What is the impact of stromal microinvasion on oncologic outcomes in borderline ovarian tumors? A multicenter case–control study

Boyraz, Gökhan; Salman, Mehmet Çoşkun; Gültekin, Murat; Özkan, Nazlı Topfedaisi; Uçkan, Hasan; Güngördük, Kemal; Gülseren, Varol; Ayik, Hulya; Toptaş, Tayfun; Kuru, Oğuzhan; Sözen, Hamdullah; Erturk, Anil; Özgül, Nejat; Meydanlı, Mehmet Mutlu; Şancı, Muzaffer; Turan, Taner; Güngör, Tayfun; Şimşek, Tayup; Topuz, Samet; Yüce, K.

doi:10.1007/s00404-017-4496-4

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…Also, there is controversy on the relevance of microinvasion to recurrence, which is defined as the presence of infiltration to stroma less than 3 mm in the longest linear dimension or ≤ 10 mm 2 in one or more points (14,23). Boyraz et al demonstrated the relevance of microinvasion to decreasing disease-free survival (13). In our study, none of the histological factors including micropapillary, microinvasion, and noninvasive peritoneal implants significantly affected the recurrence, but it was with a shorter recurrence interval in micropapillary histology (110 months vs. 117 months).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Clinicopathologic Factors and Surgery Management on Borderline Ovarian Tumor Outcomes

et al. 2022

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Background: Borderline ovarian tumor (BOT) is a tumor most prevalent in young woman with desire to fertility. There are some controversies on the patient characteristic besides to the factors affecting the recurrence rate among different races. Objectives: The aim of this study is to evaluate clinicopathologic features of the tumor to discover the controversies on the topic. Methods: Medical data of the all referred patients to Motahari clinic from January 2010 till October 2020 were recorded. Patient clinicopathologic characteristics affecting on outcome were evaluated. By using SPSS software, data were tested by chi-square and fish exact test. Also, log rank test was used for survival analysis Results: Totally 145 patients were enrolled. 61.4% versus 38.6% of the patients underwent fertility sparing surgery and radical surgery respectively with common characteristics of mostly belong to stage 1A disease (61.8% vs. 66.1%), unilateral (93.3% vs. 89.3%), serous histology (51.7% vs. 66.1%). The characteristics were different in the aspects of age and tumor size. In the aspect of recurrence rate, higher FIGO stage, younger age, tumor size less than 10cm, performing laparoscopy and fertility sparing surgery were with higher rate of recurrence (P-value < 0.05) while histology type of the tumor, lateralization, micropapillary, microinvasion, noninvasive peritoneal implants, receiving adjuvant chemotherapy and performing lymphadenectomy were not statistically significant for recurrence (P-value > 0.05). Two patients had malignant transformation. Conclusions: Fertility sparing surgery and higher FIGO stages are with more recurrence rate in Borderline ovarian tumor patients. However, micropapillary, microinvasion were not significantly with higher recurrence rate in our study but they are challenging issues in border line ovarian tumors among different studies. Due to most prevalence of border line ovarian tumors in young women and desire of fertility preservation, we should notice more to clinicopathologic and surgery types affecting on recurrence of BOTs.

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Section: Discussionmentioning

confidence: 99%

“…Some factors influence the recurrence development including advanced maternal age, CA125 level, and invasive implantations (3). It should be mentioned that it is controversial to attribute the prognosis and recurrence rate to the pres-ence of micro-papillary and microinvasion patterns (8)(9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Clinicopathologic Factors and Surgery Management on Borderline Ovarian Tumor Outcomes

et al. 2022

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“…Patients with microinvasive BOT had a significantly higher rate of recurrence than patients without microinvasive BOT (17.4 vs. 7.8%, OR 3.55, 95% CI 1.091–11.59, p = 0.03) . In particular stromal microinvasion was found as a prognostic factor for significantly shorter disease free survival (26.7 vs. 11.9 months, p = 0.031) ( 73 ).…”

Section: Disease Recurrencementioning

confidence: 99%

The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age

et al. 2022

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Borderline ovarian tumors (BOTs) account for approximately 15% of all epithelial ovarian cancers. In 80% of cases the diagnosis of BOTs is done at stage I and more than a third of BOTs occurs in women younger than 40 years of age wishing to preserve their childbearing potential; the issue of conservative surgical management (fertility-sparing treatment) is thus becoming of paramount importance. At early stages, the modalities of conservative treatment could range from mono-lateral cystectomy to bilateral salpingo-oophorectomy. Although cystectomy is the preferred method to promote fertility it can lead to an elevated risk of recurrence; therefore, an appropriate counseling about the risk of relapse is mandatory before opting for this treatment. Nevertheless, relapses are often benign and can be treated by repeated conservative surgery. Besides the stage of the disease, histological subtype is another essential factor when considering the proper procedure: as most mucinous BOTs (mBOTs) are more commonly unilateral, the risk of an invasive recurrence seems to be higher, compared to serous histotype, therefore unilateral salpingo-oophorectomy is recommended. In the appraisal of current literature, this review aims to gain better insight on the current recommendations to identify the right balance between an accurate staging and an optimal fertility outcome.

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Significance of lymph node ratio on survival of women with borderline ovarian tumors

Nusbaum

Mandelbaum

Machida

et al. 2020

Arch Gynecol Obstet

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What is the impact of stromal microinvasion on oncologic outcomes in borderline ovarian tumors? A multicenter case–control study

Cited by 5 publications

References 30 publications

Evaluation of Clinicopathologic Factors and Surgery Management on Borderline Ovarian Tumor Outcomes

Evaluation of Clinicopathologic Factors and Surgery Management on Borderline Ovarian Tumor Outcomes

The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age

Significance of lymph node ratio on survival of women with borderline ovarian tumors

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