The feasibility of short-course radiotherapy in a watch-and-wait policy for rectal cancer

Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study

“…The registry has collected data of more than 1000 patients, approximately 50% from published cohort studies, and 50% of unpublished data. 7,8,10,11,[17][18][19] In the registry, 25•3% of patients in a W&W approach developed a local regrowth in the first two years of follow-up. This local regrowth rate is considerably higher than the pooled 2-year local regrowth rate of 15•7% reported in the meta-analyis of Dossa et al This is probably explained by the strict inclusion criteria in the studies of the meta-analysis, whereas the registry is more based on an ' all-comers' strategy without narrow selection criteria.…”

Health-related quality of life in rectal cancer patients undergoing neoadjuvant chemoradiation with delayed surgery versus short-course radiotherapy with immediate surgery: a propensity score-matched cohort study

“…Besides the use of CRT to become eligible for organ preservation in intermediate risk rectal cancer patients, SCRT with delayed surgery has been proposed as alternative to SCRT-IS and was investigated by the Stockholm III trial [14] and by a prospective non-randomized study in elderly patients [34]. The Stockholm III trial showed comparable oncological outcomes between SCRT with delayed surgery and SCRT-IS [14].…”

“…Despite more radiation-induced toxicity after SCRT with delayed surgery, significantly less postoperative complications were observed in this group compared with SCRT-IS. Nonetheless, concerns about delaying surgery after SCRT may include the risk of tumor repopulation [34,35]. Furthermore, the effect of SCRT with delayed surgery on QOL remains yet unknown.…”

Tumour regression after radiotherapy for rectal cancer – Results from the randomised Stockholm III trial

“…No difference in R0 resection, DM, postoperative or late complications could be found but there was an improved OS in patients receiving consolidative chemotherapy. 220…”