What Is New in Neuromodulation?

Moore, Courtenay; Rueb, Jessica; Derisavifard, Samir

doi:10.1007/s11934-019-0920-6

Cited by 15 publications

(12 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In recent years, many new clinical applications have emerged for bioelectronics and neuromodulation (electrical modulation of neural properties) to regulate organ function (Birmingham et al 2014;Horn et al 2019;Moore et al 2019;Payne et al 2019). As the published reviews demonstrate, the vagus nerve has become a key neuromodulation target, with efficacy demonstrated on a range of thoracic and abdominal conditions, in addition to a growing number of CNS sites.…”

Section: Introductionmentioning

confidence: 99%

“…Whereas the vagus regulates abdominal and thoracic organs, the pelvic organs are instead primarily innervated by more caudal neural circuits that have also become a focus of neuromodulation (Gaunt and Prochazka, 2006;Liberman et al 2017;Abello and Das, 2018;Kessler et al 2019;Moore et al 2019). Specifically, the 'sacral' component of the parasympathetic system, working together with sacral afferent pathways, is critical for micturition, defecation and sexual function; furthermore, sacral afferents also function in inflammatory and pain conditions originating in the pelvic organs (Gonzalez et al 2014;de Groat and Yoshimura, 2015;Grundy et al 2019).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Functional segregation within the pelvic nerve of male rats: a meso‐ and microscopic analysis

et al. 2020

View full text Add to dashboard Cite

The pelvic splanchnic nerves are essential for pelvic organ function and have been proposed as targets for neuromodulation. We have focused on the rodent homologue of these nerves, the pelvic nerves. Our goal was to define within the pelvic nerve the projections of organ‐specific sensory axons labelled by microinjection of neural tracer (cholera toxin, subunit B) into the bladder, urethra or rectum. We also examined the location of peptidergic sensory axons within the pelvic nerves to determine whether they aggregated separately from sacral preganglionic and paravertebral sympathetic postganglionic axons travelling in the same nerve. To address these aims, microscopy was performed on the major pelvic ganglion (MPG) with attached pelvic nerves, microdissected from young adult male Sprague–Dawley rats (6–8 weeks old) and processed as whole mounts for fluorescence immunohistochemistry. The pelvic nerves were typically composed of five discrete fascicles. Each fascicle contained peptidergic sensory, cholinergic preganglionic and noradrenergic postganglionic axons. Sensory axons innervating the lower urinary tract (LUT) consistently projected in specific fascicles within the pelvic nerves, whereas sensory axons innervating the rectum projected in a complementary group of fascicles. These discrete aggregations of organ‐specific sensory projections could be followed along the full length of the pelvic nerves. From the junction of the pelvic nerve with the MPG, sensory axons immunoreactive for calcitonin gene‐related peptide (CGRP) showed several distinct patterns of projection: some projected directly to the cavernous nerve, others projected directly across the surface of the MPG to the accessory nerves and a third class entered the MPG, encircling specific cholinergic neurons projecting to the LUT. A subpopulation of preganglionic inputs to noradrenergic MPG neurons also showed CGRP immunoreactivity. Together, these studies reveal new molecular and structural features of the pelvic nerves and suggest functional targets of sensory nerves in the MPG. These anatomical data will facilitate the design of experimental bioengineering strategies to specifically modulate each axon class.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional segregation within the pelvic nerve of male rats: a meso‐ and microscopic analysis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Spinal cord injury: Sievert et al published a case series of 4 patients subjected to SNM therapy shortly after a complete spinal cord injury who evolved to having no incontinence or detrusor overactivity (63).…”

Section: Possible Future Indicationsmentioning

confidence: 99%

Sacral neuromodulation - when and for who

Mass-Lindenbaum

Calderón-Pollak

Goldman³

et al. 2021

Int. braz j urol.

View full text Add to dashboard Cite

“…Thirty years into its first reintroduction, it is still surprising how limited the indications for SNM in particular remain in the face of accumulating evidence, albeit from small trials restricted by a small pool of patients and candidates. Off-label use of SNM in chronic pelvic pain syndromes, pregnant women, children and neurogenic bladder patients should be the priority of authoritarian bodies to promote research and insight especially when treatment of such conditions could have remarkable effects on the quality of life of those affected [124].…”

Section: Expanding Indications and Revisiting Limited Applicationsmentioning

confidence: 99%

Neuromodulation in Urology: Current Trends and Future Applications

Yaiesh¹,

Al‐Terki²,

Al-Shaiji³

2020

Neurostimulation and Neuromodulation in Contemporary Therapeutic Practice

View full text Add to dashboard Cite

Urological applications of neuromodulation and neurostimulation are among the most evolving fields for these technologies. First approved for management of refractory urge incontinence, different modalities of neuromodulation and stimulation have been tested, applied and verified for a vast spectrum of voiding and pelvic floor dysfunction disorders. The modalities of delivering this treatment have also evolved in the last three decades, with a focus on sacral neuromodulation. The experimental and established "off-label" applications of neuromodulation have also encompassed chronic pelvic pain disorders, including chronic prostatitis and bladder pain syndrome, among others. In this chapter, we discuss all the hypothesized theories suggested on how this technology provides therapeutic potential for a number of chronic and debilitating urological conditions, the modes of delivery be it anterior, sacral, and posterior tibial to name a few, and the evolving and future applications.

show abstract

What Is New in Neuromodulation?

Cited by 15 publications

References 50 publications

Functional segregation within the pelvic nerve of male rats: a meso‐ and microscopic analysis

Functional segregation within the pelvic nerve of male rats: a meso‐ and microscopic analysis

Sacral neuromodulation - when and for who

Neuromodulation in Urology: Current Trends and Future Applications

Contact Info

Product

Resources

About