What is the better formulation of microencapsulated potassium chloride?

Abstract

A single blind cross-over study was performed comparing a new microencapsulated potassium chloride tablet (MET) with two reference formulations of oral potassium, namely potassium chloride solution (PS), and microencapsulated potassium chloride capsules (MEC), in 18 normal healthy volunteers. The potassium chloride induced change in gastric potential difference (PD) of the mucosa was the main criterion of comparison and was assessed by the area above curve (AAC), the total duration of the effect (TDE), the maximal variation of PD (delta MAX), and the aggression index (AI). The results showed that all three formulations induced a fall in PD; the delta MAX and AAC were significantly greater for PS indicating a higher aggressive effect of the solution; MET had significantly less aggressive effect than MEC when assessed by all parameters.

2D Nanostructured Metal Hydroxides with Gene Delivery and Theranostic Functions; A Comprehensive Review

“…Among those 2D inorganic materials, the carbonate phase of LDH known as a natural mineral, hydrotalcite, has attracted a great attention in nanomedicine, since it was already commercialized by European biopharmaceutical company, Bayer, as antacid and anti‐pepsin agent, with the product name of “Talcid®” . It contains the basic magnesium aluminium hydroxide carbonate [Mg 6 Al 2 (CO 3 )(OH) 16 ⋅ 4H 2 O; Talcid® (500 mg per tablet)], whose capacity to neutralize gastric acid corresponds to 13 mEq H + .…”

“…It contains the basic magnesium aluminium hydroxide carbonate [Mg 6 Al 2 (CO 3 )(OH) 16 ⋅ 4H 2 O; Talcid® (500 mg per tablet)], whose capacity to neutralize gastric acid corresponds to 13 mEq H + . It is, therefore, prescribed to the patients with gastric or duodenal ulcers and for acute or chronic gastritis . Later on, synthetic LDHs were further developed for delivery carriers due to their biocompatibility, controllable drug/gene loading capacity and enhanced cellular permeability .…”

“…Many researchers have been developing various gene‐LDH nanohybrid systems in in‐vitro (Table ) ,,,,,,. Recently, Zheng et al .…”

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

“…LDHs are usually chemically inert, which ensures their excellent biocompatibility and further biomedical applications . For example, a type of LDH, “Talcid”, with the composition of Mg 6 Al 2 (CO 3 )(OH) 16 ⋅ 4 H 2 O, has been commercialized for more than 20 years as an anti‐pepsin and gastric‐acid‐neutralizing agent …”

Electrospun organic–inorganic nanohybrids as sustained release drug delivery systems

“…Electrostatic interactions and hydrogen bonds between the layers and the contents of the interlayer space hold adjacent layers together, forming a three-dimensional structure. 23,24 The earliest application of LDHs in relation to human health was their use as antacids and antipeptic reagents in 1996, 25 and in the last decade nanometer-sized LDH materials (50-300 nm) have been increasingly explored as drug and gene carriers and delivery systems. 26 Many drugs (e.g.…”