Wheeze trajectories are modifiable through early‐life intervention and predict asthma in adolescence

Owora, Arthur H.; Becker, Allan B.; Chan‐Yeung, Moira; Chan, Edmond S.; Chooniedass, Rishma; Ramsey, Clare D.; Watson, Wade; Azad, Meghan B.

doi:10.1111/pai.12922

Cited by 32 publications

(73 citation statements)

References 32 publications

(89 reference statements)

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“…Our findings reinforce the evidence for distinguishing early transient wheezing, that recovers spontaneously, from atopic persistent wheezing, as previously shown by Martinez et al and confirmed by more recent studies that also reported several persistent profiles . We observed one profile of persistent wheezers that might gather all non‐transient wheezers, as separation between these profiles is not so clear‐cut, and overlay between related clinical features—including atopic status and lung function—has been reported .…”

Section: Discussionsupporting

confidence: 91%

Unsupervised trajectories of respiratory/allergic symptoms throughout childhood in the PARIS cohort

Bougas

Just

Beydon

et al. 2019

Pediatric Allergy Immunology

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Background Natural course and co‐occurrence of asthma, eczema, and allergic rhinitis through childhood are still not fully documented. We aim to identify and characterize profiles based on the time course, severity, and apparent triggers of respiratory/allergy symptoms in school‐aged children. Methods Data on occurrence, severity, and triggers of asthma, rhinitis, and dermatitis symptoms were collected annually during the follow‐up of the PARIS birth cohort. Children with similar symptom trajectories until 8‐9 years were grouped into profiles using multidimensional (all symptoms considered simultaneously) cluster analysis. Associations between profiles and different health outcomes were analyzed using logistic or linear regression models. Results Six distinct symptomatic profiles were identified. A profile was defined by persistent dermatitis symptoms, associated with sensitization to food and aeroallergens. Two profiles were characterized by wheezing: one with early transient wheezing and the other with persistent wheezing related to doctor‐diagnosed asthma, airway obstruction, and perennial aeroallergen sensitization. Three profiles were characterized by rhinitis symptoms: one non‐allergic and two allergic, either with persistent rhinitis symptoms related to allergic multimorbidity and sensitization to perennial aeroallergens, or with late‐onset symptoms, related to both pollen and perennial aeroallergens sensitization as well as low lung function. Conclusion This study brings further insights into the developmental profiles of respiratory/allergic outcomes from birth to school age. The identified profiles clearly differed regarding objective features such as diagnosed morbidity, sensitization, or lung function measurements, thus highlighting their biologic and clinical relevance. Allergic rhinitis profiles deserve particular attention, since they were likely to be involved in multimorbidity patterns.

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Section: Discussionsupporting

confidence: 91%

Unsupervised trajectories of respiratory/allergic symptoms throughout childhood in the PARIS cohort

Bougas

Just

Beydon

et al. 2019

Pediatric Allergy Immunology

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“…Clearly, it is important to identify early risk factors for asthma, as well as wheeze trajectories, in order to apprehend the disease as shown recently in PAI. [10][11][12] Other recent studies have also shown that global, or allergen-specific sensitization (hen's egg) may change the prevalence of respiratory allergy at a later age. 13,14 Accidental allergic reactions in the community are a major concern to parents and health professionals.…”

Section: Fecal Metabolites and Early Sensitization Influence Asthma mentioning

confidence: 99%

“…Sensitization to multiple allergens at single time‐points, increasing sIgE levels and SPT wheal sizes, and persistent sensitization during childhood were associated with increased risk of asthma at age 13, suggesting the use of quantitative and repetitive sensitization measurements when assessing the risk of developing asthma. Clearly, it is important to identify early risk factors for asthma, as well as wheeze trajectories, in order to apprehend the disease as shown recently in PAI . Other recent studies have also shown that global, or allergen‐specific sensitization (hen's egg) may change the prevalence of respiratory allergy at a later age …”

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confidence: 99%

Fecal metabolites and early sensitization influence asthma, and how to prevent anaphylaxis in the community

Eigenmann

2019

Pediatric Allergy Immunology

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“…They also point out that this increase in lung function was not associated with any clinically relevant protective effect on allergy and asthma development. Asthma development in relation to the environment is a key issue in allergy and asthma prevention, which might largely influence the long‐term prognosis of asthma‐affected children 4,5 . PAI has recently reported other studies in relation to the topic.…”

mentioning

confidence: 99%

Management of food allergy and species‐related exposure on asthma

Eigenmann

2020

Pediatric Allergy Immunology

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This issue of Pediatric Allergy and Immunology has a strong focus on food allergy, and the review article by Krogulska and Wood which opens the issue also addresses this topic. 1 These authors provide a thorough overview on the diagnosis of peanut allergies, focusing on in vitro methods including component-resolved diagnosis, but also on food challenges, as well as on other diagnostic tests. In addition, they discuss how the interpretation of IgE testing of various major allergens may change according to the geographic location. This aspect is often under-estimated and may significantly influence the diagnosis. At the end of the review, a very useful diagnostic algorithm may be of great help to the reader.Besides, a recent report published in PAI on how binding of specific IgE to major peanut allergens varies after oral immunotherapy (OIT) may complement the information given in the above-cited review. 2

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Wheeze trajectories are modifiable through early‐life intervention and predict asthma in adolescence

Cited by 32 publications

References 32 publications

Unsupervised trajectories of respiratory/allergic symptoms throughout childhood in the PARIS cohort

Unsupervised trajectories of respiratory/allergic symptoms throughout childhood in the PARIS cohort

Fecal metabolites and early sensitization influence asthma, and how to prevent anaphylaxis in the community

Management of food allergy and species‐related exposure on asthma

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