What We Should Know Before Using Tissue Engineering Techniques to Repair Injured Tendons: A Developmental Biology Perspective

Liu, Chia-Feng; Aschbacher-Smith, Lindsey; Barthelery, Nicolas J.; Dyment, Nathaniel A.; Butler, David L.; Wylie, Christopher

doi:10.1089/ten.teb.2010.0662

Cited by 141 publications

(130 citation statements)

References 112 publications

(132 reference statements)

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“…Intrinsic healing is predominantly controlled by resident TCs, whilst the extrinsic is controlled by cells migrating from the external surrounding tissues [108]. Due to the low activity / reparative capacity of the resident cells [1, [109][110][111][112], the extrinsic healing mechanism is activated. In reality, it is likely that a combination of both mechanisms occurs, with different injuries and injury sites determining which mechanism is the overriding one [113].…”

Section: Tendon Healingmentioning

confidence: 99%

“…The limited regenerative capacity of tendons has been attributed to the low activity and low reparative potential of the resident cells [1, 109,110,112]. Further, permanently differentiated and stem cell populations act as a biological factory [1] of a spectrum of bioactive and biotrophic molecules that regulate several physiological processes [211][212][213].…”

Section: Delivery Of Viable Cell Populationsmentioning

confidence: 99%

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The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

172

188

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Section: Tendon Healingmentioning

confidence: 99%

Section: Delivery Of Viable Cell Populationsmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

172

188

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“…Given that tissue graft based therapies have failed to restore native tendon function, it is anticipated that the tissue-engineering arpeggio (scaffolds, cells, biologics alone or in combination) would provide a functional therapy in the years to come [1][2][3][4][5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Substrate topography: A valuable in vitro tool, but a clinical red herring for in vivo tenogenesis

et al. 2015

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractControlling the cell-substrate interactions at the bio-interface is becoming an inherent element in the design of implantable devices. Modulation of cellular adhesion in vitro, through topographical cues, is a well-documented process that offers control over subsequent cellular functions. However, it is still unclear whether surface topography can be translated into a clinically functional response in vivo at the tissue / device interface. Herein, we demonstrated that anisotropic substrates with a groove depth of ~317 nm and ~1,988 nm promoted human tenocyte alignment parallel to the underlying topography in vitro. However, the rigid poly(lactic-co-glycolic acid) substrates used in this study upregulated the expression of chondrogenic and osteogenic genes, indicating possible tenocyte trans-differentiation. Of significant importance is that none of the topographies assessed (~37 nm, ~317 nm and ~1,988 nm groove depth) induced extracellular matrix orientation parallel to the substrate orientation in a rat patellar tendon model. These data indicate that two-dimensional imprinting technologies are useful tools for in vitro cell phenotype maintenance, rather than for organised neotissue formation in vivo, should multifactorial approaches that consider both surface topography and substrate rigidity be established.

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“…The natural healing potential of tendon tissue is low due to hypocellularity, hypovascularity and a low metabolic rate compared to other soft tissues (Bray et al, 1996;Liu et al, 2011;Sharma and Maffulli, 2005a). Therefore, the healing process is slow (James et al, 2008) and takes months or even years.…”

Section: Introductionmentioning

confidence: 99%

Tendon healing induced by chemically modified mRNAs

Groth¹,

Berezhanskyy²,

Aneja³

et al. 2017

eCM

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Tendon disorders are frequent both in human and veterinary medicine with high re-injury rates and unsatisfactory therapeutic treatments. Application of naked, chemicallymodified mRNA (cmRNA), encoding for therapeutic proteins, is an innovative approach to address tendon healing. In the current study, we demonstrated that injection of naked cmRNA, diluted in a glucose-containing solution, into tendons resulted in high protein expression in healthy and experimentally-injured tendons. Injection of bone morphogenetic protein 7 (BMP-7)-encoding cmRNA resulted in a significantly higher expression of BMP-7 protein and reduced formation of collagen type III, compared to vehicle control. Moreover, in a large animal model, reporter protein expression was detectable not only in healthy, but also in experimentally-injured, severely inflamed tendons. Summarising, these results demonstrated the potential of cmRNAs encoding for therapeutic proteins as a new class of drugs for the treatment of tendon disorders.

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What We Should Know Before Using Tissue Engineering Techniques to Repair Injured Tendons: A Developmental Biology Perspective

Cited by 141 publications

References 112 publications

The past, present and future in scaffold-based tendon treatments

The past, present and future in scaffold-based tendon treatments

Substrate topography: A valuable in vitro tool, but a clinical red herring for in vivo tenogenesis

Tendon healing induced by chemically modified mRNAs

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