What Is the Relationship Between Paget's Disease of Bone and Hyperparathyroidism?

Brandi, Maria Luisa; Falchetti, Alberto

doi:10.1359/jbmr.06s213

Cited by 14 publications

(11 citation statements)

References 46 publications

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“…Common histologic features of both diseases are increased bone marrow fibrosis and vascularity. 39 The multiple endocrine neoplasia type 1 (MEN1) gene involved in the pathogenesis of hyperparathyroidism interacts with NF-kB proteins (40). Some patients with Paget disease (12%-18%) have increased serum PTH levels.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of Primary Hyperparathyroidism and Paget Disease

Polymeris¹,

Doumouchtsis²,

Karga³

2009

The Endocrinologist

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A 76-year-old woman presented with a 2-month history of high serum calcium, low phosphate, and high levels of alkaline phosphatase. Serum parathyroid hormone, in repeated measurements, was inappropriately high for the high serum calcium levels and the patient had hypercalciuria. The diagnosis of primary hyperparathyroidism was made. The patient also had very high levels of serum alkaline phosphatase and high bone turnover. Her bone mineral density evaluation by dual energy x-ray absorptiometry showed osteoporosis in the lumbar spine and osteopenia in femoral neck. Skull radiographs and a further bone scintigraphic study with Tc-99m methylene diphosphonate revealed Paget disease. Successful parathyroidectomy was performed and a parathyroid adenoma was removed. On reevaluation, no evidence of residual hyperparathyroidism was found. Bone metabolism was improved but remained disordered. The patient was then treated with IV zolendronic acid.

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Section: Discussionmentioning

confidence: 99%

Coexistence of Primary Hyperparathyroidism and Paget Disease

Polymeris¹,

Doumouchtsis²,

Karga³

2009

The Endocrinologist

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“…It is well known that hypercalcemia, particularly in polyostotic patients, can be a consequence of immobilization, although not commonly reported [105]. Hypercalcemia is more likely to occur in patients with PDB as a consequence of a hyperparathyroid status [106], but a considerable confusion among primary, secondary and tertiary forms of hyperparathyroidism is still existing.…”

Section: Calcium Metabolism Disturbancesmentioning

confidence: 99%

Pagetʼs disease of bone: thereʼs more than the affected skeletal – a clinical review and suggestions for the clinical practice

Falchetti

Masi²,

Brandi

2010

Current Opinion in Rheumatology

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“…As example, primary and secondary hyperparathyroidism, that may co-exist with the classic PDB for their predominant age of onset [95], definitively affect either bone turnover or PDB clinical expression.…”

Section: European Journal Of Clinical Investigation Vol 40 661mentioning

confidence: 99%

“…Moreover, a chance association of two common diseases such as PDB and primary hyperparathyroidism should be always considered [95].…”

Section: Genetic Counsellingmentioning

confidence: 99%

“…Finally, in the clinical practice it should be always considered that several factors may negatively affect bone turnover, and, consequently, influence the clinical expression of PDB other than genetic polymorphisms. As example, primary and secondary hyperparathyroidism, that may co-exist with the classic PDB for their predominant age of onset [95], definitively affect either bone turnover or PDB clinical expression.…”

Section: European Journal Of Clinical Investigation Vol 40 661mentioning

confidence: 99%

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Genetic aspects of the Paget’s disease of bone: concerns on the introduction of DNA‐based tests in the clinical practice. Advantages and disadvantages of its application

Falchetti

Marini

Masi

et al. 2010

Eur J Clin Investigation

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Background A large amount of genetic studies have clearly demonstrated the existence of a genetic susceptibility to Paget's disease of bone (PDB). Although the disease is genetically heterogeneous, the SQSTM1 ⁄ p62 gene, encoding a protein with a pathophysiological role in both osteoclast differentiation and activity, has been found worldwide to harbour germline mutations in most of the PDB patients from geographically distant populations originating from different areas of Europe, both in sporadic and familial cases.

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What Is the Relationship Between Paget's Disease of Bone and Hyperparathyroidism?

Cited by 14 publications

References 46 publications

Coexistence of Primary Hyperparathyroidism and Paget Disease

Coexistence of Primary Hyperparathyroidism and Paget Disease

Pagetʼs disease of bone: thereʼs more than the affected skeletal – a clinical review and suggestions for the clinical practice

Genetic aspects of the Paget’s disease of bone: concerns on the introduction of DNA‐based tests in the clinical practice. Advantages and disadvantages of its application

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