What is the impact of electromagnetic waves on epileptic seizures?

Çınar, Nilgün; Sahin, Şevki; Erdinç, Oğuz Osman

doi:10.12659/msmbr.883907

Cited by 5 publications

(6 citation statements)

References 24 publications

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“…The primary search yielded 7766 studies (PubMed, n = 1227; Scopus, n = 6470; Google Scholar, n = 69). Only 33 studies met all the inclusion criteria and were included in the current systematic review 15–47 (Figure 1). Table 1 shows a summary of these studies.…”

Section: Resultsmentioning

confidence: 99%

“…However, the relevance of these small physiological changes remains unclear and mechanistic explanations are still lacking 48 . On the other hand, many animal 19,22,24,26,28,30,34,37,39,42 and human studies 18,27,29,38,43–45 have suggested that exposure to RF‐EMF may be harmful in patients with epilepsy. This harm may show itself either with an increase in seizure frequency 37,38 or with cognitive problems in PWE 43 .…”

Section: Discussionmentioning

confidence: 99%

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Smart devices/mobile phone in patients with epilepsy? A systematic review

et al. 2021

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We systematically reviewed the existing literature on the safety of the use of smartphone, mobile phone/Internet, and Wi‐Fi by people with epilepsy (PWE), according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement. Scopus, MEDLINE, and Google Scholar from the inception to April 9, 2021 were searched. These key words were used “epilepsy” OR “seizure” AND “Mobile Phone” OR “Cell Phone” OR “Smartphone” OR “Wi‐Fi” OR “Electromagnetic” OR “Radiation.” The primary search yielded 7766 studies; 33 studies were related. In total, 19 manuscripts were based on animal/computational studies and 14 articles reported human investigations. Among animal studies, 10 articles suggested detrimental effects by electromagnetic fields (EMFs) on brain function/seizure activity, while nine studies negated this hypothesis. Among human studies, seven studies suggested detrimental effects by EMFs on brain function/seizure activity, while seven studies negated this hypothesis. None of the studies provided a good level of evidence. In one human study, all seven patients with epilepsy and abnormal EEG during the sham exposure, had an increase in the number of epileptic events with exposure to mobile phone radiation. In another study of the detrimental effects of smart technology device overuse among school students, an association was found between reporting seizures and the hours of smart technology device use. While high‐quality evidence on the safety of the use of smartphone, mobile phone/Internet, and Wi‐Fi in PWE is lacking, prudent use of these technologies, including using wired hand‐free sets or other exposure‐reducing measures is recommended.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Smart devices/mobile phone in patients with epilepsy? A systematic review

et al. 2021

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“…In a study done by López-Martín and colleagues [31], they found that 900 MHz GSM radiation triggered a marked increase in neuronal excitability in seizure-prone rats, as manifested by behavioral indicators, EEG indicators, and neuronal c-Fos expression. Cinarand colleagues [32] also investigated the effects of exposure to different frequencies of EMWs in various durations in a mouse epilepsy model induced by pentylenetetrazole (PTZ), and they found that acute exposure to EMW may facilitate epileptic seizures by shortening initial seizure latency, which may be independent of EMW exposure time. Similarly, Persinger and Belanger-Chellew [33] observed an increase in the incidence of seizures in rats when mean-field intensity was raised.…”

Section: Discussionmentioning

confidence: 99%

Effects of mobile phones electromagnetic radiation on patients with epilepsy: an EEG study

