What is the prevalence of hypertrophic scarring following burns?

Bombaro, Kristine M; Engrav, Loren H.; Carrougher, Gretchen J.; Wiechman, Shelly A; Faucher, Lee D.; Costa, B. A.; Heimbach, David M.; Rivara, Frederick P.; Honari, Shari

doi:10.1016/s0305-4179(03)00067-6

Cited by 291 publications

(146 citation statements)

References 3 publications

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“…Studies performed after 2000 show greater similarity with a 5% variance in prevalence. In these studies the lowest prevalence was 67% in an American study 11 and the highest was 72% in an Italian study 12 .…”

Section: Literature Reviewmentioning

confidence: 86%

An exploration of burn survivors' experiences of Pressure Garment Therapy at a tertiary hospital in South Africa

Pillay

Visagie

Mji

2016

S. Afr. j. occup. ther

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Section: Literature Reviewmentioning

confidence: 86%

An exploration of burn survivors' experiences of Pressure Garment Therapy at a tertiary hospital in South Africa

Pillay

Visagie

Mji

2016

S. Afr. j. occup. ther

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“…Previous research has reported that some herbal extracts have demonstrated beneficial effects on scar treatment (Bombaro et al, 2003;Hosnuter et al, 2007;Lawrence, 1967;Widgerow et al, 2000). Quercetin, a bioflavonoid from Allium cepa, has shown antiproliferative effects on both normal and malignant cells and also exhibited antihistamine release effects.…”

Section: Introductionmentioning

confidence: 99%

“…Quercetin, a bioflavonoid from Allium cepa, has shown antiproliferative effects on both normal and malignant cells and also exhibited antihistamine release effects. These properties could theoretically prove beneficial in reversing the inflammatory and proliferative responses (Bombaro et al, 2003;Widgerow et al, 2000). Willital and Heine (1994) reported using onion extracts to treat fresh scars after thoracic surgery in 45 cases of children and adolescents.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of the combination of herbal extracts and a silicone derivative in the treatment of hypertrophic scar formation after burn injury

Muangman¹,

Aramwit

Palapinyo³

et al. 2011

Afr. J. Pharm. Pharmacol.

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The development of hypertrophic scars is an unsolved problem in the process of wound healing. The objective of this research was to study the efficacy of the combination of herbal extracts and a silicone derivative in a gel preparation (Cybele ® Scagel) on the treatment of deep second degree burns after complete epithelialization. Sixty-three patients were enrolled in this study. One wound area larger than 10 × 10 cm was selected from each patient to receive treatment with Cybele ® Scagel. Patients were observed for pigmentation, pliability, pain and itching for 0, 2, 4, 8, 12, 16, 20 and 24 weeks after treatment. Their data and wound characteristics were collected during each visit using the Vancouver scar scale. After 24 weeks, all scales (pigmentation, pliability, pain and itching) were significantly lower in the sites treated with Cybele ® Scagel compared with the previous time points (p< 0.05). However, vascularity and height scale were not significantly different (p> 0.05). One patient was excluded at week 2 because of moderate itching at the wound site, which could have interfered with the evaluation. The application of Cybele ® Scagel might have some beneficial effects for prevention of hypertrophic scar formation after partial thickness burn injuries.

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“…Hypertrophic scar and contracture are especially problematic in the aftermath of burn injury, afflicting as many as 60% of burn-injured patients, restricting movement and function and having obvious psychological and social costs [12][13][14]. A recent investigation found that colonization of a burn wound by pathogenic bacteria correlates with the development of hypertrophic scarring [11].…”

mentioning

confidence: 99%

Local Probiotic Therapy with Lactobacillus plantarum Mitigates Scar Formation in Rabbits after Burn Injury and Infection

Satish

Gallo

Johnson

et al. 2017

Surgical Infections

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Background: Infection is the most common complication in burn-injured patients and is believed to contribute to the hypertrophic scarring frequently observed in such injury. Pseudomonas aeruginosa is a common pathogen in burn wound infection. We examined the effect of local probiotic therapy with Lactobacillus plantarum on the severity of the scarring following burn wounding and infection with P. aeruginosa in a rabbit model. Methods: Full-thickness burn wounds were inoculated with control vehicle or L. plantarum; wounds were then challenged with bioluminescent P. aeruginosa. The time course of the ensuing infection was monitored by quantification of the emitted light. After allowing wounds to contract to near completion, they were harvested and analyzed for markers of scar formation. Results: Application of L. plantarum curtailed both the severity and the length of the pseudomonal infection. Probiotic therapy significantly reduced both Type I collagen mRNA concentrations and total collagen protein accumulation in infected wounds, consistent with reduced scarring. Surprisingly, the probiotic showed a nearly equivalent effect in uninfected wounds. Masson's trichrome staining confirmed these findings histologically. Conclusions: Lactobacillus plantarum shows exciting potential as a therapeutic agent to both counteract burn wound infection and to alleviate scarring even in the absence of infection.

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What is the prevalence of hypertrophic scarring following burns?

Cited by 291 publications

References 3 publications

An exploration of burn survivors' experiences of Pressure Garment Therapy at a tertiary hospital in South Africa

An exploration of burn survivors' experiences of Pressure Garment Therapy at a tertiary hospital in South Africa

Efficacy of the combination of herbal extracts and a silicone derivative in the treatment of hypertrophic scar formation after burn injury

Local Probiotic Therapy with Lactobacillus plantarum Mitigates Scar Formation in Rabbits after Burn Injury and Infection

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