What lies behind and beyond acute COVID‐19 pain?

Kubota, Gabriel Taricani; Moisset, Xavier

doi:10.1002/ejp.1889

Cited by 2 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pain was reported to occur in 30%–70% of patients during acute COVID‐19 (Jena et al, 2022; Karaarslan et al, 2022; Knox et al, 2021; Kubota & Moisset, 2022; Kurçaloğlu et al, 2021; Murat et al, 2020; Oguz‐Akarsu et al, 2022; Ojeda et al, 2022; Şahin et al, 2021). However, few studies are available on its natural history beyond the first months of the infection.…”

Section: Discussionmentioning

confidence: 99%

Pain paths among post‐COVID‐19 condition subjects: A prospective cross‐sectional study with in‐person evaluation

Kubota

Soares

Fonseca

et al. 2023

European Journal of Pain

View full text Add to dashboard Cite

Background: New-onset chronic pain has been acknowledged as part of the post-COVID-19 condition. However, available fine-grained data about its clinical phenotype, trajectories and main associated characteristics remain scarce. We described the distinct temporal evolutions of post-COVID-19 pain and their epidemiological and phenotypical features. Methods: A prospective cross-sectional study enrolled post-COVID-19 condition patients (i.e. who had persisting COVID-19-related symptoms over 30 days since their first positive laboratory test), whose COVID-19 diagnosis had been supported by RT-PCR of oral/nasopharyngeal swab or serology. They underwent in-person evaluations with a structured interview, pain and quality-of-life-related questionnaires and thorough physical examination. Chronic pain (CP) and probable neuropathic pain (NP) were defined according to IASP criteria. Results:The present study included 226 individuals, 177 (78.3%) of whom presented over 3 months since their first COVID-19 symptom. New-onset pain occurred in 170 (75.2%) participants and was chronic in 116 (68.2%). A chronic course was associated with COVID-19-related hospitalization, new-onset fatigue, lower cognitive performance, motor and thermal sensory deficits, mood and sleep impairments and overall lower quality-of-life levels. Probable NP occurred in only 7.6% new-onset pain patients, and was associated with pain chronification, new-onset fatigue, motor and thermal sensory deficits, mechanical allodynia and lower rates of SARS-CoV-2 vaccination. Previous CP was reported by 86 (38.1%) individuals and had aggravated after the infection in 66 (76.7%) of them, which was associated with orthostatic hypotension. Conclusions: Post-COVID pain phenomena follow different paths, which are associated with specific clinical and epidemiological features, and possibly distinct underlying mechanisms, prognostic and therapeutic implications. Significance: COVID-19-related pain usually follows a chronic course and is non-neuropathic. Its possible courses and phenotypes are associated with distinct

show abstract