When E-cadherin is away, centrosomes can play

Vargas-Hurtado, Diana; Basto, Renata

doi:10.1083/jcb.201712033

Cited by 3 publications

(4 citation statements)

References 10 publications

(36 reference statements)

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“…It consists of the large extracellular and intracellular cytoplasmic structural domains and is highly expressed in epithelial cells. E‐cadherin is also an important component of the adhesion and tight junctions of epithelial cells 28–30 . Vargas‐Hurtado et al found that DDR1 promotes E‐cadherin stability by inhibiting integrin‐β1‐Src activation‐mediated E‐cadherin endocytosis.…”

Section: Resultsmentioning

confidence: 99%

“…With small interfering RNA technology, that study also revealed that reduced DDR1 decreases E‐cadherin expression at adhesions and enhances E‐cadherin endocytosis. Along with increased Src tyrosine 418 phosphorylation at tight junctions, inhibition of Src activity can restore the endocytosis of E‐cadherin and stability of E‐cadherin at tight junctions 28 . In addition, DDR1 expression has been reported to increase the cortical actin structure and promote the adhesion structure stability, while DDR1 downregulation increases stress fibre apparatus, resulting in a decreased adhesion junction stability.…”

Section: Resultsmentioning

confidence: 99%

“…E-cadherin is also an important component of the adhesion and tight junctions of epithelial cells. [28][29][30] Vargas-Hurtado et al found that DDR1 promotes E-cadherin stability by inhibiting integrin-β1-Src activation-mediated E-cadherin endocytosis. With small interfering RNA technology, that study also revealed that reduced DDR1 decreases E-cadherin expression at adhesions and enhances E-cadherin endocytosis.…”

Section: Ddr1 and The Epithelial Barriermentioning

confidence: 99%

“…Along with increased Src tyrosine 418 phosphorylation at tight junctions, inhibition of Src activity can restore the endocytosis of E-cadherin and stability of E-cadherin at tight junctions. 28 In addition, DDR1 expression has been reported to increase the cortical actin structure and promote the adhesion structure stability, while DDR1 downregulation increases stress fibre apparatus, resulting in a decreased adhesion junction stability. DDR1 knockdown increases Cdc42 activation levels, while Cdc42 knockdown rescues DDR1 knockdown-induced E-cadherin endocytosis and cytoskeletal rearrangement, suggesting that DDR1 improves adherens junctions E-cadherin stability through possible Cdc42 inactivation.…”

Section: Ddr1 and The Epithelial Barriermentioning

confidence: 99%

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Discoidin domain receptor 1 may be involved in biological barrier homeostasis

Chen

Zhang

2022

Clinical Pharmacy Therapeu

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What is known and objective: Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase involved in the pathological processes of several diseases, such as keloid formation, renal fibrosis, atherosclerosis, tumours, and inflammatory processes. The biological barrier is the first line of defence against pathogens, and its disruption is closely related to diseases. In this review, we attempt to elucidate the relationship between DDR1 and the biological barrier, explore the potential biological value of DDR1, and review the current research status and clinical potential of DDR1-selective inhibitors. Methods:We conducted an extensive literature search on PubMed to collect studies on the relevance of DDR1 to biological barriers and DDR1-selective inhibitors. With these studies, we explored the relationship between DDR1 and biological barriers and briefly reviewed representative DDR1-selective inhibitors that have been reported in recent years.Results and discussion: First, the review of the potential mechanisms by which DDR1 regulates biological barriers, including the epithelial, vascular, glomerular filtration, blood-labyrinth, and blood-brain barriers. In the body, DDR1 dysfunction and aberrant expression may be involved in the homeostasis of the biological barrier. Secondly, the review of DDR1 inhibitors reported in recent years shows that DDR1-targeted inhibi-

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Ddr1 and The Epithelial Barriermentioning

confidence: 99%

Section: Ddr1 and The Epithelial Barriermentioning

confidence: 99%

See 2 more Smart Citations

Discoidin domain receptor 1 may be involved in biological barrier homeostasis

Chen

Zhang

2022

Clinical Pharmacy Therapeu

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Role of adherens junctions and apical-basal polarity of neural stem/progenitor cells in the pathogenesis of neurodevelopmental disorders: a novel perspective on congenital Zika syndrome

Bustamante

Miró

Velásquez

et al. 2019

Translational Research

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Centrosome Clustering & Chemotherapy

Firdous

Raza

Chotana

et al. 2023

MRMC

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Centrosome abnormalities is the hallmark of cancer. How it affects tumorigenesis is still a mystry. However, the presence of more than two centrosomes at the onset of mitosis often leads to chromosomal instability and subsequent tumorigenesis. Unlike normal cells that undergo repair or apoptosis in response to this instability, cancer cells learn to cope with supernumerary centrosomes through various mechanisms and survive. Centrosome clustering is the most prevalent mechanism, allowing the cancer cells to form two daughter cells through a pseudo-bipolar spindle. Since healthy cells are devoid of the mechanisms involved in clustering, the de-clustering of centrosomes can be considered a promising approach to selectively eliminate cells with extra centrosomes. Several proteins such as PARP, KIFC1, Hsp70, Cortical actin, APC/C-CDH1 complex and Eg5 have been discussed in this review which participate in centrosome clustering, and the inhibition of these proteins can facilitate in impeding tumor growth specifically by declustering centrosomes. In this review, we also present the role of the centrosome in the cell cycle, centrosome amplification, clustering mechanism and reported centrosome de-clustering agents to present the current state of work in the field.

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When E-cadherin is away, centrosomes can play

Abstract: Vargas-Hurtado and Basto highlight recent work from Rhys et al. revealing how E-cadherin affects clustering of extra centrosomes.

Cited by 3 publications

References 10 publications

Discoidin domain receptor 1 may be involved in biological barrier homeostasis

Discoidin domain receptor 1 may be involved in biological barrier homeostasis

Role of adherens junctions and apical-basal polarity of neural stem/progenitor cells in the pathogenesis of neurodevelopmental disorders: a novel perspective on congenital Zika syndrome

Centrosome Clustering & Chemotherapy

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