What is most relevant in preoperative rectal cancer chemoradiotherapy – the chemotherapy, the radiation dose or the timing to surgery?

Glimelius, Bengt

doi:10.1080/0284186x.2016.1254817

Cited by 9 publications

(4 citation statements)

References 58 publications

(69 reference statements)

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“…However most of the overall survival (OS) prognosis factors were identified with post-operative radiotherapy programs and before TME was systematically performed. This is a major limitation for prognosis factors analysis since publications suggested that the RC modern outcome was much better than it used to be, when trials assessing the benefits of adjuvant therapy were recruiting 7 . The development of staging, surgery, radiotherapy, pathological examination and multidisciplinary teams might have significantly improved the outcome of non-metastatic RC patients.…”

Section: Introductionmentioning

confidence: 99%

Outcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey

Langrand-Escure

Diao

Garcia³

et al. 2018

Sci Rep

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This retrospective study was undertaken to provide more modern data of real-life management of non-metastatic rectal cancer, to compare therapeutic strategies, and to identify prognostic factors of overall survival (OS) in a large cohort of patients. Data on efficacy and on acute/late toxicity were retrospectively collected. Patients were diagnosed a non-metastatic rectal cancer between 2004 and 2015, and were treated at least with radiotherapy. OS was correlated with patient, tumor and treatment characteristics with univariate and multivariate analyses. Data of 593 consecutive non-metastatic rectal cancer patients were analyzed. Median follow-up was 41 months. Median OS was 9 years. Radiotherapy was delivered in pre-operative (n = 477, 80.5%), post-operative (n = 75, 12.6%) or exclusive (n = 41, 6.9%) setting. In the whole set of patients, age, nutritional condition, tumor stage, tumor differentiation, and surgery independently influenced OS. For patients experiencing surgery, OS was influenced by age, tumor differentiation and nodal status. Surgical resection is the cornerstone treatment for locally-advanced rectal cancer. Poor tumor differentiation and node involvement were identified as major predictive factor of poor OS. The research in treatment intensification and in identification of radioresistance biomarkers should therefore probably be focused on this particular subset of patients.

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Section: Introductionmentioning

confidence: 99%

Outcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey

Langrand-Escure

Diao

Garcia³

et al. 2018

Sci Rep

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show abstract

“…However, when organ preservation is not a real option, delayed surgery might not be safe because it may decrease survival due to delay in starting of the adjuvant therapy [13,14].…”

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confidence: 99%

The feasibility of short-course radiotherapy in a watch-and-wait policy for rectal cancer

et al. 2017

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“…During the years, I have also written editorials within my own field of interest, gastrointestinal oncology, most recently [29][30][31][32]. I hope it has not been easier for me to see strengths in manuscripts dealing with gastrointestinal oncology than in other areas of oncology; nor the opposite, i.e., seeing faults in such articles.…”

Section: Improvements For Acta Oncologica During the Past 25 Yearsmentioning

confidence: 99%

Forty-five years in oncology, 25 years with Acta Oncologica

Glimelius

2018

Acta Oncologica

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What is most relevant in preoperative rectal cancer chemoradiotherapy – the chemotherapy, the radiation dose or the timing to surgery?

Cited by 9 publications

References 58 publications

Outcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey

Outcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey

The feasibility of short-course radiotherapy in a watch-and-wait policy for rectal cancer

Forty-five years in oncology, 25 years with Acta Oncologica

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