What’s next in the use of opacifiers for cosmetic coatings of solid dosage forms? Insights on current titanium dioxide alternatives

Palugan, Luca; Spoldi, Mattia; Rizzuto, Franco; Guerra, Norberto; Uboldi, Marco; Cerea, Matteo; Moutaharrik, Saliha; Melocchi, Alice; Gazzaniga, A.; Zema, L.

doi:10.1016/j.ijpharm.2022.121550

Cited by 8 publications

(1 citation statement)

References 22 publications

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“…However, the “L *” values were not statistically significant from each other. On the other hand, “a *” and “b *” values are chromic parameters, wherein “a *” and “b *” parameters represent green-red and blue-yellow opponent colors, respectively [ 43 , 44 ]. The negative values of “a *” and “b *” represent green and blue colors.…”

Section: Resultsmentioning

confidence: 99%

Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin

Shaikh

Anis

Poulose

et al. 2022

Gels

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Bigels are biphasic semisolid systems that have been explored as delivery vehicles in the food and pharmaceutical industries. These formulations are highly stable and have a longer shelf-life than emulsions. Similarly, cellulose-based hydrogels are considered to be ideal for these formulations due to their biocompatibility and flexibility to mold into various shapes. Accordingly, in the present study, the properties of an optimized guar gum hydrogel and sesame oil/candelilla wax oleogel-based bigel were tailored using date palm-derived cellulose nanocrystals (dp-CNC). These bigels were then explored as carriers for the bioactive molecule moxifloxacin hydrochloride (MH). The preparation of the bigels was achieved by mixing guar gum hydrogel and sesame oil/candelilla wax oleogel. Polarizing microscopy suggested the formation of the hydrogel-in-oleogel type of bigels. An alteration in the dp-CNC content affected the size distribution of the hydrogel phase within the oleogel phase. The colorimetry studies revealed the yellowish-white color of the samples. There were no significant changes in the FTIR functional group positions even after the addition of dp-CNC. In general, the incorporation of dp-CNC resulted in a decrease in the impedance values, except BG3 that had 15 mg dp-CNC in 20 g bigel. The BG3 formulation showed the highest firmness and fluidity. The release of MH from the bigels was quasi-Fickian diffusion mediated. BG3 showed the highest release of the drug. In summary, dp-CNC can be used as a novel reinforcing agent for bigels.

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Section: Resultsmentioning

confidence: 99%