What’s new in HIV dermatology?

Coates, Sarah J.; Leslie, Kieron

doi:10.12688/f1000research.16182.1

Cited by 19 publications

(25 citation statements)

References 51 publications

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“…In immunodeficient HIV patients, even saprophytes may penetrate into deeper layers of the tissue, frequently causing pruritic folliculitis. Other typical skin conditions in PLWH include dry skin, chronic pruritus, exacerbation of atopic dermatitis, and nodular prurigo [21,22]. Apart from common dermatoses (oral candidiasis, herpes zoster, seborrheic eczema), immunodeficient patients may also show skin conditions that are otherwise rare.…”

Section: Hiv-associated Dermatosesmentioning

confidence: 99%

HIV medicine for dermatologists and venereologists

Eßer

Sammet

2020

J Deutsche Derma Gesell

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Broad administration of combined antiretroviral therapy (ART) has dramatically reduced the morbidity and mortality of the HIV-infection and substantially improved the life expectancy of people living with HIV (PLWH). PLWH, who are effectively treated with an ART, are considered to be unable to transmit HIV. The standard of care is usually an antiretroviral single tablet regimen. Since 2015 the Robert Koch Institute has reported a slight decrease in the rate of recently diagnosed HIV-infections in Germany, but the proportion of late presenters (initial diagnosis in advanced stages of infection) has remained consistently high at around 32 % since 2005. HIV-infections have not been diagnosed in 10,800 PLWH so far. In comparison to the general population PLWH suffer more frequently from skin diseases. Depending on the stage of immunodeficiency, untreated PLWH develop HIV indicator diseases of the skin and the mucocutaneous membranes. Knowledge of these diseases facilitates the selection of individuals who should be offered HIV testing. Early diagnosis of HIV-infections allows early introduction of the ART, prevents the spread of HIV and reduces the mortality rates and treatment costs associated with late diagnosis. HIV is a predominantly sexually transmitted infection. Through focused sexual anamnesis and the diagnosis of HIV indicator diseases and other sexually transmitted infections, dermatovenereologists in particular may be able to identify previously undiagnosed PLWH and persons with an increased risk of HIV infection, enabling initiation of ART in the former and pre-exposure prophylaxis counseling in the latter.

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Section: Hiv-associated Dermatosesmentioning

confidence: 99%

HIV medicine for dermatologists and venereologists

Eßer

Sammet

2020

J Deutsche Derma Gesell

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“…Tudo isto propicia ao requerimento de opções farmacológicas mais agressivas. 14 Quando associado à baixa contagem de CD4, o HPV expressa maior risco de malignização das lesões. 15 Apesar da melhoria da imunidade, mediante a Terapia Antirretroviral (TARV) ter promovido uma redução no tamanho e número de lesões verrucosas plantares e da incidência das genitais, a maior sobrevida dos pacientes também possibilitou o processo oncogênico do HPV e assim uma maior incidência de lesões malignas, tais como lesões intraepiteliais escamosas de alto grau na região anal, peniana e carcinoma de células escamosas periungueais, 15 principalmente, entre Homens que fazem Sexo com Homens (HSH).…”

Section: Resultsunclassified

Manifestações dermatológicas no HIV: uma revisão de literatura

Gomes

Lima

Ribeiro

et al. 2021

RECIS

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Trata-se de uma revisão de literatura narrativa sobre as principais dermatopatias que acometem pacientes com soropositividade para o vírus causador da Síndrome da Imunodeficiência Adquirida (AIDS). Foram abordadas as principais afecções cutâneas, bem como as formas atípicas de manifestação delas em conjunto com o vírus da imunodeficiência humana. No total foram selecionados 14 artigos sobre o tema em diferentes bases de dados, com data de publicação no período compreendido entre 2011 e 2020. As principais manifestações relatadas pelos artigos foram infecção pelo Papilomavírus Humano, herpes-zoster, herpes simples, dermatite seborreica, psoríase, necrólise epidérmica tóxica, síndrome de Stevens Johnson e neoplasias. Conclui-se, dessa revisão, a relevância em identificar tais manifestações de forma precoce em pessoas que vivem com o vírus da imunodeficiência humana. Além disso, verificou-se ser necessário um melhor treinamento de profissionais de saúde no reconhecimento de doenças de pele definidoras da síndrome da imunodeficiência adquirida.

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“…Along with the occurrence of acquired immunodeficiency syndrome (AIDS) other dermatological conditions such as extensive oral candidiasis, herpes zoster and oral hairy leukoplakia have been described as indicators for this syndrome (4). The introduction of highly active antiretroviral therapy (HAART) more than 20 years ago has diminished and altered the range of dermatological conditions, with improved immunosuppression of CD4 lymphocytes (5,6). However, PLWH still face a number of viral skin infections, chronic inflammation or various forms of skin cancer (5).…”

Section: Introductionmentioning

confidence: 99%

“…The introduction of highly active antiretroviral therapy (HAART) more than 20 years ago has diminished and altered the range of dermatological conditions, with improved immunosuppression of CD4 lymphocytes (5,6). However, PLWH still face a number of viral skin infections, chronic inflammation or various forms of skin cancer (5). Understanding the complex relationship between the immune system and dermatoses suffered by PLWH can lead to a better therapeutic approach and appropriate management.…”

Section: Introductionmentioning

confidence: 99%

Perspectives on skin disorder diagnosis among people living with HIV in southeastern Romania

et al. 2020

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The beginnings of the human immunodeficiency virus (HIV) pandemic are closely linked to dermatological conditions. A large part of the population living with HIV (PLWH) has a series of skin conditions that determine at some point, a visit to the dermatologist. The introduction of highly active antiretroviral therapy (HAART) more than 20 years ago has diminished the range of dermatological conditions, with improved immunosuppression of CD4 lymphocytes. The study aimed to describe the prevalence of the diagnosed type of skin changes in PLWH receiving antiretroviral therapy and their stratification according to the degree of immunodeficiency. A prospective study was conducted on 57 PLWH evaluated monthly at an HIV outpatient clinic, from a tertiary hospital in southeastern Romania. Clinical examination and dermoscopy revealed the existence of a wide range of dermatological conditions; all 57 patients (100%) being diagnosed with one or more dermatological conditions. As our study shows, the prevalence of different dermatoses among PLWH varies depending on the geographical region. At the same time, under HAART, the image of dermatoses associated with decreased immunity from HIV infection has changed. The skin changes of PLWH no longer fully follow the classical staging, based on the degree of immunosuppression.

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What’s new in HIV dermatology?

Cited by 19 publications

References 51 publications

HIV medicine for dermatologists and venereologists

HIV medicine for dermatologists and venereologists

Manifestações dermatológicas no HIV: uma revisão de literatura

Perspectives on skin disorder diagnosis among people living with HIV in southeastern Romania

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