Significance of lymph node ratio on survival of women with borderline ovarian tumors

Nusbaum, David J.; Mandelbaum, Rachel S.; Machida, Hiroko; Matsuzaki, Shinya; Roman, Lynda D.; Sood, Anil K.; Gershenson, David M.; Matsuo, Koji

doi:10.1007/s00404-020-05535-0

Cited by 9 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our study exhibit that 51.68% (231/447) ovarian cancers had LNM when diagnosed. As an independent prognostic factor for OS, LNM is demonstrated by many previous researches 20 - 21 and summed in a meta-analysis 22 . As an indicator of poor prognosis, it is also a key factor for patients with OC to select neoadjuvant therapy before surgery 23 - 24 .…”

Section: Discussionmentioning

confidence: 92%

Predictive value of indicator of CA125 combined with D-dimer (ICD) for lymph node metastasis in patients with ovarian cancer: A two center cohort study

Zhang¹,

Guan²,

Yin³

et al. 2022

J. Cancer

View full text Add to dashboard Cite

Background: The clinical serum markers CA125 and D-dimer have been reported to predict lymph node metastasis(LNM) in several malignant tumors, but the reports in ovarian cancer(OC) are still absent. The purpose of this study was to explore the value of indicator CA125 combined with D-dimer (ICD) in predicting LNM in patients with OC. Methods: A total of 447 patients diagnosed with OC from January 2008 to June 2019 were included in this retrospective study as the training set. A total of 284 patients were included in the validation set. The optimal cut-off critical value of ICD was evaluated by the receiver operating characteristic curve (ROC), and the maximum Youden index (sensitivity + specificity-1). Univariate and multivariate analysis were used to evaluate ICD as a predictor of LNM in OC. Results: According to ROC curve, area under curve (AUC) of ICD (AUC=0.706, p<0.001) was significantly larger than that of CA125 (AUC=0.671, p<0.001) and D-dimer (AUC=0.562, p=0.022) alone. Multivariate analysis showed that ICD (HR 2.651, 95% CI 1.273-5.520, p=0.009) was an independent predictor of LNM and overall survival (OS) in OC. It has also been verified in another medical center. Conclusion: ICD is an independent predictor of LNM in ovarian cancers, which is helpful for clinicians to draw up individual treatment plans.

show abstract

Section: Discussionmentioning

confidence: 92%

Predictive value of indicator of CA125 combined with D-dimer (ICD) for lymph node metastasis in patients with ovarian cancer: A two center cohort study

Zhang¹,

Guan²,

Yin³

et al. 2022

J. Cancer

View full text Add to dashboard Cite

show abstract

“…It is known that with lymph node positivity, the stage rises and the prognosis worsens. This has been supported by studies showing that as the rate of positive lymph nodes increases, survival decreases [11,12]. However, in these studies, no information was given on the number of lymph nodes that should be removed to detect lymph node positivity and the number of lymph nodes that should ideally be removed.…”

Section: Discussionmentioning

confidence: 99%

Ideal Lymph Node Number for Ovarian Malignancies

Karadağ¹,

Karakaya²

2022

Cureus

View full text Add to dashboard Cite

Objective: Although there are studies in which the ideal number of lymph nodes for early-stage ovarian cancer is specified, no study has been found on the number of lymph nodes that should ideally be removed by systematic lymph node dissection, including advanced-stage patients. The present study was aimed to retrospectively investigate the number of lymph nodes that need to be removed to detect lymph node positivity and the effect of this number on prognosis.Methodology: A total of 155 patients over the age of 18 who were diagnosed with ovarian cancer without secondary malignancy and who underwent surgical lymph node dissection were included in the study between 2015 and 2020.Results: A total of 155 patients underwent lymphadenectomy and the median number of removed lymph nodes was 24. Lymph node positivity was detected in 72 (46.4%) of these patients, while the median number of positive lymph nodes was 4 in the lymph node-positive group. A statistically significant positive correlation was found between the number of lymph nodes removed and the median overall survival (OS) (r = 0.546, p<0.001). At the same time, when the number of 24 lymph nodes, which is the median number of lymph nodes removed and the value found to detect lymph node positivity in the receiver operating characteristic (ROC) curve, is taken as cut off; mean OS was found to be statistically significantly higher in the group with adequate lymph node dissection compared to the group with insufficient lymph node dissection (46.46±35.22 vs 22.33±21.43; p < 0.001, respectively). Conclusion: it was shown that more than 24 lymph nodes are required for adequate lymph node dissection in the patients included in the study, and thus it can contribute positively to the prognosis. With the support of more comprehensive and prospective studies conducted on this subject to this study, clearer data will emerge about the number of lymph nodes that should be removed in an ideal surgery.

show abstract

“…Серозные и муцинозные пограничные опухоли являются наиболее частым подтипом пограничных эпителиальных новообразований, которые обычно поражают молодых женщин, относительно редки, имеют хороший прогноз из-за отсутствия стромальной инвазии. Вовлечение лимфатических узлов также является относительно распространенным явлением [44]. Пограничные опухоли имеют такие же результаты визуализации, как и их злокачественные аналоги, серозные пограничные опухоли чаще поражают оба яичника по сравнению с муцинозными, которые чаще всего односторонние [13].…”

Section: эпителиальные опухоли яичниковunclassified

“…Пограничные опухоли имеют такие же результаты визуализации, как и их злокачественные аналоги, серозные пограничные опухоли чаще поражают оба яичника по сравнению с муцинозными, которые чаще всего односторонние [13]. ПЭТ/КТ с ФДГ имеет низкую диагностическую ценность при дифференциации доброкачественных и пограничных опухолей, поскольку эти опухоли могут сопровождаться низким поглощением ФДГ или его отсутствием, что дает ложноотрицательные результаты, поэтому они редко диагностируются до операции [44].…”

Section: эпителиальные опухоли яичниковunclassified

The role of PET/CT in oncogynecology (literature review)

Николаева

Тарачкова

Шейх

et al. 2023

Medicinskaâ vizualizaciâ

View full text Add to dashboard Cite

Purpose: to consider the modern possibilities of positron emission tomography combined with computed tomography (PET/CT) with FDG in the diagnosis of oncological formations in gynecology.Materials and methods. Search, selection and evaluation of existing foreign and domestic research included in the peer-reviewed E-library, PubMed, GoogleScholar, Scopus.Results. This article summarizes the existing evidence base to establish the clinical relevance and new possibilities for the use of FDG PET/CT in common gynecological malignancies.Conclusion. The use of FDG PET/CT can have a significant impact on patient management by improving cancer staging, influencing patient choice for treatment, and detecting early disease recurrence.

show abstract

Significance of lymph node ratio on survival of women with borderline ovarian tumors

Cited by 9 publications

References 36 publications

Predictive value of indicator of CA125 combined with D-dimer (ICD) for lymph node metastasis in patients with ovarian cancer: A two center cohort study

Predictive value of indicator of CA125 combined with D-dimer (ICD) for lymph node metastasis in patients with ovarian cancer: A two center cohort study

Ideal Lymph Node Number for Ovarian Malignancies

The role of PET/CT in oncogynecology (literature review)

Contact Info

Product

Resources

About