reports in Oncological Medicine

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Gastrointestinal stromal tumors (GISTs) represent the majority of primary mesenchymal tumors of the gastrointestinal tract. They are generally considered to be solitary tumors and therefore the synchronous occurrence with other primary malignancies of gastrointestinal track is considered a rare event. Here we present the case of a 75-year-old man admitted to our hospital with a 10-day history of gastrointestinal bleeding. Colonoscopy revealed an ulcerative mass of 4 cm in diameter in the ascending colon. Gastroscopy revealed a bulge in the gastric body measuring 1 cm in diameter with normal overlying mucosa. Surgical intervention was suggested and ileohemicolectomy with regional lymph node resection along with gastric wedge resection was performed. Pathologic examination of the ascending colon mass showed an invasive moderately differentiated adenocarcinoma stage III B (T3N1M0). Grossly resected wedge of stomach showed a well circumscribed intramural tumor which microscopically was consistent with essentially benign gastrointestinal stromal tumor (according to Miettinen criteria). The patient did not receive additional treatment. Two years later the patient showed no evidence of recurrence or metastasis.

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Synchronous gastrointestinal stromal tumors (GIST) and other primary cancers: Case series of a single institution experience

Cited by 46 publications

References 30 publications

Metachronous multiple gastrointestinal stromal tumors and adenocarcinoma of the colon: A case report

Metachronous multiple gastrointestinal stromal tumors and adenocarcinoma of the colon: A case report

BRCA 1/2 gene mutation and gastrointestinal stromal tumours: a potential association

Synchronous Gastric Gastrointestinal Stromal Tumor and Colon Adenocarcinoma: A Case Report

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