Discoidin domain receptor 1 may be involved in biological barrier homeostasis

Abstract

What is known and objective: Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase involved in the pathological processes of several diseases, such as keloid formation, renal fibrosis, atherosclerosis, tumours, and inflammatory processes. The biological barrier is the first line of defence against pathogens, and its disruption is closely related to diseases. In this review, we attempt to elucidate the relationship between DDR1 and the biological barrier, explore the potential biological value of DDR1, and review the current research status and clinical potential of DDR1-selective inhibitors. Methods:We conducted an extensive literature search on PubMed to collect studies on the relevance of DDR1 to biological barriers and DDR1-selective inhibitors. With these studies, we explored the relationship between DDR1 and biological barriers and briefly reviewed representative DDR1-selective inhibitors that have been reported in recent years.Results and discussion: First, the review of the potential mechanisms by which DDR1 regulates biological barriers, including the epithelial, vascular, glomerular filtration, blood-labyrinth, and blood-brain barriers. In the body, DDR1 dysfunction and aberrant expression may be involved in the homeostasis of the biological barrier. Secondly, the review of DDR1 inhibitors reported in recent years shows that DDR1-targeted inhibi-

Disease-associated astrocytes and microglia markers are upregulated in mice fed high fat diet

“…In addition to astrocytes, it also expresses among myelinating oligodendrocytes, myelin and neurons 80 . Ddr1 is important for the regulation of microglial activity 81 . It has been reported that Ddr1 mediates inflammatory response of microglia induced by collagen 82 , which may contribute to the neuroinflammation and neurodegeneration.…”