2011
DOI: 10.2478/v10011-011-0029-z
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What is a Biomarker? From its Discovery to Clinical Application

Abstract: What is a Biomarker? From its Discovery to Clinical ApplicationThe term biomarker in medicine most often stands for a protein measured in the circulation (blood) whose concentration indicates a normal or a pathological response of the organism, as well as a pharmacological response to the applied therapy. From a wider perspective, a biomarker is any indicator that is used as an index of the intensity of a disease or other physiological state in the organism. This means that biomarkers have a very important rol… Show more

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Cited by 23 publications
(17 citation statements)
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“…The significant increase in ApoB and an unchanged TC and LDL-c are responsible for increased small LDL particles which are very unstable for oxidation (24,25). At the same time, the obtained data with apoB underline again the advantage of the apolipoprotein peptide as a better discriminator for earlier detection of the cardiovascular risk (26,27). The lipid changes in MS(+) patients in creased the risk for coronary events and our obtained data confirm ox-LDL and apoB as key laboratory indicators for the prevention and treatment of cardio vascular diseases in patients with the metabolic syndrome.…”
Section: Discussionmentioning
confidence: 59%
“…The significant increase in ApoB and an unchanged TC and LDL-c are responsible for increased small LDL particles which are very unstable for oxidation (24,25). At the same time, the obtained data with apoB underline again the advantage of the apolipoprotein peptide as a better discriminator for earlier detection of the cardiovascular risk (26,27). The lipid changes in MS(+) patients in creased the risk for coronary events and our obtained data confirm ox-LDL and apoB as key laboratory indicators for the prevention and treatment of cardio vascular diseases in patients with the metabolic syndrome.…”
Section: Discussionmentioning
confidence: 59%
“…In fact, 65% of cTn elevations in patients with negative coronary angiograms represent a true positive for heart disease, although most of these patients do not have AMI (75)(76)(77)(78). Recent guidelines also consider those cTn elevations not to be FP (58).…”
Section: Discussionmentioning
confidence: 99%
“…Yet, many of these deaths can be avoided by early detection, treatment and cure [2]. Tumor markers can express cancer occurrence and growth [3].…”
Section: Simultaneous Detection Of Multiple Tumor Markersmentioning
confidence: 99%