Efficacy of the combination of herbal extracts and a silicone derivative in the treatment of hypertrophic scar formation after burn injury

Abstract

The development of hypertrophic scars is an unsolved problem in the process of wound healing. The objective of this research was to study the efficacy of the combination of herbal extracts and a silicone derivative in a gel preparation (Cybele ® Scagel) on the treatment of deep second degree burns after complete epithelialization. Sixty-three patients were enrolled in this study. One wound area larger than 10 × 10 cm was selected from each patient to receive treatment with Cybele ® Scagel. Patients were observed for pigmentation, pliability, pain and itching for 0, 2, 4, 8, 12, 16, 20 and 24 weeks after treatment. Their data and wound characteristics were collected during each visit using the Vancouver scar scale. After 24 weeks, all scales (pigmentation, pliability, pain and itching) were significantly lower in the sites treated with Cybele ® Scagel compared with the previous time points (p< 0.05). However, vascularity and height scale were not significantly different (p> 0.05). One patient was excluded at week 2 because of moderate itching at the wound site, which could have interfered with the evaluation. The application of Cybele ® Scagel might have some beneficial effects for prevention of hypertrophic scar formation after partial thickness burn injuries.

Effects of extractum cepae, heparin, allantoin gel and silver sulfadiazine on burn wound healing: an experimental study in a rat model

“…Allantoin is known to have supportive effects on the primary and secondary wound healing process (Hosnuter et al 2007;Koc et al 2008;Karagoz et al 2009;Muangman et al 2011). It was shown that heparin, cepae extract and allantoin mixtures decrease dermal scar formation more effectively than steroids (Beuth et al 2006;Temiz et al 2009).…”

“…Allantoin is also a counterirritant that helps alleviate skin irritation. Allantoin has emollient and soothing properties and can reduce inflammation (Hosnuter et al 2007;Campanati et al 2010;Muangman et al 2011).…”

Prospective randomize-controlled comparison between silicone plus herbal extract gel versus Aloe vera gel for burn scar prophylaxis

“…It may be because A. vera extract is constituted in both gels. The A. vera extract has a natural cyclooxygenase II (COX-2) inhibiting property, which decreases pain and inflammation so it can improve the feeling of pain in both groups [6,12]. Moreover, this study was controlled by using only topical preparation so the efficacy of treatment might not be sufficient for those patients who have deeper wounds and more aggressive scar and it may be necessary to include other combination therapies such as pressure garment and surgical scar correction.…”

“…The early wound closure by epithelialization might decrease the chance of hypertrophic scar formation. It contains salicylate compound, which can decrease pain and itch [12]. Although it has an effect on vascularity, itch and pain parameters, there are other compounds in silicone plus herbal extract gel in study group, which can improve the effect on itch, pain and hypervascular conditions.…”

“…Although it has an effect on vascularity, itch and pain parameters, there are other compounds in silicone plus herbal extract gel in study group, which can improve the effect on itch, pain and hypervascular conditions. These compounds were reported in studies on the prevention of hypertrophic scar formation [10][11][12]. Nano Hydroxyprolisilane CN or silicone gel derivative generates static electricity and can help in the alignment of collagen fibers.…”