What we actually know about the pathogenicity of Bacteroides pyogenes

Abstract

The aim of the study was to evaluate the pathogenic potential of Bacteroides pyogenes, rarely identified in clinical laboratories anaerobic bacteria. To increase the knowledge about this poorly understood anaerobic microorganism, the study also includes cases of infections described so far in the literature. Only the use of 16S rRNA sequencing and mass spectrometry technique allowed the identification of B. pyogenes from clinical specimens. We reported 13 severe human infections caused by B. pyogenes. Bacteria were cultured from the wound after biting by animals, chronic infections within the oral cavity, from patients with histologically or radiological proven osteomyelitis, surgical site infection, and from urine sample collected after a urological procedure. Most (9/13) of the patients required hospitalization. Almost 70% of them needed urgent admission via the emergency room. Two inpatients due to a life-threatening condition were admitted to the intensive care unit. Almost 50% of isolates were resistant to penicillin. All resistant to penicillin strains were isolated from skin and mucous membrane infections.

Vaginal microbiota signatures in healthy and purulent vulvar discharge sows

“…Interestingly, the phylum Bacteroidetes and the genus Bacteroides were found in high relative abundances only in the metagenomic approach, in contrast to the culture-dependent method. This may be due to the difficulty of traditional culture methods to cover fastidious bacteria, such as the obligate anaerobes Bacteroides members 32 . This reinforces that the metagenomic approach may be more effective in characterizing the microbiota due to its higher resolution to identify low-abundance or fastidious microbes, while culture-dependent methods can confirm the viability of the identified agents, making them complementary techniques.…”

“…The pathogenesis of B. pyogenes infections is still unclear, especially in the swine species. But recent studies described this agent in important infections in humans, such as purulent abscesses, infected wounds, and urinary tract infections 32 . Only herd-3 showed a significant difference in the ANCOM method for the higher relative abundance of B. pyogenes in VD females, which could explain the difference in beta-diversity observed between the HE and VD groups for this herd.…”

C-phycocyanin alleviated cisplatin-induced oxidative stress and inflammation via gut microbiota—metabolites axis in mice

“…Bacteroides is different from Lactobacillus genius. Though there are pathogenic bacteria species in Bacteroides , such as Bacteroides pyogenes ( 44 ), yet probiotics like Bacteroides acidifaciens , which can guard against liver damages, are included. The other prebiotic effects of Bacteroides acidifaciens were summarized in our previous review ( 14 ).…”

“…Bacteroides acidifaciens has good consistency with liver injury. Combined with the literature ( 44 ), the real significance of Bacteroides acidifaciens bacteria may be used as a predictive biomarker of liver injury.…”

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“…Curiosamente, o filo Bacteroidetes e o gênero Bacteroides foram encontrados em alta abundância relativa apenas na abordagem metagenômica, em contraste com o método dependente de cultura. Isso pode ser devido à dificuldade dos métodos tradicionais de cultura em isolar bactérias fastidiosas, como membros do gênero de anaeróbios obrigatórios Bacteroides (MAJEWSKA; KIERZKOWSKA;KAWECKI, 2021). Isso reforça que a abordagem metagenômica pode ser mais eficaz na caracterização da microbiota devido à sua maior resolução para identificar agentes em baixa abundância ou fastidiosos, enquanto a abordagem dependente da cultura pode confirmar a viabilidade dos agentes detectados, tornando-as técnicas complementares.…”