Azmy

Shamloul

Elsawy

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

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Background: Recently, an exceptional increase was witnessed in cell phone users. The brain has greater exposure to the electromagnetic field (EMF) created during mobile phone use than the rest of the body, which may impair its function. In persons with epilepsy, the brain has more tendencies towards electrical instability. Objectives: The current study aims at investigating the effect of mobile phone radiation (MPR) on the electroencephalogram (EEG) of persons with epilepsy as well as healthy adults. Subjects and methods: Thirty patients with idiopathic epilepsy and 30 matching controls underwent EEG recording including 15 min of sham exposure followed by 30 min of real exposure to MPR and a final postexposure recording for extra 15 min. The number of abnormal EEG events was counted during sham and real exposure for each subject. Correlation analysis was done between the number of epileptic events detected during the real exposure to MPR and the patients' clinical data Results: In the control group, the EEG under real MPR exposure showed no abnormal discharges. In persons with epilepsy, all those with abnormal EEG during sham exposure MPR (33%) showed an increase in the number of events with real exposure to MPR. One patient showed a change in the pattern of discharge from interictal changes to an ictal rhythm. Another patient with normal EEG during sham record developed temporal epileptiform discharges during real exposure.Conclusion: Mobile phone radiation shows recognizable effects on the brain rhythm of persons with epilepsy. These results should be confirmed by future studies to establish a recommendation addressing the use of such devices in epileptic patients.

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“…PTZ was dissolved in saline solution. A chronometer was used for determining the duration of the beginning and the first seizure after injection [23]. The animals were divided into seven groups using the randomized block design method:…”

Section: Experimental Designmentioning

confidence: 99%

“…The intensity of seizures was scored according to the Racine's scoring system [26]. Score 1 indicated only one tick, score 2, the extension of hands or tail, score 3 frequent limb movement with head extension, score 4 standing on two legs and falling, score 5 frequent standing and falling, and score 6 indicated severe tonic-colonic attacks [23][24][25][26]. The components measured and compared between the groups included threshold (latency), number of convulsions (during one hour), intensity (total scores in each attack during 1.5 hours), the duration of convulsions (sum of durations), and the time to show the convulsion with score 6.…”

Section: Wwwjbpeorgmentioning

confidence: 99%

Effect of Microwave Wi-Fi Radiation at Frequency of 2.4 GHz on Epileptic Behavior of Rats

et al. 2018

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Background: Electromagnetic fields (EMF) with different intensities are widely used at home, offices and public places.Today, there is a growing global concern about the effects of human exposure to EMFs. Epilepsy is one of the most common chronic neurological diseases, affecting 50 million people of all ages worldwide. We aimed to investigate the effect of exposure to Wi-Fi radiation on epileptic behavior of rats.Methods: 147 male rats, weighing 200-250 g, were divided into seven groups; negative control (no intervention), sham 1(distilled water), positive control (Pentylentetrazol [PTZ]), intervention group 1 (PTZ + Wi-Fi “off”), sham 2 (distilled water + Wi-Fi “off”), sham 3 (distilled water + Wi-Fi “on”), and intervention group 2 (PTZ + Wi-Fi “on”). The rats were exposed to Wi-Fi for 2h at a distance of 30cm from a commercial Wi-Fi router. Convulsive behaviors of rats were monitored and scored based on the intensity and type by measuring latency/threshold time, number of convulsions, sum of scores and durations of seizure, and duration of score 6 seizure. Kruskal-Wallis and Mann-Whitney U-tests were used to analyze the data.Results: Convulsion was observed in interventions Group 4 and Group 7, and positive control. The mean number of events, and sum of scores were significantly different in intervention 2 than other two groups. However, the differences in mean threshold, mean sum of durations and “ time to show convulsion with score 6 ” were not statistically significant (P>0.05).Conclusion: Due to limitations of our study including the sample size, these findings should be interpreted with caution. In this study, exposure to 2.4 GHz Wi-Fi radiation showed significant beneficial effects on the epileptic behaviour of rats. More experiments are needed to verify if these exposures can be used as a therapeutic approach for amelioration of seizures in epilepsy.

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What is the impact of electromagnetic waves on epileptic seizures?

Cited by 5 publications

References 24 publications

Smart devices/mobile phone in patients with epilepsy? A systematic review

Smart devices/mobile phone in patients with epilepsy? A systematic review

Effects of mobile phones electromagnetic radiation on patients with epilepsy: an EEG study

Effect of Microwave Wi-Fi Radiation at Frequency of 2.4 GHz on Epileptic Behavior of Rats

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